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BMC Pediatrics

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Open Access 01-12-2018 | Research article

Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia

Authors: Shahrokh Mehrpisheh, Azadeh Memarian, Abolfazl Mahyar, Negin Sadat Valiahdi

Published in: BMC Pediatrics | Issue 1/2018

Abstract

Background

Considering the significant prevalence of Neonatal Indirect Hyperbilirubinemia (NIH) and its irreversible neurological complications, identifying the factors involved in the prevalence of neonatal jaundice is essential. The present study was conducted to determine the relationship between serum vitamin D levels and the prevalence of NIH in infants admitted to Qods Hospital of Qazvin in Iran in 2015–16.

Methods

In this case-control study, 30 term infants with NIH (the case group) were compared with 30 healthy, non- icteric, term infants (the control group) in terms of serum levels of 25-hydroxyvitamin D. The results were analyzed and compared between the two groups using t-test and the Chi-square test.

Results

The mean and standard deviation of serum 25-hydroxyvitamin D levels were 10.76 ± 8.6 ng/dl in the case group and 14.88 ± 11.38 ng/dl in the control group. There were no significant differences between the two groups (P = 0.11).

Conclusion

The results suggest the lack of a relationship between vitamin D levels and NIH. However, further prospective studies are needed to conclude that vitamin D has no role in the pathogenesis of NIH.

Koosha A, Rafizadeh B. Evaluation of neonatal indirect hyperbilirubinaemia at Zanjan Province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency. Singap Med J. 2007;48:424–8. https://www.ncbi.nlm.nih.gov/pubmed/17453100.

Weng YH, Chiu YW. Clinical characteristics of G6PD deficiency in infants with marked hyperbilirubinemia. J Pediatr Hematol Oncol. 2010;32:11–4. https://doi.org/10.1097/MPH.0b013e3181c09aec. www.ncbi.nlm.nih.gov/pubmed/20051781 CrossRefPubMed

Agrawal SK, Kumar P, Rathi R, Sharma N, Das R, Prasad R, et al. UGT1A1 gene polymorphisms in north Indian neonates presenting with unconjugated hyperbilirubinemia. Pediatr Res. 2009;65:675–80. https://doi.org/10.1203/PDR.0b013e31819ed5de. www.ncbi.nlm.nih.gov/pubmed/19430380 CrossRefPubMed

Squires J, Balistreri W. Manifestations of liver disease. In: Nelson textbook of pediatrics. 355. 20th ed. Philadelphia: Mosby Elsevier; 2016. p. 1922–3.

English M, Ngama M, Musumba C, Wamola B, Bwika J, Mohammed S, et al. Causes and outcome of young infant admissions to a Kenyan district hospital. Arch Dis Child. 2003;88:438–43.CrossRefPubMedPubMedCentral

Kuzniewicz MW, Wickremasinghe AC, Wu YW, McCulloch CE, Walsh EM, Wi S, et al. Prevalence, etiology, and outcomes of hazardous hyperbilirubinemia in newborns. Pediatrics. 2014;134:504–9.CrossRefPubMed

Hochberg Z. Rickets-past and present. In: Hochberg Z, editor. Vitamin D and rickets. Switzerland: Karger Publishers; 2003. p. 1–3.

Hyperbilirubinemia AAoPSo. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297.CrossRef

Fanaroff AAM, Fanaroff RJAA, Martin RJ. Neonatal-perinatal medicine: diseases of the fetus and infant. Missouri: Mosby; 2002.

10.

Özkan B, Döneray H. The non-skeletal effects of vitamin D. Çocuk Saǧlıǧı ve Hastalıkları Dergisi. 2011;53:99–119.

11.

Wong R, Desandre G, Sibley E, Stevenson D. Neonatal jaundice and liver disease. In: Martin R, Fanoroff A, Walsh M, editors. Fanaroff and Martin’s neonatal-Peinatal medicine diseases of the fetus and infant. Philadelphia: Mosby Elsevier; 2006. p. 1419–65.

12.

Aletayeb SM, Dehdashtiyan M, Aminzadeh M, Malekyan A, Jafrasteh S. Comparison between maternal and neonatal serum vitamin D levels in term jaundiced and nonjaundiced cases. J Chin Med Assoc. 2016;79:614–7. https://doi.org/10.1016/j.jcma.2016.05.008. www.ncbi.nlm.nih.gov/pubmed/27633666 CrossRefPubMed

13.

Weinert LS, Reichelt AJ, Schmitt LR, Boff R, Oppermann ML, Camargo JL, et al. Vitamin D deficiency increases the risk of adverse neonatal outcomes in gestational diabetes. PLoS One. 2016;11:e0164999. https://doi.org/10.1371/journal.pone.0164999. www.ncbi.nlm.nih.gov/pubmed/27764194 CrossRefPubMedPubMedCentral

14.

Holick M, Vitamin D, Deficiency N, Engl J. Med. 2007;357:266–81. Review

15.

Watchko JF. Identification of neonates at risk for hazardous hyperbilirubinemia: emerging clinical insights. Pediatr Clin N Am. 2009;56:671–87.CrossRef

16.

Rennie J, Burman-Roy S, Murphy MS, Group GD. Neonatal jaundice: summary of NICE guidance. BMJ. 2010;340:c2409.CrossRefPubMed

17.

Sperling M. Synthesis and biologic activity of vitamin D. In: MA. S, editor. Pediatric endocrinology. 4th ed. Philadelphia: Mosby Elsevier; 2014. p. 231–5.

18.

Wu T, Fung K, Wu J, Yang C, Weisel R. Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem Pharmacol. 1996;51:859–62.CrossRefPubMed

19.

Mutlu M, Çayir A, Çayir Y, Özkan B, Aslan Y. Vitamin D and hyperbilirubinaemia in neonates. HK J Paediatr (new series). 2013;18:77–81.

20.

Dan-Ierodiaconou E, Mengreli C, Pantelakis S, Lapatsanis P. The effect of phototherapy on neonatal vitamin D metabolism. Pediatr Res. 1980;14:1418.

21.

Travadi J, Simmer K, Ramsay J, Doherty D, Hagan R. Patent ductus arteriosus in extremely preterm infants receiving phototherapy: does shielding the chest make a difference? A randomized, controlled trial. Acta Paediatr. 2006;95:1418–23.CrossRefPubMed

22.

Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122:398–417.CrossRefPubMed

23.

Gillies D, Hay A, Sheltawy M, Congdon P. Effect of phototherapy on plasma 25 (OH)-vitamin D in neonates. Neonatology. 1984;45:225–7.CrossRef

Title: Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia
Authors: Shahrokh Mehrpisheh
Azadeh Memarian
Abolfazl Mahyar
Negin Sadat Valiahdi
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Pediatrics / Issue 1/2018
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-018-1140-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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