Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Pediatrics
Published in: BMC Pediatrics 1/2018

Open Access 01-12-2018 | Research article

Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

Authors: Cécile Delecroix, Raja Brauner, Jean-Claude Souberbielle

Published in: BMC Pediatrics | Issue 1/2018

Login to get access

Abstract

Background

Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) serum levels and patient characteristics.

Methods

A retrospective single-center study of 25OHD and 1,25(OH)2D serum concentrations in 50 children with PSIS at the initial evaluation before treatment.

Results

Mean concentrations of 33.2 ± 18.0 ng/mL for 25OHD and 74.5 ± 40.7 ng/L for 1,25(OH)2D were measured. Additionally, 25OHD concentrations were significantly higher in boys than in girls (p = 0.04) and lower in the cold season than in the sunny season (p = 0.03). Significant positive correlations were observed between the GH peak and serum 1,25 (OH) 2D concentrations (Rho = 0.35; p = 0.015) and the 1,25(OH)2D/25OHD ratio (Rho = 0.29; p < 0.05). No correlation was found for other characteristics, including IGF1.

Conclusions

Vitamin D status in children with hypothalamic-pituitary deficiency due to PSIS was similar to that reported in national and European studies in healthy children. The positive significant correlations between the GH peak and the 1,25 (OH)2D concentration as well as with the 1,25 (OH)2D/25OHD ratio suggest that even in these patients who had severely impaired GH secretion and low IGF1 levels, an interplay between the GH/IGF1 axis and the vitamin D system still exists.
Literature
1.
Argyropoulou M, Perignon F, Brauner R, Brunelle F. Magnetic resonance imaging in the diagnosis of growth hormone deficiency. J Pediatr. 1992;120:886–91.CrossRefPubMed
2.
Pham L-L, Lemaire P, Harroche A, Souberbielle J-C, Brauner R. Pituitary stalk interruption syndrome in 53 postpubertal patients: factors influencing the heterogeneity of its presentation. PLoS One. 2013;8:e53189.CrossRefPubMedPubMedCentral
3.
Dupuis-Girod S, Gluckman E, Souberbielle JC, Brauner R. Growth hormone deficiency caused by pituitary stalk interruption in Fanconi’s anemia. J Pediatr. 2001;138:129–33.CrossRefPubMed
4.
Leblanc T, Gluckman E, Brauner R. Growth hormone deficiency caused by pituitary stalk interruption in diamond-Blackfan anemia. J Pediatr. 2003;142:358.CrossRefPubMed
5.
Pinto G, Netchine I, Sobrier ML, Brunelle F, Souberbielle JC, Brauner R. Pituitary stalk interruption syndrome: a clinical-biological-genetic assessment of its pathogenesis. J Clin Endocrinol Metab. 1997;82:3450–4.PubMed
6.
Reynaud R, Gueydan M, Saveanu A, Vallette-Kasic S, Enjalbert A, Brue T, et al. Genetic screening of combined pituitary hormone deficiency: experience in 195 patients. J Clin Endocrinol Metab. 2006;91:3329–36.CrossRefPubMed
7.
Bashamboo A, Bignon-Topalovic J, Moussi N, McElreavey K, Brauner R. Mutations in the human ROBO1 gene in pituitary stalk interruption syndrome. J Clin Endocrinol Metab. July 2017;102(7):2401–6.CrossRefPubMed
8.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.CrossRefPubMed
9.
Souberbielle J-C, Massart C, Brailly-Tabard S, Cavalier E, Chanson P. Prevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study. Endocrine. 2016;53:543–50.CrossRefPubMed
10.
Whiting SJ, Langlois KA, Vatanparast H, Greene-Finestone LS. The vitamin D status of Canadians relative to the 2011 dietary reference intakes: an examination in children and adults with and without supplement use. Am J Clin Nutr. 2011;94:128–35.CrossRefPubMed
11.
Mallet E, Gaudelus J, Reinert P, Stagnara J, Benichou J, Basuyau J-P, et al. [vitamin D status in 6- to 10-year-old children: a French multicenter study in 326 children]. Arch. Pediatr. Organe off. Soc. Francaise Pediatr. 2014;21:1106–14.
12.
13.
Gilbert-Diamond D, Baylin A, Mora-Plazas M, Marin C, Arsenault JE, Hughes MD, et al. Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am J Clin Nutr. 2010;92:1446–51.CrossRefPubMedPubMedCentral
14.
15.
Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev. 2012;12:127–36.CrossRefPubMed
16.
Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010;106:963–8.CrossRefPubMed
17.
Ameri P, Giusti A, Boschetti M, Murialdo G, Minuto F, Ferone D. Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin Endocrinol. 2013;79:457–63.CrossRef
18.
Soliman AT, Al Khalaf F, Alhemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism. 2008;57:95–102.CrossRefPubMed
19.
Wei S, Tanaka H, Kubo T, Ono T, Kanzaki S, Seino Y. Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency. Eur J Endocrinol Eur Fed Endocr Soc. 1997;136:45–51.CrossRef
20.
Saggese G, Baroncelli GI, Bertelloni S, Cinquanta L, Di Nero G. Effects of long-term treatment with growth hormone on bone and mineral metabolism in children with growth hormone deficiency. J Pediatr. 1993;122:37–45.CrossRefPubMed
21.
Sempé M, Pédron G, Roy-Pernot MP. Auxologie, méthode et séquence. Paris: Théraplix; 1979.
22.
Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A. Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr. 1991;45:13–21.PubMed
23.
Greulich W, Pyle S. Radiographic atlas of skeletal development of the hand and wrist. Stanford: University Press; 1959.
24.
Vidailhet M, Mallet E. Vitamin D in childhood. Presse Medicale Paris Fr 1983. 2013;42:1383–90.
25.
Saggese G, Vierucci F, Boot AM, Czech-Kowalska J, Weber G, CAJ C, et al. Vitamin D in childhood and adolescence: an expert position statement. Eur J Pediatr. 2015;174:565–76.CrossRefPubMed
26.
Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1587–609.CrossRefPubMed
27.
Souberbielle J-C, Body J-J, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev. 2010;9:709–15.CrossRefPubMed
28.
Esterle L, Nguyen M, Walrant-Debray O, Sabatier J-P, Garabedian M. Adverse interaction of low-calcium diet and low 25(OH)D levels on lumbar spine mineralization in late-pubertal girls. J Bone Miner Res Off J Am Soc Bone Miner Res. 2010;25:2392–8.CrossRef
29.
Gonzalez-Gross M, Valtuena J, Breidenassel C, Moreno LA, Ferrari M, Kersting M, et al. Vitamin D status among adolescents in Europe: the healthy lifestyle in Europe by nutrition in adolescence study. Br J Nutr. 2012;107:755–64.CrossRefPubMed
30.
Valtuena J, Gonzalez-Gross M, Huybrechts I, Breidenassel C, Ferrari M, Mouratidou T, et al. Factors associated with vitamin D deficiency in European adolescents: the HELENA study. J Nutr Sci Vitaminol (Tokyo). 2013;59:161–71.CrossRef
31.
Ciresi A, Ciccio F, Giordano C. High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment. J Endocrinol Investig. 2014;37:631–8.CrossRef
32.
Witkowska-Sedek E, Kucharska A, Ruminska M, Pyrzak B. Relationship between 25(OH)D and IGF-I in children and adolescents with growth hormone deficiency. Adv Exp Med Biol. 2016;912:43–9.CrossRefPubMed
33.
Savanelli MC, Scarano E, Muscogiuri G, Barrea L, Vuolo L, Rubino M, et al. Cardiovascular risk in adult hypopituitaric patients with growth hormone deficiency: is there a role for vitamin D? Endocrine. 2016;52:111–9.CrossRefPubMed
34.
Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, et al. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol. 2013;169:767–72.CrossRefPubMed
35.
Vidailhet M, Mallet E, Bocquet A, Bresson J-L, Briend A, Chouraqui J-P, et al. Vitamin D: still a topical matter in children and adolescents. A position paper by the committee on nutrition of the French Society of Paediatrics. Arch Pediatr Organe Off Soc Francaise Pediatr. 2012;19:316–28.
36.
Condamine L, Menaa C, Vrtovsnik F, Friedlander G, Garabedian M. Local action of phosphate depletion and insulin-like growth factor 1 on in vitro production of 1,25-dihydroxyvitamin D by cultured mammalian kidney cells. J Clin Invest. 1994;94:1673–9.CrossRefPubMedPubMedCentral
37.
Wei S, Tanaka H, Seino Y. Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol. 1998;139:454–60.CrossRefPubMed
Metadata
Title
Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome
Authors
Cécile Delecroix
Raja Brauner
Jean-Claude Souberbielle
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2018
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-018-0992-3

Other articles of this Issue 1/2018

BMC Pediatrics 1/2018 Go to the issue

Research article

Can clinical signs or symptoms combined with basic hematology data be used to predict the presence of bacterial infections in febrile children under - 5 years?

Research article

Maternal depression and child severe acute malnutrition: a case-control study from Kenya

Study protocol

Discovering the sense of touch: protocol for a randomised controlled trial examining the efficacy of a somatosensory discrimination intervention for children with hemiplegic cerebral palsy

Study protocol

Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project

Research article

Prevalence of attention-deficit/hyperactivity disorder symptoms and their associations with sleep schedules and sleep-related problems among preschoolers in mainland China

Research article

Motivations for weight loss in adolescents with overweight and obesity: a systematic review