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BMC Pediatrics
Published in: BMC Pediatrics 1/2021

Open Access 01-12-2021 | Lymphoma | Case report

Primary breast lymphoma of childhood: a case report and review of literature

Authors: Giulia A. Restivo, Marta Pillon, Lara Mussolin, Clara Mosa, Angela Guarina, Angela Trizzino, Salvatore Ialuna, Elisa Carraro, Emanuele S.G. D’Amore, Giovanna Russo, Caterina Elia, Maurizio Mascarin, Adriana Zangara, Paolo D’Angelo, Piero Farruggia

Published in: BMC Pediatrics | Issue 1/2021

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Abstract

Background

Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes.

Case presentation

We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy.

Conclusions

Our case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.
Literature
1.
Murphy JJ, Morzaria S, Gow KW, Magee JF. Breast cancer in a 6-year-old child. J Pediatr Surg. 2000;35(5):765–7.CrossRef
2.
Mance M, Smuđ-Orehovec S, Vrbanović-Mijatović V, Mijatović D Primary alveolar rhabdomyosarcoma of the breast in a 17-year-old girl. J Oncol Pract. 2020;16(2):93–5.CrossRef
3.
Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer. 1972;29:1705–12.CrossRef
4.
Cheah CY, Campbell BA, Seymour JF. Primary breast lymphoma. Cancer Treat Rev. 2014;40(8):900–8.CrossRef
5.
Murphy SB. Classification, staging and end results of treatment of childhood non-Hodgkin lymphomas: dissimilarities from lymphomas in adults. Semin Oncol. 1980;7:332–9.PubMed
6.
Rosolen A, Perkins SL, Pinkerton CR, Guillerman RP, Sandlund JT, Patte C, Reiter A, Cairo MS. Revised international pediatric non-Hodgkin lymphoma staging system. J Clin Oncol. 2015;33:2112–8.CrossRef
7.
Pillon M, Mussolin L, Carraro E, Conter V, Aricò M, Vinti L, Garaventa A, Piglione M, Buffardi S, Sala A, Santoro N, Lo Nigro L, Mura R, Tondo A, Casale F, Farruggia P, Pierani P, Cesaro S, D’Amore ES, Basso G. Detection of prognostic factors in children and adolescents with Burkitt and diffuse large B-cell lymphoma treated with the AIEOP LNH-97 protocol. Brit J Haematol. 2016;175:467–75.CrossRef
8.
Thompson PA, Prince HM. Breast implant-associated anaplastic large cell lymphoma: a systematic review of the literature and mini-meta analysis. Curr Hematol Malignancy Rep. 2013;8(3):196–210.CrossRef
9.
Dixon JM, Lumsden AB, Krajewski A, Elton RA, Anderson TJ. Primary lymphoma of the breast. Br J Surg. 1987;74(3):214–6.
10.
Boothroyd A, Carty H. Breast masses in childhood and adolescence. A presentation of 17 cases and a review of the literature. Pediatr Radiol. 1994;24(2):81–4.CrossRef
11.
Rogers DA, Lobe TE, Rao BN, Fleming ID, Kurt PS, Pratt CB, Pappo AS. Breast malignancy in children. J Pediatr Surg. 1994;29:48–51.
12.
Aguilera NS, Tavassoli FA, Chu WS, Abbondanzo SL. T-cell lymphoma presenting in the breast: a histologic, immunophenotypic and molecular genetic study of four cases. Modern Pathol. 2000;13(6):599–605.CrossRef
13.
Barişta I, Baltali E, Tekuzman G, Kars A, Ruacan S, Ozisik Y, Guler N, Gullu IH, Atahan IL, Firat D. Primary breast lymphomas - a retrospective analysis of twelve cases. Acta Oncol. 2000;39(2):135–9.CrossRef
14.
Abdullah N, Behranwala KA, Wotherspoon A, Gui GP. Adolescent breast lymphoma - apparently aggressive presentation with favourable outcome. J Postgrad Med. 2004;50(3):236–7.PubMed
15.
Lingohr P, Eidt S, Rheinwalt KP. A 12-year-old girl presenting with bilateral gigantic Burkitt’s lymphoma of the breast. Arch Gynecol Obstet. 2009;279(5):743–6.CrossRef
16.
Daneshbod Y, Oryan A, Khojasteh HN, Rasekhi A, Ahmadi N, Mohammadianpanah M. Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature. J Pediatr Hematol Oncol. 2010;32(2):75–8.CrossRef
17.
Ishizuka Y, Horimoto Y, Fujimura J, Ogata K, Murakami F, Onagi H. Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report. Surg Case Rep. 2020;6:87.CrossRef
18.
Charfi L, Houcine Y, Yahyaoui Y, Sahraoui G, Chraiet N, Mrad K, Doghri R. Primary breast Anaplasic Lymphoma Kinase-positive anaplastic lymphoma in an adolescent. Breast J. 2020;26(10):2068–9.CrossRef
19.
Oral H, Turkyilmaz Z, Arslan Kahraman Dİ, Kaya C, Karabulut R, Tartık A, Sönmez K. B-cell lymphoblastic lymphoma of unilateral primary breast mass in a boy aged 11 years. Breast J. 2021;27(3):271–2.CrossRef
20.
el-Ghazawy IM, Singletary SE. Surgical management of primary lymphoma of the breast. Ann Surg. 1991;214(6):724–6.
21.
Hosein PJ, Maragulia JC, Salzberg MP, Press OW, Habermann TM, Vose JM, Bast M, Advani RH, Tibshirani R, Evens AM, Islam N, Leonard JP, Martin P, Zelenetz AD, Lossos IS. A multicentre study of primary breast diffuse large B-cell lymphoma in the rituximab era. Br J Haematol. 2014;165:358–63.CrossRef
22.
Hu S, Song Y, Sun X, Su L, Zhang W. Primary breast diffuse large B-cell lymphoma in the rituximab era: Therapeutic strategies and patterns of failure. Cancer Sci. 2018;109:3943–52.CrossRef
23.
Jennings WC, Baker RS, Murray SS, Howard CA, Parker DE, Peabody LF, Vice HM, Sheehan WW, Broughan TA. Primary breast lymphoma: the role of mastectomy and the importance of lymph node status. Ann Surg. 2007;245(5):784–9.
24.
Ryan G, Martinelli G, Kuper-Hommel M, Tsang R, Pruneri G, Yuen K, Roos D, Lennard A, Devizzi L, Crabb S, Hossfeld D, Pratt G, Dell’Olio M, Choo SP, Bociek RG, Radford J, Lade S, Gianni AM, Zucca E, Cavalli F, Seymour JF, International Extranodal Lymphoma Study Group. Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. Ann Oncol. 2008;19(2):233–41.CrossRef
25.
Wong WW, Schild SE, Halyard M, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: The Mayo Clinic Experience. J Surg Oncol. 2002;80(1):19-25; discussion 26.
26.
Gao Y, Saksena MA, Brachtel EF, Deborah C, Rafferty EA. How to approach breast lesions in children and adolescents. Eur J Radiol. 2015;84(7):1350–64.CrossRef
27.
Raj SD, Shurafa M, Shah Z, Raj KM, Fishman MDC, Dialani VM. Primary and secondary breast lymphoma: clinical, pathologic and multimodality imaging review. Radiographics. 2019;39(3):610–25.CrossRef
28.
Dong A, Wang Y, Lu J, Zuo C. Spectrum of the breast lesions with increased 18F-FDG uptake on PET/CT. Clin Nuclear Med. 2016;41(7):543–57.CrossRef
29.
Minard-Colin V, Auperin A, Pillon M, Burke A, Anderson JR, Barkauskas DA, Wheatley K, Delgado R, Alexander S, Uyttebroeck A, Bollard C, Zsiros J, Csoka M, Goma G, Tulard A, Patte C, Gross TG. Results of the randomized Intergroup trial Inter-B-NHL Ritux 2010 for children and adolescents with high-risk B-cell non-Hodgkin lymphoma (B-NHL) and mature acute leukemia (B-AL): Evaluation of rituximab (R) efficacy in addition to standard LMB chemotherapy (CT) regimen. J Clin Oncol. 2016;34(15_suppl):10507–10507.CrossRef
30.
Mussolin L, Lovisa F, Gallingani I, Cavallaro E, Carraro E, Damanti CC, Vinti L, Sala A, Micalizzi C, Santoro N, Piglione M, Cellini M, Buffardi S, Buldini B, D’Amore E, Biffi A, Pillon M. Minimal residual disease analysis in childhood mature B-cell leukaemia/lymphoma treated with AIEOP LNH-97 protocol with/without anti-CD20 administration. Br J Haematol. 2020,189(3):e108–e111.CrossRef
31.
Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 2013;24(9):2236–44.CrossRef
Metadata
Title
Primary breast lymphoma of childhood: a case report and review of literature
Authors
Giulia A. Restivo
Marta Pillon
Lara Mussolin
Clara Mosa
Angela Guarina
Angela Trizzino
Salvatore Ialuna
Elisa Carraro
Emanuele S.G. D’Amore
Giovanna Russo
Caterina Elia
Maurizio Mascarin
Adriana Zangara
Paolo D’Angelo
Piero Farruggia
Publication date
01-12-2021

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