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BMC Pediatrics
Published in: BMC Pediatrics 1/2019

Open Access 01-12-2019 | Study protocol

The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants

Authors: Gaston Ofman, Mauricio T. Caballero, Damian Alvarez Paggi, Jacqui Marzec, Florencia Nowogrodzki, Hye-Youn Cho, Mariana Sorgetti, Guillermo Colantonio, Alejandra Bianchi, Luis M. Prudent, Nestor Vain, Gonzalo Mariani, Jorge Digregorio, Elba Lopez Turconi, Cristina Osio, Fernanda Galletti, Mariangeles Quiros, Andrea Brum, Santiago Lopez Garcia, Silvia Garcia, Douglas Bell, Marcus H. Jones, Trent E. Tipple, Steven R. Kleeberger, Fernando P. Polack

Published in: BMC Pediatrics | Issue 1/2019

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Abstract

Background

Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210–213, 2017; Isayama et la., JAMA Pediatr 171:271–279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease.

Methods

The Discovery BPD (D-BPD) Program involves a cohort of infants < 1,250 g at birth prospectively followed until 6 years of age. The program integrates analysis of detailed clinical data by machine learning, genetic susceptibility and molecular translation studies.

Discussion

The current gap in understanding BPD as a complex multi-trait spectrum of different disease endotypes will be addressed by a bedside-to-bench and bench-to-bedside approach in the D-BPD program. The D-BPD will provide enhanced understanding of mechanisms, evolution and consequences of lung diseases in preterm infants. The D-BPD program represents a unique opportunity to combine the expertise of biologists, neonatologists, pulmonologists, geneticists and biostatisticians to examine the disease process from multiple perspectives with a singular goal of improving outcomes of premature infants.

Trial registration

Does not apply for this study.
Appendix
Available only for authorised users
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Metadata
Title
The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants
Authors
Gaston Ofman
Mauricio T. Caballero
Damian Alvarez Paggi
Jacqui Marzec
Florencia Nowogrodzki
Hye-Youn Cho
Mariana Sorgetti
Guillermo Colantonio
Alejandra Bianchi
Luis M. Prudent
Nestor Vain
Gonzalo Mariani
Jorge Digregorio
Elba Lopez Turconi
Cristina Osio
Fernanda Galletti
Mariangeles Quiros
Andrea Brum
Santiago Lopez Garcia
Silvia Garcia
Douglas Bell
Marcus H. Jones
Trent E. Tipple
Steven R. Kleeberger
Fernando P. Polack
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2019
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-019-1610-8

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