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Published in: BMC Ophthalmology 1/2020

01-12-2020 | Retinal Detachment | Case report

Development and spontaneous closure of a secondary macular hole associated with submacular hemorrhage due to polypoidal choroidal vasculopathy: a case report

Authors: Minami Chino, Yuji Yoshikawa, Junji Kanno, Takamitsu Nagashima, Yu Sakaki, Takeshi Katsumoto, Masayuki Shibuya, Takuhei Shoji, Jun Makita, Kei Shinoda

Published in: BMC Ophthalmology | Issue 1/2020

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Abstract

Background

Macular hole (MH) is a retinal break in the fovea involving partial or complete dehiscence of the neural retinal layers affecting the visual quality by decreasing visual acuity (VA) and visual deformation. We describe a case of secondary MH associated with submacular hemorrhage (SMH) due to polypoidal choroidal vasculopathy (PCV), which showed spontaneous closure.

Case presentation

A 67-year-old man developed decreased VA in his right eye due to an SMH. The VA was 20/50, and monthly intravitreal injection of aflibercept was administered three times. The SMH gradually decreased, and 10 months later the external limiting membrane was found to be perforated, resulting in MH. The old clot disappeared, and the MH remained for 10 months. Twenty-three months later, serous retinal detachment (SRD) involving the macula appeared and the MH had disappeared. SRD gradually disappeared, and macular configuration recovered. VA gradually improved and became 20/20 38 months later.

Conclusion

Dynamic change of the ultrastructure in an unusual case of secondary-developed and spontaneously closed MH was clearly observed. Although the mechanism was unknown, the small diameter size and exudative PCV are thought to have contributed to the closure.
Literature
1.
go back to reference Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, et al. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013;120:2611–9.CrossRef Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, et al. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013;120:2611–9.CrossRef
2.
go back to reference Budoff G, Bhagat N, Zarbin MA. Traumatic macular hole: diagnosis, natural history, and management. J Ophthalmol. 2019;2019:5837832.PubMedPubMedCentral Budoff G, Bhagat N, Zarbin MA. Traumatic macular hole: diagnosis, natural history, and management. J Ophthalmol. 2019;2019:5837832.PubMedPubMedCentral
3.
go back to reference Lee YJ, Kim M. Macular hole formation after intravitreal injection of bevacizumab for diabetic macular edema. Korean J Ophthalmol. 2019;33:198–9.CrossRef Lee YJ, Kim M. Macular hole formation after intravitreal injection of bevacizumab for diabetic macular edema. Korean J Ophthalmol. 2019;33:198–9.CrossRef
4.
go back to reference Benzerroug M, Genevois O, Siahmed K, Nasser Z, Muraine M, Brasseur G. Results of surgery on macular holes that develop after rhegmatogenous retinal detachment. Br J Ophthalmol. 2008;92:217–9.CrossRef Benzerroug M, Genevois O, Siahmed K, Nasser Z, Muraine M, Brasseur G. Results of surgery on macular holes that develop after rhegmatogenous retinal detachment. Br J Ophthalmol. 2008;92:217–9.CrossRef
5.
go back to reference Cho JH, Park SE, Han JR, Kim HK, Nam WH. Macular hole after intravitreal ranibizumab injection for polypoidal choroidal vasculopathy. Clin Exp Optom. 2011;94:586–8.CrossRef Cho JH, Park SE, Han JR, Kim HK, Nam WH. Macular hole after intravitreal ranibizumab injection for polypoidal choroidal vasculopathy. Clin Exp Optom. 2011;94:586–8.CrossRef
6.
go back to reference Querques G, Souied EH, Soubrane G. Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration. Acta Ophthalmol. 2009;87:235–7.CrossRef Querques G, Souied EH, Soubrane G. Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration. Acta Ophthalmol. 2009;87:235–7.CrossRef
7.
go back to reference Su D, Klufas MA, Hubschman JP. Spontaneous closure of a full-thickness macular hole with conversion to exudative age-related macular degeneration. JAMA Ophthalmol. 2016;134:604–6.CrossRef Su D, Klufas MA, Hubschman JP. Spontaneous closure of a full-thickness macular hole with conversion to exudative age-related macular degeneration. JAMA Ophthalmol. 2016;134:604–6.CrossRef
8.
go back to reference Bakri SJ, Sears JE, Lewis H. Management of macular hole and submacular hemorrhage in the same eye. Graefes Arch Clin Exp Ophthalmol. 2007;245:609–11.CrossRef Bakri SJ, Sears JE, Lewis H. Management of macular hole and submacular hemorrhage in the same eye. Graefes Arch Clin Exp Ophthalmol. 2007;245:609–11.CrossRef
9.
go back to reference Kawaji T, Takasu I, Takano A, Sato T, Hashida M. Internal limiting membrane peeling-repositioning technique for macular hole after macular hemorrhage associated with rupture of retinal arterial macroaneurysm. Retina. 2019;39:S84–6.CrossRef Kawaji T, Takasu I, Takano A, Sato T, Hashida M. Internal limiting membrane peeling-repositioning technique for macular hole after macular hemorrhage associated with rupture of retinal arterial macroaneurysm. Retina. 2019;39:S84–6.CrossRef
10.
go back to reference Uemoto R, Mizuki N. Spontaneous closure of a macular hole caused by a ruptured retinal arterial macroaneurysm. Eur J Ophthalmol. 2008;18:462–5.CrossRef Uemoto R, Mizuki N. Spontaneous closure of a macular hole caused by a ruptured retinal arterial macroaneurysm. Eur J Ophthalmol. 2008;18:462–5.CrossRef
11.
go back to reference Lee J, Nguyen VQ, Doss MK, Eller AW. Spontaneous closure of a chronic full thickness macular hole after failed surgery. Am J Ophthalmol Case Rep. 2019;13:59–61.CrossRef Lee J, Nguyen VQ, Doss MK, Eller AW. Spontaneous closure of a chronic full thickness macular hole after failed surgery. Am J Ophthalmol Case Rep. 2019;13:59–61.CrossRef
12.
go back to reference Hamano R, Shimoda Y, Kishi S. Tomographic features of spontaneous closure of full-thickness macular holes. Jpn J Ophthalmol. 2007;51:76–7.CrossRef Hamano R, Shimoda Y, Kishi S. Tomographic features of spontaneous closure of full-thickness macular holes. Jpn J Ophthalmol. 2007;51:76–7.CrossRef
13.
go back to reference Hayashi I, Shinoda H, Nagai N, Tsubota K, Ozawa Y. Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: a case report. Medicine. 2019;98:e14230.CrossRef Hayashi I, Shinoda H, Nagai N, Tsubota K, Ozawa Y. Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: a case report. Medicine. 2019;98:e14230.CrossRef
14.
go back to reference Kawano K, Ito Y, Kondo M, Ishikawa K, Kachi S, Ueno S, et al. Displacement of foveal area toward optic disc after macular hole surgery with internal limiting membrane peeling. Eye. 2013;27:871–7.CrossRef Kawano K, Ito Y, Kondo M, Ishikawa K, Kachi S, Ueno S, et al. Displacement of foveal area toward optic disc after macular hole surgery with internal limiting membrane peeling. Eye. 2013;27:871–7.CrossRef
15.
go back to reference Yamashita T, Uemara A, Uchino E, Doi N, Ohba N. Spontaneous closure of traumatic macular hole. Am J Ophthalmol. 2002;133:230–5.CrossRef Yamashita T, Uemara A, Uchino E, Doi N, Ohba N. Spontaneous closure of traumatic macular hole. Am J Ophthalmol. 2002;133:230–5.CrossRef
16.
go back to reference Liang X, Liu W. Characteristics and risk factors for spontaneous closure of idiopathic full-thickness macular hole. J Ophthalmol. 2019;2019:4793764.CrossRef Liang X, Liu W. Characteristics and risk factors for spontaneous closure of idiopathic full-thickness macular hole. J Ophthalmol. 2019;2019:4793764.CrossRef
17.
go back to reference Sagara N, Kawaji T, Koshiyama Y, Inomata Y, Fukushima M, Tanihara H. Macular hole formation after macular haemorrhage associated with rupture of retinal arterial macroaneurysm. Br J Ophthalmol. 2009;93:1337–40.CrossRef Sagara N, Kawaji T, Koshiyama Y, Inomata Y, Fukushima M, Tanihara H. Macular hole formation after macular haemorrhage associated with rupture of retinal arterial macroaneurysm. Br J Ophthalmol. 2009;93:1337–40.CrossRef
18.
go back to reference Sato R, Yasukawa T, Hirano Y, Ogura Y. Early-onset macular holes following ruptured retinal arterial macroaneurysms. Graefes Arch Clin Exp Ophthalmol. 2008;246:1779–82.CrossRef Sato R, Yasukawa T, Hirano Y, Ogura Y. Early-onset macular holes following ruptured retinal arterial macroaneurysms. Graefes Arch Clin Exp Ophthalmol. 2008;246:1779–82.CrossRef
19.
go back to reference Tashimo A, Mitamura Y, Ohtsuka K, Okushiba U, Imaizumi H, Takeda M. Macular hole formation following ruptured retinal arterial macroaneurysm. Am J Ophthalmol. 2003;135(4):487–92.CrossRef Tashimo A, Mitamura Y, Ohtsuka K, Okushiba U, Imaizumi H, Takeda M. Macular hole formation following ruptured retinal arterial macroaneurysm. Am J Ophthalmol. 2003;135(4):487–92.CrossRef
20.
go back to reference Toth CA, Morse LS, Hjelmeland LM, Landers MB. Fibrin directs early retinal damage after experimental subretinal hemorrhage. Arch Ophthalmol. 1991;109:723–9.CrossRef Toth CA, Morse LS, Hjelmeland LM, Landers MB. Fibrin directs early retinal damage after experimental subretinal hemorrhage. Arch Ophthalmol. 1991;109:723–9.CrossRef
21.
go back to reference Lewis H, Resnick SC, Flannery JG, Straatsma BR. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Am J Ophthalmol. 1991;111:197–204.CrossRef Lewis H, Resnick SC, Flannery JG, Straatsma BR. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Am J Ophthalmol. 1991;111:197–204.CrossRef
22.
go back to reference McCabe CM, Flynn HW, McLean WC, Brod RD, McDonald HR, Johnson MW, et al. Nonsurgical management of macular hemorrhage secondary to retinal artery macroaneurysms. Arch Ophthalmol. 2000;118:780–5.CrossRef McCabe CM, Flynn HW, McLean WC, Brod RD, McDonald HR, Johnson MW, et al. Nonsurgical management of macular hemorrhage secondary to retinal artery macroaneurysms. Arch Ophthalmol. 2000;118:780–5.CrossRef
23.
go back to reference Carvounis PE, Kopel AC, Benz MS. Retinal pigment epithelium tears following ranibizumab for exudative age-related macular degeneration. Am J Ophthalmol. 2007;143:504–5.CrossRef Carvounis PE, Kopel AC, Benz MS. Retinal pigment epithelium tears following ranibizumab for exudative age-related macular degeneration. Am J Ophthalmol. 2007;143:504–5.CrossRef
24.
go back to reference Chen H, Chen W, Zheng K, Peng K, Xia H, Zhu L. Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography. Sci Rep. 2015;5:12343.CrossRef Chen H, Chen W, Zheng K, Peng K, Xia H, Zhu L. Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography. Sci Rep. 2015;5:12343.CrossRef
25.
go back to reference Oliver A, Wojcik EJ. Macular detachment for treatment of persistent macular hole. Ophthalmic Surg Lasers Imaging. 2011;42:516–8.CrossRef Oliver A, Wojcik EJ. Macular detachment for treatment of persistent macular hole. Ophthalmic Surg Lasers Imaging. 2011;42:516–8.CrossRef
26.
go back to reference Wong R, Howard C, Orobona GD. Retina expansion technique for macular hole apposition report 2: efficacy, closure rate, and risks of a macular detachment technique to close large full-thickness macular holes. Retina. 2018;38:660–3.CrossRef Wong R, Howard C, Orobona GD. Retina expansion technique for macular hole apposition report 2: efficacy, closure rate, and risks of a macular detachment technique to close large full-thickness macular holes. Retina. 2018;38:660–3.CrossRef
Metadata
Title
Development and spontaneous closure of a secondary macular hole associated with submacular hemorrhage due to polypoidal choroidal vasculopathy: a case report
Authors
Minami Chino
Yuji Yoshikawa
Junji Kanno
Takamitsu Nagashima
Yu Sakaki
Takeshi Katsumoto
Masayuki Shibuya
Takuhei Shoji
Jun Makita
Kei Shinoda
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2020
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-020-01370-8

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