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BMC Pediatrics
Published in: BMC Pediatrics 1/2023

Open Access 01-12-2023 | Vitamin D Deficiency | Research

Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

Authors: Alireza Jashni Motlagh, Ahmadreza Davoodvandi, Sara Esmaelzadeh Saeieh

Published in: BMC Pediatrics | Issue 1/2023

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Abstract

Background

Vitamin D deficiency and insufficiency is common in mothers and infants. The present study was conducted with the aim of association between the level of vitamin D in the mother’s serum and the level of vitamin D in the serum of preterm infants.

Method

The present descriptive – analytical study was performed on 140 mothers and preterm infants referred to the Kamali hospital in Alborz University of Medical Sciences. Sampling was done from available mothers after hospitalization for delivery and their infants during the first 72 hours after delivery. Information from mothers and infants were collected with researcher made check list, including age, type of delivery, number of pregnancies, vitamin D during this pregnancy, infants birth age, gender, and birth weight. Data analysis was performed using SPSS version 24 software.

Results

The average age of mothers was 28 ± 5 years and the average age of infants at the time of birth was 30 ± 1 weeks. Forty two infants (67%) were boys and 23 infants (33%) were girls. The results showed a high rate of vitamin D insufficiency and deficiency in mother (44, 49%) and preterm infants (49, 38%). The results of the Pearson correlation test showed that there is a strong and significant relationship between the serum vitamin D level of mothers and preterm infants (P = 0.001). Logistic regression tests showed that mother’s vitamin D level had an effect on the infant’s vitamin D level.

Conclusion

Considering high rate of vitamin D deficiency and insufficiency and relationship between vitamin D in preterm infants serum and mothers, diagnostic screenings are recommended to investigate vitamin D disorders in pregnant mothers, which should be planned, implemented and followed up in the form of a therapeutic program to prevent the occurrence of complications caused by this disorder in the mother and infant.
Literature
1.
2.
3.
Eremkina AK, Mokrysheva NG, Pigarova EA, Mirnaya SS. Vitamin D: effects on pregnancy, maternal, fetal and postnatal outcomes. Ter Arkh. 2018;90(10):115–27.PubMed
4.
Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess (Winchester, England). 2014;18(45):1–90.
5.
6.
Vinkhuyzen AA, Eyles DW, Burne TH, Blanken LM, Kruithof CJ, Verhulst F, et al. Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the generation R study. J Steroid Biochem Mol Biol. 2016;164:161–7.CrossRefPubMed
7.
Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. Br Med Bull. 2018;126(1):57–77.CrossRefPubMed
8.
9.
Lee AC, Blencowe H, Lawn JE. Small babies, big numbers: global estimates of preterm birth. Lancet Glob Health. 2019;7(1):e2–3.CrossRefPubMed
10.
Harrison MS, Goldenberg RL. Global burden of prematurity. Semin Fetal Neonatal Med. 2016;21(2):74–9 WB Saunders.CrossRefPubMed
11.
Merialdi M, Kozuki N, Katz J, Lee A, Vogel JP, Silveira MF, et al. Maternal stature increases risk of small-forgestational-age and preterm births in low-and middle-income countries: individual participant data meta-analysis and population attributable fraction. J Nutr. 2015;145(11):2542–50.CrossRefPubMed
12.
Jamal S, Srivastava R. A retrospective analytical study of the epidemiology and causes of preterm birth. Int J Reprod Contracept Obstet Gynecol. 2017;6(12):5453–7.CrossRef
13.
Fallahi M, Afjeh A, Saneifard H, Namazi N, Kazemian M, Tabatabaee S. Comparison of vitamin D level in preterm and term infant–mother pairs: a brief study. Iran J Neonatol. 2016;7(1):32–6.
14.
Ni M, Zhang Q, Zhao J, Shen Q, Yao D, Wang T, et al. Relationship between maternal vitamin D status in the first trimester of pregnancy and maternal and neonatal outcomes: a retrospective single center study. BMC Pediatr. 2021;21(1):1–4.CrossRef
15.
Gatera VA, Abdulah R, Musfiroh I, Judistiani RT, Setiabudiawan B. Updates on the status of vitamin D as a risk factor for respiratory distress syndrome. Adv Pharmacol Sci. 2018;2018:8494816.PubMedPubMedCentral
16.
Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med. 2011;183(10):1336–43.CrossRefPubMed
17.
Shahraki AD, Hasanabadi MS, Dehkordi AF. Association of 25-hydroxy vitamin D level in mothers with term and preterm delivery and their neonates. J Res Med Sci. 2020;25:21.PubMedPubMedCentral
18.
Panda M, McIntosh J, Chaudhari T, Kent AL. Do maternal vitamin D levels influence vitamin D levels in preterm neonates? Int J Pediatr. 2019;2019:8613414.CrossRefPubMedPubMedCentral
19.
Hajizadeh S, Shary JR, Reed SG, Wagner CL. The prevalence of hypovitaminosis D and its risk factors in pregnant women and their newborns in the Middle East: a systematic review. Int J Reprod Biomed. 2019;17(10):685.PubMedPubMedCentral
20.
Skouroliakou M, Ntountaniotis D, Massara P, Koutri K. Investigation of multiple factors which may contribute to vitamin D levels of bedridden pregnant women and their preterm neonates. J Matern Fetal Neonatal Med. 2016;29(16):2596–601.PubMed
21.
Mafinezhad S, Sharifian E, Bayani G, Bozorgnia Y, Ahmadabad HN, Kalateh A. Serum level of vitamin D in women with idiopathic preterm labor and women with term labor referred to Bentolhoda hospital in Bojnourd, 2020. Iran J Obstet Gynecol Infertil. 2022;24(13):1–8 [Persian].
22.
Park SH, Lee GM, Moon JE, Kim HM. Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features. Korean J Pediatr. 2015;58(11):427.CrossRefPubMedPubMedCentral
23.
Kassai MS, Cafeo FR, Affonso-Kaufman FA, Suano-Souza FI, Sarni RO. Vitamin D plasma concentrations in pregnant women and their preterm newborns. BMC Pregnancy Childbirth. 2018;18(1):1–8.CrossRef
24.
Saraf R, Morton SM, Camargo CA Jr, Grant CC. Global summary of maternal and newborn vitamin D status–a systematic review. Matern Child Nutr. 2016;12(4):647–68.CrossRefPubMed
25.
Dawodu A, Wagner CL. Prevention of vitamin D deficiency in mothers and infants worldwide—a paradigm shift. Paediatr Int Child Health. 2012;32(1):3–13.CrossRefPubMedPubMedCentral
26.
Nakhaee Moghadam M, Soleimani G, Shafighi Shahri E, Akbarirad F. Evaluation of vitamin D status and effective maternal factors on vitamin D levels in cord blood of infants born in Zahedan. Iran Int J Pediatr. 2021;9(5):13455–62.
27.
Christina KH, Ertl R, Samaha R, Akolekar R, Nicolaides KH. Normal range of maternal serum vitamin D at 11–13 weeks’ gestation. Fetal Diagn Ther. 2011;30(2):94–9.CrossRef
28.
Wang H, Xiao Y, Zhang L, Gao Q. Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring. J Steroid Biochem Mol Biol. 2018;175:146–50.CrossRefPubMed
29.
Roth DE, Morris SK, Zlotkin S, Gernand AD, Ahmed T, Shanta SS, et al. Vitamin D supplementation in pregnancy and lactation and infant growth. N Engl J Med. 2018;379(6):535–46.CrossRefPubMedPubMedCentral
30.
Kiely M, O’Donovan SM, Kenny LC, Hourihane JO, Irvine AD, Murray DM. Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland. J Steroid Biochem Mol Biol. 2017;167:162–8.CrossRefPubMed
31.
Rodda CP, Benson JE, Vincent AJ, Whitehead CL, Polykov A, Vollenhoven B. Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial. Clin Endocrinol. 2015;83(3):363–8.CrossRef
32.
Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics. 2014;133(1):e143–53.CrossRefPubMed
33.
Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26(10):2341–57.CrossRefPubMed
34.
Hollis BW, Wagner CL. Vitamin D and pregnancy: skeletal effects, non-skeletal effects, and birth outcomes. Calcif Tissue Int. 2013;92(2):128–39.CrossRefPubMed
35.
Hollis BW, Wagner CL. Substantial vitamin D supplementation is required during the prenatal period to improve birth outcomes. Nutrients. 2022;14(4):899.CrossRefPubMedPubMedCentral
Metadata
Title
Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants
Authors
Alireza Jashni Motlagh
Ahmadreza Davoodvandi
Sara Esmaelzadeh Saeieh
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2023
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-023-03854-0

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