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Published in: BMC Pediatrics 1/2021

Open Access 01-12-2021 | Diarrhea | Research article

Priorities for intervention to prevent diarrhea among children aged 0–23 months in northeastern Ethiopia: a matched case-control study

Authors: Alemwork Baye, Metadel Adane, Tadesse Sisay, Habtamu Shimels Hailemeskel

Published in: BMC Pediatrics | Issue 1/2021

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Abstract

Background

The global public health problem of diarrhea is most prevalent in developing countries including Ethiopia, especially among children under two years of age. Limited information on the determinants of diarrhea among children aged 0–23 months hinders the design and prioritization of intervention strategies to address childhood diarrhea in Dessie City, northeastern Ethiopia. Therefore, this study was designed to assess the determinants of diarrhea in order to identify priority interventions for its control.

Methods

A community-based matched case-control study was conducted among children aged 0–23 months during January–February 2018. Cases defined as children with acute diarrhea, and controls defined as children without acute diarrhea, were matched by child’s age (months) and place of residence (residing in the same kebele, the lowest local administrative unit, each of which has a population of approximately 5000) during the two weeks prior to data collection. Data were collected from mothers/caregivers of the 119 cases and 238 matched controls using a pre-tested structured questionnaire and an observational checklist. Data were analyzed using conditional logistic regression model with 95% confidence interval (CI); variables with p < 0.05 from multivariable analysis were considered as significantly associated with acute diarrhea among children aged 0–23 months.

Results

Age of mothers/caregivers (> 35 years of age) (adjusted matched odds ratio [adjusted mOR] = 2.00; 95% CI: 1.37–5.8); divorced/widowed marital status (adjusted mOR = 1.40; 95% CI: 1.26–3.3); lack of exclusive breastfeeding (adjusted mOR = 2.12; 95% CI: 1.15–3.70); presence of feces within/around latrines (adjusted mOR = 1.37; 95% CI: 1.21–3.50); lack of handwashing facility near latrine (adjusted mOR = 1.50; 95% CI: 1.30–5.30); presence of domestic sewage discharge within and/or outside the compound (adjusted mOR = 3.29; 95% CI: 1.85–7.50) and practice of handwashing at fewer than three of the five critical daily times (adjusted mOR = 4.50; 95% CI: 2.54–9.50) were significantly associated with acute diarrhea among children aged under two years.

Conclusion

To reduce acute diarrheal disease among children under two, priority should be given to interventions that focus on improving exclusive breastfeeding practices, regular cleaning of latrines, advocating for availability of handwashing facility within/around latrines, use of proper domestic sewage discharge methods and improving handwashing practice at the five critical times each day. Strengthening communication that promotes hygiene and behavioural change may also raise awareness among mothers/caregivers and empower them to enhance handwashing practices at critical times.
Literature
1.
go back to reference Unger A. Children’s health in slum settings. Arch Dis Child. 2013;98:799–805.CrossRef Unger A. Children’s health in slum settings. Arch Dis Child. 2013;98:799–805.CrossRef
2.
go back to reference Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151–61.CrossRef Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151–61.CrossRef
3.
go back to reference Riddle MS, DuPont HL, Connor BA. ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016;111(5):602–22.CrossRef Riddle MS, DuPont HL, Connor BA. ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016;111(5):602–22.CrossRef
4.
go back to reference Gerald TK, Olivier F, Alok B. et al. Diarrheal diseases. Disease control priorities in developing countries | Gerald T. Keusch, Olivier Fontaine, Alok Bhargava, and others. 2007;371–87. Gerald TK, Olivier F, Alok B. et al. Diarrheal diseases. Disease control priorities in developing countries | Gerald T. Keusch, Olivier Fontaine, Alok Bhargava, and others. 2007;371–87.
5.
go back to reference Christina MS, Blanca O. Diarrheal diseases FACG. 2007. Christina MS, Blanca O. Diarrheal diseases  FACG. 2007.
6.
go back to reference Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013;381(9875):1405–16.CrossRef Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013;381(9875):1405–16.CrossRef
7.
go back to reference WHO. Inheriting a sustainable world? Atlas on children’s health and the environment. Geneva: World Health Organization; 2017. WHO. Inheriting a sustainable world? Atlas on children’s health and the environment. Geneva: World Health Organization; 2017.
8.
go back to reference Luby S, Agboatwalla M, Hoekstra R, Rahbar M, Billhimer W, Keswick B. Delayed effectiveness of home-based interventions in reducing childhood diarrhea, Karachi, Pakistan. 2004;71(4):420–27. Am J Trop Med Hyg. 2004;71(4):420–7.CrossRef Luby S, Agboatwalla M, Hoekstra R, Rahbar M, Billhimer W, Keswick B. Delayed effectiveness of home-based interventions in reducing childhood diarrhea, Karachi, Pakistan. 2004;71(4):420–27. Am J Trop Med Hyg. 2004;71(4):420–7.CrossRef
9.
go back to reference Lule J, Mermin J. E J, Malambo S, downing R, ransom R, et al. effect of home-based water chlorination and safe storage on diarrhea among persons with human immunodeficiency virus in Uganda. Am J Trop Med Hyg. 2005;73(5):926–33.CrossRef Lule J, Mermin J. E J, Malambo S, downing R, ransom R, et al. effect of home-based water chlorination and safe storage on diarrhea among persons with human immunodeficiency virus in Uganda. Am J Trop Med Hyg. 2005;73(5):926–33.CrossRef
10.
go back to reference George CM, Perin J, De Calani KJN, Norman WR, Perry H, Davis TP Jr, et al. Risk factors for diarrhea in children under five years of age residing in peri-urban communities in Cochabamba, Bolivia. Am J Trop Med Hyg. 2014;91(6):1190–6.CrossRef George CM, Perin J, De Calani KJN, Norman WR, Perry H, Davis TP Jr, et al. Risk factors for diarrhea in children under five years of age residing in peri-urban communities in Cochabamba, Bolivia. Am J Trop Med Hyg. 2014;91(6):1190–6.CrossRef
11.
go back to reference Mulatya DM, Ochieng C. Disease burden and risk factors of diarrhoea in children under five years: evidence from Kenya's demographic health survey 2014. Int J Infect Dis. 2020;93:359–66 Mulatya DM, Ochieng C. Disease burden and risk factors of diarrhoea in children under five years: evidence from Kenya's demographic health survey 2014. Int J Infect Dis. 2020;93:359–66
12.
go back to reference Bado AR, Susuman AS, Nebie EI. Trends and risk factors for childhood diarrhea in sub-Saharan countries (1990–2013): assessing the neighborhood inequalities. Glob Health Action. 2016;9(1):30166.CrossRef Bado AR, Susuman AS, Nebie EI. Trends and risk factors for childhood diarrhea in sub-Saharan countries (1990–2013): assessing the neighborhood inequalities. Glob Health Action. 2016;9(1):30166.CrossRef
13.
go back to reference CSA, ICF-International. Ethiopia Demographic and Health Survey 2016. Addis Ababa, Ethiopia, and Calverton, Maryland, USA: Central Statistical Agency [Ethiopia] and ORC Macro2016. CSA, ICF-International. Ethiopia Demographic and Health Survey 2016. Addis Ababa, Ethiopia, and Calverton, Maryland, USA: Central Statistical Agency [Ethiopia] and ORC Macro2016.
14.
go back to reference Alebel A, Tesema C, Temesgen B, Gebrie A, Petrucka P, Kibret GD. Prevalence and determinants of diarrhea among under-five children in Ethiopia: a systematic review and meta-analysis. PLoS One. 2018;13(6):e0199684.CrossRef Alebel A, Tesema C, Temesgen B, Gebrie A, Petrucka P, Kibret GD. Prevalence and determinants of diarrhea among under-five children in Ethiopia: a systematic review and meta-analysis. PLoS One. 2018;13(6):e0199684.CrossRef
15.
go back to reference Adane M, Mengistie B, Kloos H, Medhin G, Mulat W. Sanitation facilities, hygienic conditions, and prevalence of acute diarrhea among under-five children in slums of Addis Ababa, Ethiopia: baseline survey of a longitudinal study. PLoS One. 2017;12(8):e0182783.CrossRef Adane M, Mengistie B, Kloos H, Medhin G, Mulat W. Sanitation facilities, hygienic conditions, and prevalence of acute diarrhea among under-five children in slums of Addis Ababa, Ethiopia: baseline survey of a longitudinal study. PLoS One. 2017;12(8):e0182783.CrossRef
16.
go back to reference Adane M, Mengistie B, Medhin G, Kloos H, Mulat W. Piped water supply interruptions and acute diarrhea among under-five children in Addis Ababa slums, Ethiopia: a matched case-control study. PLoS One. 2017;12(7):e0181516.CrossRef Adane M, Mengistie B, Medhin G, Kloos H, Mulat W. Piped water supply interruptions and acute diarrhea among under-five children in Addis Ababa slums, Ethiopia: a matched case-control study. PLoS One. 2017;12(7):e0181516.CrossRef
17.
go back to reference Dagnew AB, Tewabe T, Miskir Y, Eshetu T, Kefelegn W, Zerihun K, et al. Prevalence of diarrhea and associated factors among under-five children in Bahir Dar city, Northwest Ethiopia, 2016: a cross-sectional study. BMC Infect Dis. 2019;19(1):417.CrossRef Dagnew AB, Tewabe T, Miskir Y, Eshetu T, Kefelegn W, Zerihun K, et al. Prevalence of diarrhea and associated factors among under-five children in Bahir Dar city, Northwest Ethiopia, 2016: a cross-sectional study. BMC Infect Dis. 2019;19(1):417.CrossRef
18.
go back to reference MOH. Health Sector Transformation Plan (HSTP) 2015/16–2019/20, The Federal Democratic Republic of Ethiopia Ministry of Health. Addis Ababa. 2015. MOH. Health Sector Transformation Plan (HSTP) 2015/16–2019/20, The Federal Democratic Republic of Ethiopia Ministry of Health. Addis Ababa. 2015.
19.
go back to reference UN. The Sustainable Development Goals Report 2016. United Nations, New York 2016. UN. The Sustainable Development Goals Report 2016. United Nations, New York 2016.
20.
go back to reference Sarker AR, Sultana M, Mahumud RA, Sheikh N, Van Der Meer R, Morton A. Prevalence and health care–seeking behavior for childhood diarrheal disease in Bangladesh. Glob Pediatr Health. 2016;3:2333794X16680901.PubMedPubMedCentral Sarker AR, Sultana M, Mahumud RA, Sheikh N, Van Der Meer R, Morton A. Prevalence and health care–seeking behavior for childhood diarrheal disease in Bangladesh. Glob Pediatr Health. 2016;3:2333794X16680901.PubMedPubMedCentral
21.
go back to reference Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, S P, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study. Lancet. 2013;382(9888):209–22.CrossRef Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, S P, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study. Lancet. 2013;382(9888):209–22.CrossRef
22.
go back to reference CSA. Population Projection of Ethiopia for All Regions At Wereda Level from 2014–2017 Central Statistical Agency 2017. CSA. Population Projection of Ethiopia for All Regions At Wereda Level from 2014–2017 Central Statistical Agency 2017.
23.
go back to reference WHO. The treatment of diarrhea. A manual for physicians and other senior health workers. Department of Child and Adolescent Health and Development. Geneva: World Health Organization; 2005. WHO. The treatment of diarrhea. A manual for physicians and other senior health workers. Department of Child and Adolescent Health and Development. Geneva: World Health Organization; 2005.
24.
go back to reference Farthing M, Salam M, Lindberg G, Dite P, Khalit I, Lindo S, et al. World Gastroenterology Organization Global Guidelines. Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organization; 2012. p. 1–24. Farthing M, Salam M, Lindberg G, Dite P, Khalit I, Lindo S, et al. World Gastroenterology Organization Global Guidelines. Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organization; 2012. p. 1–24.
25.
go back to reference Schlesselman J, Stolley P. Case-control studies: design, conduct, analysis. Oxford: Oxford University Press; 1982. p. 144–70. Schlesselman J, Stolley P. Case-control studies: design, conduct, analysis. Oxford: Oxford University Press; 1982. p. 144–70.
26.
go back to reference Breurec S, Vanel N, Bata P, Chartier L, Farra A, Favennec L, et al. Etiology and epidemiology of diarrhea in hospitalized children from low income country: a matched case -control study in Central African Republic. PLoS Negl Trop Dis. 2016;10(1):e0004283.CrossRef Breurec S, Vanel N, Bata P, Chartier L, Farra A, Favennec L, et al. Etiology and epidemiology of diarrhea in hospitalized children from low income country: a matched case -control study in Central African Republic. PLoS Negl Trop Dis. 2016;10(1):e0004283.CrossRef
27.
go back to reference Adane M, Mengistie B, Mulat W, Medhin G, Kloos H. The most important recommended times of hand washing with soap and water in preventing the occurrence of acute diarrhea among children under five years of age in slums of Addis Ababa, Ethiopia. J Community Health. 2018;43(2):400–5.CrossRef Adane M, Mengistie B, Mulat W, Medhin G, Kloos H. The most important recommended times of hand washing with soap and water in preventing the occurrence of acute diarrhea among children under five years of age in slums of Addis Ababa, Ethiopia. J Community Health. 2018;43(2):400–5.CrossRef
28.
go back to reference WHO, UNICEF. Core Questions on Drinking Water and Sanitation for Household Surveys. JMP Publication of the World Health Organizations and United Nations Children Fund. Switzerland. Geneva: WHO; 2006. WHO, UNICEF. Core Questions on Drinking Water and Sanitation for Household Surveys. JMP Publication of the World Health Organizations and United Nations Children Fund. Switzerland. Geneva: WHO; 2006.
29.
go back to reference Kasee LF, Merrom OS, Hassa HY. Assessment of the prevalence of diarrheal disease under-five children Serbo town, Jimma zone south West Ethiopia. Clin Mother Child Health. 2018;15(1).1000280. Kasee LF, Merrom OS, Hassa HY. Assessment of the prevalence of diarrheal disease under-five children Serbo town, Jimma zone south West Ethiopia. Clin Mother Child Health. 2018;15(1).1000280.
30.
go back to reference Diouf K, Tabatabai P, Rudolph J, Marx M. Diarrhoea prevalence in children under five years of age in rural Burundi: an assessment of social and behavioural factors at the household level. Glob Health Action. 2014;7:24895. Diouf K, Tabatabai P, Rudolph J, Marx M. Diarrhoea prevalence in children under five years of age in rural Burundi: an assessment of social and behavioural factors at the household level. Glob Health Action. 2014;7:24895.
31.
go back to reference Rohmawati N, Panza A, Lertmaharit S. Factors associated with diarrhea among children under five years of age in Banten Province, Indonesia. J Health Res. 2012;26(1):31–4. Rohmawati N, Panza A, Lertmaharit S. Factors associated with diarrhea among children under five years of age in Banten Province, Indonesia. J Health Res. 2012;26(1):31–4.
32.
go back to reference Hashi A, Kumie A, Gasana J. Prevalence of diarrhoea and associated factors among under-five children in Jigjiga District, Somali region, Eastern Ethiopia. Open J Prev Med. 2016;6(10):233–46.CrossRef Hashi A, Kumie A, Gasana J. Prevalence of diarrhoea and associated factors among under-five children in Jigjiga District, Somali region, Eastern Ethiopia. Open J Prev Med. 2016;6(10):233–46.CrossRef
33.
go back to reference Kolahi AA, NABAVI M, Sohrabi MR. Epidemiology of acute diarrheal diseases among children under 5 years of age in Tehran, Iran. Iran J Clin Infect Dis. 2008;3(4):193–8. Kolahi AA, NABAVI M, Sohrabi MR. Epidemiology of acute diarrheal diseases among children under 5 years of age in Tehran, Iran. Iran J Clin Infect Dis. 2008;3(4):193–8.
34.
go back to reference Gizaw Z, Woldu W, Bitew BD. Child feeding practices and diarrheal disease among children less than two years of age of the nomadic people in Hadaleala District, Afar region, Northeast Ethiopia. Int Breastfeed J. 2017;12(1):24.CrossRef Gizaw Z, Woldu W, Bitew BD. Child feeding practices and diarrheal disease among children less than two years of age of the nomadic people in Hadaleala District, Afar region, Northeast Ethiopia. Int Breastfeed J. 2017;12(1):24.CrossRef
35.
go back to reference Asfaha KF, Tesfamichael FA, Fisseha GK, Misgina KH, Weldu MG, Welehaweria NB, et al. Determinants of childhood diarrhea in Medebay Zana District, Northwest Tigray, Ethiopia: a community based unmatched case–control study. BMC Pediatr. 2018;18:120. Asfaha KF, Tesfamichael FA, Fisseha GK, Misgina KH, Weldu MG, Welehaweria NB, et al. Determinants of childhood diarrhea in Medebay Zana District, Northwest Tigray, Ethiopia: a community based unmatched case–control study. BMC Pediatr. 2018;18:120.
36.
go back to reference Getachew A, Guadu T, Tadie A, Gizaw Z, Gebrehiwot M, Cherkos DH, et al. Diarrhea prevalence and sociodemographic factors among under-five children in rural areas of North Gondar zone, Northwest Ethiopia. Int J Pediatr. 2018;2018. https://doi.org/10.1155/2018/6031594. Getachew A, Guadu T, Tadie A, Gizaw Z, Gebrehiwot M, Cherkos DH, et al. Diarrhea prevalence and sociodemographic factors among under-five children in rural areas of North Gondar zone, Northwest Ethiopia. Int J Pediatr. 2018;2018. https://​doi.​org/​10.​1155/​2018/​6031594
37.
go back to reference Ogbo FA, Agho K, Ogeleka P, Woolfenden S, Page A, Eastwood J, et al. Infant feeding practices and diarrhoea in sub-Saharan African countries with high diarrhoea mortality. PLoS One. 2017;12(2):e0171792.CrossRef Ogbo FA, Agho K, Ogeleka P, Woolfenden S, Page A, Eastwood J, et al. Infant feeding practices and diarrhoea in sub-Saharan African countries with high diarrhoea mortality. PLoS One. 2017;12(2):e0171792.CrossRef
38.
go back to reference Bizuneh H, Getnet F, Meressa B, Tegene Y, Worku G. Factors associated with diarrheal morbidity among under-five children in Jigjiga town, Somali Regional State, eastern Ethiopia: a cross-sectional study. BMC pediatrics. 2017;17:182. Bizuneh H, Getnet F, Meressa B, Tegene Y, Worku G. Factors associated with diarrheal morbidity among under-five children in Jigjiga town, Somali Regional State, eastern Ethiopia: a cross-sectional study. BMC pediatrics. 2017;17:182.
39.
go back to reference WHO. End preventable deaths: Global Action Plan for Prevention and Control of Pneumonia and Diarrhoea.: World Health Organization/The United Nations Children’s Fund (UNICEF) 2013. WHO. End preventable deaths: Global Action Plan for Prevention and Control of Pneumonia and Diarrhoea.: World Health Organization/The United Nations Children’s Fund (UNICEF) 2013.
40.
go back to reference Asnakew DT, Teklu MG, Woreta SA. Prevalence of diarrhea among under-five children in health extension model households in Bahir Dar Zuria district, North-Western Ethiopia. Edorium J Public Health. 2017;4:1–9. Asnakew DT, Teklu MG, Woreta SA. Prevalence of diarrhea among under-five children in health extension model households in Bahir Dar Zuria district, North-Western Ethiopia. Edorium J Public Health. 2017;4:1–9.
41.
go back to reference Regassa W, Lemma S. Assessment of diarrheal disease prevalence and associated risk factors in children of 6-59 months old at Adama District rural Kebeles, eastern Ethiopia, January/2015. Ethiop J Health Dev. 2016;26(6):581–8.CrossRef Regassa W, Lemma S. Assessment of diarrheal disease prevalence and associated risk factors in children of 6-59 months old at Adama District rural Kebeles, eastern Ethiopia, January/2015. Ethiop J Health Dev. 2016;26(6):581–8.CrossRef
42.
go back to reference WMA. World Medical Associations Declaration of Helsinki. Ethical principles for medical research involving human subjects, 6th revision. Helsinki, Finland. 2008. WMA. World Medical Associations Declaration of Helsinki. Ethical principles for medical research involving human subjects, 6th revision. Helsinki, Finland. 2008.
Metadata
Title
Priorities for intervention to prevent diarrhea among children aged 0–23 months in northeastern Ethiopia: a matched case-control study
Authors
Alemwork Baye
Metadel Adane
Tadesse Sisay
Habtamu Shimels Hailemeskel
Publication date
01-12-2021
Publisher
BioMed Central
Keywords
Diarrhea
Diarrhea
Published in
BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-021-02592-5

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