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Published in: BMC Ophthalmology 1/2018

Open Access 01-12-2018 | Research article

Conjunctival repair after glaucoma drainage device exposure using collagen-glycosaminoglycane matrices

Authors: André Rosentreter, Alexandra Lappas, Randolf Alexander Widder, Maged Alnawaiseh, Thomas Stefan Dietlein

Published in: BMC Ophthalmology | Issue 1/2018

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Abstract

Background

To report the results of the repair of conjunctival erosions resulting from glaucoma drainage device surgery using collagen-glycosaminoglycane matrices (CGM).

Methods

Case series of 8 patients who underwent revision surgery due to conjunctival defects with exposed tubes through necrosis of the overlying scleral flap and conjunctiva after Baerveldt drainage device surgery. The defects were repaired by lateral displacement of the tube towards the sclera, with a slice of a CGM as a patch, covered by adjacent conjunctiva.

Result

Successful, lasting closure (follow-up of 12 to 42 months) of the conjunctival defects was achieved without any side-effects or complications in all eight cases.

Conclusions

Erosion of the drainage tube, creating buttonholes in the conjunctiva after implantation of glaucoma drainage devices, is a potentially serious problem. It can be managed successfully using a biodegradable CGM as a patch.
Literature
1.
go back to reference Ayyala RS, Zurakowski D, Smith JA, Monshizadeh R, Netland PA, Richards DW, et al. A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology. 1998;105:1968–76.CrossRefPubMed Ayyala RS, Zurakowski D, Smith JA, Monshizadeh R, Netland PA, Richards DW, et al. A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology. 1998;105:1968–76.CrossRefPubMed
3.
go back to reference Aslanides IM, Spaeth GL, Schmidt CM, Lanzl IM, Gandham SB. Autologous patch graft in tube shunt surgery. J Glaucoma. 1999;8:306–9.CrossRefPubMed Aslanides IM, Spaeth GL, Schmidt CM, Lanzl IM, Gandham SB. Autologous patch graft in tube shunt surgery. J Glaucoma. 1999;8:306–9.CrossRefPubMed
4.
go back to reference Siegner SW, Netland PA, Urban RC Jr, Williams AS, Richards DW, Latina MA, et al. Clinical experience with the Baerveldt glaucoma drainage implant. Ophthalmology. 1995;102:1298–307.CrossRefPubMed Siegner SW, Netland PA, Urban RC Jr, Williams AS, Richards DW, Latina MA, et al. Clinical experience with the Baerveldt glaucoma drainage implant. Ophthalmology. 1995;102:1298–307.CrossRefPubMed
6.
go back to reference DeBry PW, Perkins TW, Heatley G, Kaufman P, Brumback LC. Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Arch Ophthalmol. 2002;120:297–300.CrossRefPubMed DeBry PW, Perkins TW, Heatley G, Kaufman P, Brumback LC. Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin. Arch Ophthalmol. 2002;120:297–300.CrossRefPubMed
7.
go back to reference Francis BA, DiLoreto DA Jr, Chong LP, Rao N. Late-onset bacteria endophthalmitis following glaucoma drainage implantation. Ophthalmic Surg Lasers Imaging. 2003;34:128–30. Francis BA, DiLoreto DA Jr, Chong LP, Rao N. Late-onset bacteria endophthalmitis following glaucoma drainage implantation. Ophthalmic Surg Lasers Imaging. 2003;34:128–30.
8.
go back to reference Rosentreter A, Schild AM, Dinslage S, Dietlein TS. Biodegradable implant for tissue repair after glaucoma drainage device surgery. J Glaucoma. 2012;21:76–8.PubMed Rosentreter A, Schild AM, Dinslage S, Dietlein TS. Biodegradable implant for tissue repair after glaucoma drainage device surgery. J Glaucoma. 2012;21:76–8.PubMed
9.
go back to reference Stenzel KH, Miyata T, Rubin AL. Collagen as a biomaterial. Annu Rev Biophys Bioeng. 1974;3:231–53.CrossRefPubMed Stenzel KH, Miyata T, Rubin AL. Collagen as a biomaterial. Annu Rev Biophys Bioeng. 1974;3:231–53.CrossRefPubMed
10.
go back to reference Jacobi PC, Krieglstein GK. Trabecular aspiration. A new mode to treat pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 1995;36:2270–6.PubMed Jacobi PC, Krieglstein GK. Trabecular aspiration. A new mode to treat pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 1995;36:2270–6.PubMed
11.
go back to reference Goulet RJ 3rd, Phan AD, Cantor LB, WuDunn D. Efficacy of the Ahmed S2 glaucoma valve compared with the Baerveldt 250 mm2 glaucoma implant. Ophthalmology. 2008;115:1141–7.CrossRefPubMed Goulet RJ 3rd, Phan AD, Cantor LB, WuDunn D. Efficacy of the Ahmed S2 glaucoma valve compared with the Baerveldt 250 mm2 glaucoma implant. Ophthalmology. 2008;115:1141–7.CrossRefPubMed
12.
go back to reference Syed HM, Law SK, Nam SH, Li G, Caprioli J, Coleman A. Baerveldt-350 implant versus Ahmed valve for refractory glaucoma. A case-controlled comparison. J Glaucoma. 2004;13:38–45.CrossRefPubMed Syed HM, Law SK, Nam SH, Li G, Caprioli J, Coleman A. Baerveldt-350 implant versus Ahmed valve for refractory glaucoma. A case-controlled comparison. J Glaucoma. 2004;13:38–45.CrossRefPubMed
13.
go back to reference WuDunn D, Phan AD, Cantor LB, Lind JT, Cortes A, Wu B. Clinical experience with the Baerveldt 250 mm2 glaucoma implant. Ophthalmology. 2006;113:766–72.CrossRefPubMed WuDunn D, Phan AD, Cantor LB, Lind JT, Cortes A, Wu B. Clinical experience with the Baerveldt 250 mm2 glaucoma implant. Ophthalmology. 2006;113:766–72.CrossRefPubMed
14.
go back to reference Gedde SJ, Schiffman JC, Feuer WJ, Herndon LW, Brandt JD, Budenz DL, Tube Versus Trabeculectomy Study Group. Treatment outcomes in the tube versus trabeculectomy (TVT) study after five years of follow-up. Am J Ophthalmol. 2012;153:789–803.CrossRefPubMedPubMedCentral Gedde SJ, Schiffman JC, Feuer WJ, Herndon LW, Brandt JD, Budenz DL, Tube Versus Trabeculectomy Study Group. Treatment outcomes in the tube versus trabeculectomy (TVT) study after five years of follow-up. Am J Ophthalmol. 2012;153:789–803.CrossRefPubMedPubMedCentral
15.
go back to reference Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC, Tube Versus Trabeculectomy Study Group. Postoperative complications in the tube versus trabeculectomy (TVT) study during five years of follow-up. Am J Ophthalmol. 2012;153:804–14.CrossRefPubMedPubMedCentral Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC, Tube Versus Trabeculectomy Study Group. Postoperative complications in the tube versus trabeculectomy (TVT) study during five years of follow-up. Am J Ophthalmol. 2012;153:804–14.CrossRefPubMedPubMedCentral
17.
go back to reference Ainsworth G, Rotchford A, Dua HS, King AJ. A novel use of amniotic membrane in the management of tube exposure following glaucoma tube shunt surgery. Br J Ophthalmol. 2006;90:417–9.CrossRefPubMedPubMedCentral Ainsworth G, Rotchford A, Dua HS, King AJ. A novel use of amniotic membrane in the management of tube exposure following glaucoma tube shunt surgery. Br J Ophthalmol. 2006;90:417–9.CrossRefPubMedPubMedCentral
18.
go back to reference Chen HS, Ritch R, Krupin T, Hsu WC. Control of filtering bleb structure through tissue bioengineering: an animal model. Invest Ohthalmol Vis Sci. 2006;47:5310–4.CrossRef Chen HS, Ritch R, Krupin T, Hsu WC. Control of filtering bleb structure through tissue bioengineering: an animal model. Invest Ohthalmol Vis Sci. 2006;47:5310–4.CrossRef
19.
go back to reference Hsu WC, Ritch R, Krupin T, Chen HS. Tissue bioengineering for surgical bleb defects: an animal study. Graefes Arch Clin Exp Ophthalmol. 2008;246:709–17.CrossRefPubMed Hsu WC, Ritch R, Krupin T, Chen HS. Tissue bioengineering for surgical bleb defects: an animal study. Graefes Arch Clin Exp Ophthalmol. 2008;246:709–17.CrossRefPubMed
20.
go back to reference Hsu WC, Spilker MH, Yannas IV, Rubin PA. Inhibition of conjunctival scarring and contraction by a porous collagen-glycosaminoglycan implant. Invest Ophthalmol Vis Sci. 2000;41:2404–11.PubMed Hsu WC, Spilker MH, Yannas IV, Rubin PA. Inhibition of conjunctival scarring and contraction by a porous collagen-glycosaminoglycan implant. Invest Ophthalmol Vis Sci. 2000;41:2404–11.PubMed
21.
go back to reference Stephens JD, Sarkisian SR Jr. The use of collagen matrix (Ologen) as a patch graft in glaucoma tube shunt surgery, a retrospective chart review. F1000Res. 2016;5:1898.CrossRefPubMedPubMedCentral Stephens JD, Sarkisian SR Jr. The use of collagen matrix (Ologen) as a patch graft in glaucoma tube shunt surgery, a retrospective chart review. F1000Res. 2016;5:1898.CrossRefPubMedPubMedCentral
Metadata
Title
Conjunctival repair after glaucoma drainage device exposure using collagen-glycosaminoglycane matrices
Authors
André Rosentreter
Alexandra Lappas
Randolf Alexander Widder
Maged Alnawaiseh
Thomas Stefan Dietlein
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-018-0721-6

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