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BMC Pediatrics
Published in: BMC Pediatrics 1/2018

Open Access 01-12-2018 | Research article

Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children

Authors: Anh Thi Nguyet Nguyen, Muneko Nishijo, Tai The Pham, Nghi Ngoc Tran, Anh Hai Tran, Luong Van Hoang, Hitomi Boda, Yuko Morikawa, Yoshikazu Nishino, Hisao Nishijo

Published in: BMC Pediatrics | Issue 1/2018

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Abstract

Background

We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children’s eating behavior, which is often altered in those with developmental disorders.

Methods

A total of 185 mother-and-child pairs previously enrolled in a birth cohort in dioxin-contaminated areas participated in this survey, conducted when the children reached 3 years of age. Perinatal dioxin exposure levels in the children were estimated using dioxin levels in maternal breast milk after birth. Mothers were interviewed using the Children’s Eating Behaviour Questionnaire (CEBQ). A multiple linear regression model was used to analyze the association between dioxin exposure and CEBQ scores, after controlling for covariates such as location, parity, maternal age, maternal education, maternal body mass index, family income, children’s gestational age at delivery, and children’s age at the time of the survey. A general linear model was used to analyze the effects of sex and dioxin exposure on CEBQ scores.

Results

There was no significant association between most dioxin congeners or toxic equivalencies of polychlorinated dibenzo-p-dioxins/furans (TEQ-PCDDs/Fs) and CEBQ scores in boys, although significant associations between some eating behavior sub-scores and 1,2,3,4,6,7,8,9-octachlorodibenzofuran were observed. In girls, there was a significant inverse association between levels of TEQ-PCDFs and enjoyment of food scores and between levels of TEQ-PCDFs and TEQ-PCDDs/Fs and desire to drink scores. Two pentachlorodibenzofuran congeners and 1,2,3,6,7,8-hexachlorodibenzofuran were associated with a decreased enjoyment of food score, and seven PCDF congeners were associated with a decreased desire to drink score. The adjusted mean enjoyment of food score was significantly lower in children of both sexes exposed to high levels of TEQ-PCDFs. There was, however, a significant interaction between sex and TEQ-PCDF exposure in their effect on desire to drink scores, especially in girls.

Conclusions

Perinatal exposure to dioxin can influence eating behavior in children and particularly in girls. A longer follow-up study would be required to assess whether emotional development that affects eating styles and behaviors is related to dioxin exposure.
Appendix
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Literature
1.
2.
Schecter A, Hoang TQ, Päpke O, Tung KC, Constable JD. Agent Orange, dioxins, and other chemicals of concern in Vietnam: update 2006. J Occup Environ Med. 2006;48:408–13.CrossRefPubMed
3.
Mai TA, Doan TV, Tarradellas J, Felippe de Alencastro L, Grandjean D. Dioxin contamination in soils of southern Vietnam. Chemosphere. 2007;67:1802–7.CrossRefPubMed
4.
5.
Tai PT, Nishijo M, Kido T, Nakagawa H, Maruzeni S, Anh NTN, et al. Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide spraying. Environ Sci Technol. 2011;45:6625–32.CrossRefPubMed
6.
Nishijo M, Tai PT, Nakagawa H, Maruzeni S, Anh NTN, Luong HV, et al. Impact of perinatal dioxin exposure on infant growth: a cross-sectional and longitudinal studies in dioxin-contaminated areas in Vietnam. PLoS One. 2012;7:e4027.CrossRef
7.
Pham TT, Nishijo M, Nguyen TNA, Maruzeni S, Nakagawa H, Luong HV, et al. Dioxin exposure in breast milk and infant neurodevelopment in Vietnam. Occup Environ Med. 2013;70:656–62.CrossRef
8.
Pham TT, Nishijo M, Nguyen AT, Tran NN, Hoang VL, Tran AH, et al. Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1 year of age. Sci Total Environ. 2015;536:575–81.CrossRefPubMed
9.
Nishijo M, Tai PT, Nguyen TNA, Nghi TN, Nakagawa H, Luong HV, et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam. Mol Psychiatry. 2014;19:1220–6.CrossRefPubMed
10.
Tai PTNM, Nghi TN, Nakagawa H, Van Luong H, Anh TH, Nishijo H. Effects of perinatal dioxin exposure on development of children during the first 3 years of life. J Pediatr. 2016;175:159–66.CrossRefPubMed
11.
Schreck KA, Williams K, Smith AF. A comparison of eating behaviors between children with and without autism. J Autism Dev Disord. 2004;34:433–8.CrossRefPubMed
12.
Martins Y, Young RL, Robson DC. Feeding and eating behaviors in children with autism and typically developing children. J Autism Dev Disord. 2008;38(10):1878–87.
13.
Tuomisto JT, Pohjanvirta R, Unkila M, Tuomisto J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced anorexia and wasting syndrome in rats: aggravation after ventromedial hypothalamic lesion. Eur J Pharmacol. 1995;293:309–17.CrossRefPubMed
14.
Nguyen AT, Nishijo M, Hori E, Nguyen NM, Pham TT, Fukunaga K, et al. Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspring rats. Environ Health Insights. 2013;7:1–14.CrossRefPubMedPubMedCentral
15.
Nguyen MN, Nishijo M, Nguyen AT, Bor A, Nakamura T, Hori E, et al. Effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on parvalbumin- and calbindin-immunoreactive neurons in the limbic system and superior colliculus in rat offspring. Toxicology. 2013;314:125–34.CrossRefPubMed
16.
Bor A, Nishijo M, Nishimaru H, Nakamura T, Tran NN, Van Le Q, et al. Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor β in the rat brain. J Integr Neurosci. 2017;16:453–70.CrossRefPubMed
17.
Berridge KC, Ho CY, Richard JM, DiFeliceantonio AG. The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res. 2010;1350:43–64.CrossRefPubMedPubMedCentral
18.
Shott ME, Cornier MA, Mittal VA, Pryor TL, Orr JM, Brown MS, Frank GK. Orbitofrontal cortex volume and brain reward response in obesity. Int J Obes. 2015;39:214–21.CrossRef
19.
20.
Hang NM, Saito M, Son LK. Technology selection – principles and progress – for dioxin hotspot remediation in Vietnam. In: The Office of National Steering Committee 33, editor. Proceedings for Vietnamese session in 33rd international symposium on halogenated persistent organic pollutants and POPs –DIOXIN 2013. Hanoi: Office 33; 2013. p.3–6.
21.
Wardle J, Guthrie CA, Sanderson S, Rapoport L. Development of the Children's eating behavior questionnaire. J Child Psychol Psychiatry. 2001;42:963–70.CrossRefPubMed
22.
Van den Berg M, Birnbaum LS, Denison M, Vito MD, Farland W, Feeley M, et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci. 2006;93:223–41.CrossRefPubMedPubMedCentral
23.
Viana V, Sinde S, Saton JC. Children’s eating behavior questionnaire: associations with BMI in Portuguese children. Bri J Nutr. 2008;100:445–50.CrossRef
24.
Sleddens EFC, Kremers SPJ, Thijs C. The Children's eating behaviour questionnaire: factorial validity and association with body mass index in Dutch children aged 6–7. Int J Behav Nutr Phys Act. 2008;5:49.CrossRefPubMedPubMedCentral
25.
Nadon G, Feldman DE, Dunn W, Gisel E. Association of sensory processing and eating problems in children with autism spectrum disorders. Autism Res Treat. 2011;2011:541926.PubMedPubMedCentral
26.
Miner P, Borkuhova Y, Shimonova L, Khaimov A, Bodnar RJ. GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegamental area and nucleus accumbens shell in rats: reciprocal and regional interactions. Brain Res. 2010;1355:86–96.CrossRefPubMed
27.
Hays LE, Carpenter CD, Petersen SL. Evidence that GABAergic neurons in the preoptic area of the rat brain are targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin during development. Environ Health Perspect. 2002;110:369–76.CrossRefPubMedPubMedCentral
28.
Amin S, Moore RW, Peterson RE, Schantz SL. Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats. Neurotoxicol Teratol. 2000;22:675–82.CrossRefPubMed
29.
Tsukimori K, Uchin H, Mitoma C, Yasukawa F, Chiba T, et al. Marternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease. Environ Int. 2012;38:79–86.CrossRefPubMed
30.
Vreugdenhil HJI, Slijper FME, Mulder PGH, Weisglas-Kuperus N. Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age. Environ Health Perspect. 2002;110:A593–8.CrossRefPubMedPubMedCentral
31.
Remy E, Issanchou S, Chabanet C, Boggio V, Nicklaus S. Impact of adiposity, age, sex and maternal feeding practices on eating in the absence of hunger and caloric compensation in preschool children. Int J Obes. 2015;39:925–30.CrossRef
32.
Kimura S, Endo Y, Minamimae K, Kanzaki S, Hanaki K. Gender differences in childhood food preference: evaluation using a subjective picture choice method. Pediatr Int. 2014;56:389–94.CrossRefPubMed
33.
Migraine A, Nicklaus S, Parnet P, Lange C, Monnery-Patris S, Des Robert C, Darmaum D, Flamant C, Amrger V, Roze JC. Effect of preterm birth and birth weight on eating behavior at 2 y of age. Am J Clin Nutr. 2013;97:1270–7.CrossRefPubMed
34.
Carper JL, Fisher JO, Birch LL. Young girls' emerging dietary restraint and disinhibition are related to parental control in child feeding. Appetite. 2000;35:121–9.CrossRefPubMed
35.
Nordin S, Broman DA, Garvill J, Nyroos M. Gender difference in factors affecting rejection of food in healthy young Swedish adults. Appetite. 2004;43:295–301.CrossRefPubMed
36.
Nguyen TNA, Nishijo M, Pham TT, Maruzeni S, Morikawa Y, Tran HA, et al. Maternal risk factors associated with increased dioxin concentrations in breast milk in a hot spot of dioxin contamination in Vietnam. J Expo Sci Environ Epidemiol. 2014;24:489–96.CrossRef
Metadata
Title
Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children
Authors
Anh Thi Nguyet Nguyen
Muneko Nishijo
Tai The Pham
Nghi Ngoc Tran
Anh Hai Tran
Luong Van Hoang
Hitomi Boda
Yuko Morikawa
Yoshikazu Nishino
Hisao Nishijo
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2018
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-018-1171-2

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