Top

BMC Ophthalmology

Published in:

Open Access 01-12-2020 | IgA Vasculitis | Case report

Effect of intraocular anti-VEGF on cystoid macular edema associated with Henoch-Schonlein purpura-a case report

Authors: Dongyan Pan, Xiao Cui, Weiye Zhu, Haifeng Qin, Qing Li, Bing Xu, Jin-hui Wu

Published in: BMC Ophthalmology | Issue 1/2020

Abstract

Background

To report a bilateral cystoid macular edema associated with Henoch-Schonleinpurpura.

Case presentation

A 21-year-old man presented a bilateral, painless, and bilateral blurred vision for 5 weeks with visual acuity (VA) of 6/12 on the right eye and 6/48 on the left. FA and OCT showed bilateral cystoid macular edema, and the fundus photograph showed retinal hemorrhages. Using intravenous dexamethasone could reduce macular edema, but it reoccurred shortly after switching to oral prednisone. Repeated intraocular injection of anti-VEGF in both eyes was performed and VA improved to 6/6 on the right eye and 6/7.5 on the left with the regression of edema after 6 months follow-up.

Conclusions

Intraocular anti-VEGF might be an alternative choice to glucocorticoid in cases of bilateral cystoid macular edema associated with Henoch-Schonlein purpura.

Yamabe H, Ozawa K, Fukushi K, Kubota H, Ohsawa H, Akitsu H, Chiba N, Seino S, Miyata M, Onodera K, et al. IgA nephropathy and Henoch-Schonlein purpura nephritis with anterior uveitis. Nephron. 1988;50(4):368–70.CrossRefPubMed

Muqit MM, Gallagher MJ, Gavin M, Roberts F, Jardine AG. Henoch-Schonlein purpura with keratitis and granulomatous anterior uveitis. Br J Ophthalmol. 2005;89(9):1221–2.CrossRefPubMedPubMedCentral

Chuah J, Meaney T. Anterior ischaemic optic neuropathy secondary to Henoch-Schonlein Purpura. Eye. 2005;19(9):1028.CrossRefPubMed

Wu TT, Sheu SJ, Chou LC, Wu TT, Sheu SJ, Sheu SJ. Henoch-Schonlein purpura with bilateral central retinal artery occlusion. Br J Ophthalmol. 2002;86(3):351–2.CrossRefPubMedPubMedCentral

Ma'luf RN, Zein WM, El Dairi MA, Bashshur ZF. Bilateral subperiosteal orbital hematomas and Henoch-Schonlein purpura. Arch Ophthalmol. 2002;120(10):1398–9.PubMed

Nicholson L, Mathews D. Bilateral cystoid macular oedema and cotton wool spots associated with Henoch-Schonlein purpura. BMJ Case Rep. 2013. https://doi.org/10.1136/bcr-2013-200159.

Patheja RS, Chidgey A. A rare case of bilateral cystoid macular oedema associated with decompensated Henoch-Schonlein purpura-related nephropathy. Clin Exp Ophthalmol. 2016;44(3):209–12.CrossRefPubMed

Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol. 2006;39(5):469–78.PubMed

Park SJ, Shin JI. Role of interleukin-6 and vascular endothelial growth factor in Henoch-Schonlein purpura with posterior reversible encephalopathy syndrome. Pediatr Neurol. 2012;47(5):386.CrossRefPubMed

10.

Zeng XQ, Xu ZC, Dang XQ, He XJ, Yi ZW. Expression of vascular endothelial growth factor is related to microvessel injury of renal interstitium in children with Henoch Schonlein purpura nephritis. Zhongguo dang dai er ke za zhi. 2009;11(9):717–21.PubMed

11.

Topaloglu R, Sungur A, Baskin E, Besbas N, Saatci U, Bakkaloglu A. Vascular endothelial growth factor in Henoch-Schonlein purpura. J Rheumatol. 2001;28(10):2269–73.PubMed

12.

Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, et al. Association between retinal hemorrhagic patterns and perfusion status in eyes with acute central retinal vein occlusion. Retina. 2017;37(3):500–8.CrossRefPubMed

Title: Effect of intraocular anti-VEGF on cystoid macular edema associated with Henoch-Schonlein purpura-a case report
Authors: Dongyan Pan
Xiao Cui
Weiye Zhu
Haifeng Qin
Qing Li
Bing Xu
Jin-hui Wu
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: IgA Vasculitis
IgA Vasculitis
Glucocorticoid
Edema
Published in: BMC Ophthalmology / Issue 1/2020
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-020-01351-x

At a glance: The STEP trials

Springer Medicine

Effect of intraocular anti-VEGF on cystoid macular edema associated with Henoch-Schonlein purpura-a case report

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2020

Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract patients

Knowledge of glaucoma and associated factors among adults in Gish Abay town, Northwest Ethiopia

Sub-perfluoro-n-octane injection of ocular viscoelastic device assisted inverted internal limiting membrane flap for macular hole retinal detachment surgery: a novel technique

Cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (the BICAT-NL study): study design of a prospective multicenter randomised controlled trial

A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation

Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial