Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2018

Open Access 01-12-2018 | Research article

Single-step Transepithelial photorefractive keratectomy in the treatment of mild, moderate, and high myopia: six month results

Authors: Lei Xi, Chen Zhang, Yanling He

Published in: BMC Ophthalmology | Issue 1/2018

Login to get access

Abstract

Background

To evaluate the safety, efficacy, and the refractive outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) for the correction of mild, moderate, and high myopia.

Methods

This study consecutively recruited 32 high myopic eyes, 32 mild myopic and 32 moderate myopic eyes. Eyes with myopia that had undergone TransPRK treatment. Pre- and post-operative visual and refractive data, corneal Higher Order Aberration (HOA) as well as safety and efficacy indices were analyzed at 6 months postoperatively.

Results

Six months after TransPRK, the manifest refraction spherical equivalent (SE) was not significantly between high myopia group and moderate myopia group (p = 0.636). No eyes lost ≥2 lines of corrected distant visual acuity (CDVA) in high myopic eyes. The uncorrected distance visual acuity (UDVA) was significantly higher in low and moderate myopia groups than the high myopia group (P < 0.001; P = 0.002). The CDVA was not significantly different between moderate and high myopia groups (P = 0.057). There was no significant difference in mean safety index between high myopia group (1.01 ± 0.14) and mild myopia group (1.08 ± 0.15) (P > 0.05). The mean safety index was significantly higher in the moderate myopia group (1.16 ± 0.23) than in the high myopia group (1.01 ± 0.14) (P = 0.002). The efficacy index was significantly higher in the moderate myopia group (1.05 ± 0.20) than in the high myopia group (0.89 ± 0.17) (P = 0.02), and there was no significant difference between the high myopia group (0.89 ± 0.17) and the low myopia group (0.96 ± 0.16) (P = 0.14).

Conclusions

The mean safety index was over 1.0 in the three groups. TransPRK showed acceptable safety and efficacy in the moderate myopic eyes, as well as mild and high myopic eyes. High myopic eyes got very similar refractive results with moderate myopic eyes six months postoperatively. The safety and efficacy indexes were not significantly different between the high myopia group and the low myopia group.
Literature
1.
Fadlallah A, Fahed D, Khalil K, Dunia I, Menassa J, El Rami H, et al. Transepithelial photorefractive keratectomy: clinical results. J Cataract Refract Surg. 2011;37(10):1852–7.CrossRefPubMed
2.
Wu W, Wang Y. The Correlation Analysis between Corneal Biomechanical. Properties and the Surgically Induced Corneal High-Order Aberrations after Small Incision Lenticule Extraction and Femtosecond Laser In Situ Keratomileusis. J Ophthalmol. 2015;2015:758196.PubMedPubMedCentral
3.
Antonios R, Abdul Fattah M, Arba Mosquera S, Abiad BH, Sleiman K, Awwad ST. Single-step transepithelial versus alcohol-assisted photorefractive keratectomy in the treatment of high myopia: a comparative evaluation over 12 months. Br J Ophthalmol. 2017;101(8):1106–12.
4.
Adib-Moghaddam S, Soleyman-Jahi S, Salmanian B, Omidvari AH, Adili-Aghdam F, Noorizadeh F, et al. Single-step transepithelial photorefractive keratectomy in myopia and astigmatism: 18-month follow-up. J Cataract Refract Surg. 2016;42(11):1570–8.CrossRefPubMed
5.
Kaluzny BJ, Cieslinska I, Mosquera SA, Verma S. Single-step Transepithelial PRK vs alcohol-assisted PRK in myopia and compound myopic astigmatism correction. Medicine (Baltimore). 2016;95(6):e1993.CrossRef
6.
Luger MH, Ewering T, Arba-Mosquera S. Consecutive myopia correction with transepithelial versus alcohol-assisted photorefractive keratectomy in contralateral eyes: one-year results. J Cataract Refract Surg. 2012 Aug;38(8):1414–23.CrossRefPubMed
7.
Luger MH, Ewering T, Arba-Mosquera S. Myopia correction with transepithelial photorefractive keratectomy versus femtosecondLassisted laser in situ keratomileusis: one-year case-matched analysis. J Cataract Refract Surg. 2016;42(11):1579–87.CrossRefPubMed
8.
Aslanides IM, Kymionis GD. Trans advanced surface laser ablation (TransPRK) outcomes using SmartPulse technology. Cont Lens Anterior Eye. 2017;40(1):42–6.CrossRefPubMed
9.
Li L, Cheng GPM, Ng ALK, Chan TCY, Jhanji V, Wang Y. Influence of Refractive Status on the Higher-Order Aberration Pattern After Small Incision Lenticule Extraction Surgery. Cornea. 2017 Aug;36(8):967–72.CrossRefPubMed
10.
Stojanovic A, Chen S, Chen X, Stojanovic F, Zhang J, Zhang T, et al. One-Step Transepithelial Topography-Guided Ablation in the Treatment of Myopic Astigmatism. PLoS One. 2013;8(6):e66618.CrossRefPubMedPubMedCentral
11.
Naderi M, Jadidi K, Mosavi SA, Daneshi SA. Transepithelial Photorefractive Keratectomy for Low to Moderate Myopia in Comparison with Conventional Photorefractive Keratectomy. J Ophthalmic Vis Res. 2016;11(4):358–62.CrossRefPubMedPubMedCentral
12.
Yildirim Y, Olcucu O, Alagoz N, Agca A, Karakucuk Y, Demirok A. Comparison of visual and refractive results after transepithelial and mechanical photorefractive keratectomy in myopia. Int Ophthalmol. 2018;38(2):627–33.
13.
Aslanides IM, Georgoudis PN, Selimis VD, Mukherjee AN. Single-step transepithelial ASLA (SCHWIND) with mitomycin-C for the correction of high myopia: long term follow-up. Clin Ophthalmol. 2014;9:33–41.CrossRefPubMedPubMedCentral
14.
Torky MA, Alzafiri YA. Visual and refractive outcomes of small-incision lenticule extraction in mild, moderate, and high myopia: six- month results. J Cataract Refract Surg. 2017;43(4):459–65.CrossRefPubMed
15.
Chan TC, Yu MC, Ng A, Wang Z, Cheng GP, Jhanji V. Early outcomes after small incision lenticule extraction and photorefractive keratectomy for correction of high myopia. Sci Rep. 2016;6:32820.CrossRefPubMedPubMedCentral
16.
Serrao S, Lombardo G, Ducoli P, Lombardo M. Long-term corneal wavefront aberration variations after photorefractive keratectomy for myopia and myopic astigmatism. J Cataract Refract Surg. 2011;37(9):1655–66.CrossRefPubMed
17.
Ikeda T, Shimizu K, Igarashi A, Kasahara S, Kamiya K. Twelve-year follow-up of lase in situ Keratomileusis for moderate to high myopia. Biomed Res Int. 2017;2017:9391436.CrossRefPubMedPubMedCentral
18.
Jin HY, Wan T, Wu F, Yao K. Comparison of visual results and higher-order aberrations after small incision lenticule extraction (SMILE): high myopia vs. mild to moderate myopia. BMC Ophthalmol. 2017;17(1):118.CrossRefPubMedPubMedCentral
19.
Yamane N, Miyata K, Samejima T, Hiraoka T, Kiuchi T, Okamoto F, et al. Ocular higher-order aberrations and contrast sensitibity after conventional laser in situ keratomileusis. Invest Ophthalmol Vis Sci. 2004s;45(11):3986–90.CrossRefPubMed
20.
Moshirfar M, Schliesser JA, Chang JC, Oberg TJ, Mifflin MD, Townley R, et al. Visual outcomes after wavefront-guided photorefractive keratectomy and wavefront-guided laser in situ keratomileusis prospective comparison. J Cataract Refract Surg. 2010;36(8):1336–43.CrossRefPubMed
21.
He JC, Sun P, Held R, Thorn F, Sun X, Gwiazda JE. Wavefront aberrations in eyes of emmetropic and moderately myopic school children and young adults. Vis Res. 2002;42(8):1063–70.CrossRefPubMed
Metadata
Title
Single-step Transepithelial photorefractive keratectomy in the treatment of mild, moderate, and high myopia: six month results
Authors
Lei Xi
Chen Zhang
Yanling He
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-018-0888-x

Other articles of this Issue 1/2018

BMC Ophthalmology 1/2018 Go to the issue

Research article

Evidence for alterations in fixational eye movements in glaucoma

Research article

Prevalence and clinical characteristics of dry eye disease in community-based type 2 diabetic patients: the Beixinjing eye study

Case report

A case of silicone oil adhered to the retinal surface via perfluorocarbon liquid

Correction

Correction to: Risk factors of presenile nuclear cataract in health screening study

Case report

The follow-up observation on the therapeutic effect of photodynamic therapy for the juxtapapillary retinal capillary hemangioma: a case report

Case report

Doyne honeycomb retinal dystrophy/malattia leventinese induced by EFEMP1 mutation in a Chinese family