Skip to main content
Top
Published in: BMC Ophthalmology 1/2018

Open Access 01-12-2018 | Research article

Prevalence and causes of low vision and blindness in an elderly population in Nepal: the Bhaktapur retina study

Authors: Raba Thapa, Sanyam Bajimaya, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S. Thapa, G. H. M. B. van Rens

Published in: BMC Ophthalmology | Issue 1/2018

Login to get access

Abstract

Background

This study aims to explore the prevalence and causes of low vision and blindness focused on retinal disease in a population above 60 years in Nepal.

Methods

Two thousand one hundred subjects were enrolled in a population-based cross-sectional study. History, presenting and best corrected visual acuity after subjective refraction, anterior and posterior segment examinations was obtained in detail.

Results

Among the total subjects, 1860 (88.57%) had complete information. Age varies from 60 to 95 (mean age: 69.64 ± 7.31) years. Low vision and blindness in both eyes at presentation was found in 984 (52.90%, 95% confidence interval (CI): 50.60–55.19) and 36 (1.94%, 95% CI: 1.35–2.66) subjects respectively. After best correction, bilateral low vision and blindness was found in 426 (22.92%, 95% CI: 21.01–24.88), and 30 (1.61%, 95% CI: 0.10–2.30) subjects respectively. As compared to 60–69 years old, risk of visual impairment was four times higher (95% CI:3.26–5.58) in the 70–79 year olds and 14 times higher (95% CI: 9.72–19.73) in the age group 80 years and above.
Major causes of bilateral low vision were cataract (68.07%), followed by retinal disorders (28.64%), and for blindness; retinal disorders (46.66%), followed by cataract (43.33%). Illiteracy was significantly associated with visual impairment.

Conclusion

Among the elderly population, prevalence of visual impairment was high. Refractive error, cataract and retinal disorders were the major cause of low vision. Screening the population at the age 60 years and above, focused on cataract and posterior segment diseases, providing glasses and timely referral can help reduce visual impairment.
Literature
1.
go back to reference Varma R, Vaiaranant TS, Burkemper B, Wu S, Torres M, Hsu C, Choudhury F, McKean-Cowdin R. Visual impairment and blindness in adults in the United States: demographic and geographic variations from 2015-2050. JAMA Ophthalmol. 2016;134(7):802–9.CrossRefPubMedPubMedCentral Varma R, Vaiaranant TS, Burkemper B, Wu S, Torres M, Hsu C, Choudhury F, McKean-Cowdin R. Visual impairment and blindness in adults in the United States: demographic and geographic variations from 2015-2050. JAMA Ophthalmol. 2016;134(7):802–9.CrossRefPubMedPubMedCentral
2.
go back to reference Keunen JE, Verezen CA, Imhof SM, van Rens GHMB, Asselbergs MB, Limburg JJ. Increase in the demand of eye-care-services in the Netherlands 2010–2020. Ned TijdschrGeneeskd. 2011;155(41):A3461. Keunen JE, Verezen CA, Imhof SM, van Rens GHMB, Asselbergs MB, Limburg JJ. Increase in the demand of eye-care-services in the Netherlands 2010–2020. Ned TijdschrGeneeskd. 2011;155(41):A3461.
3.
go back to reference Bourne RRA, Flaxman SR, Braithwaite T, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e888–97.CrossRefPubMed Bourne RRA, Flaxman SR, Braithwaite T, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e888–97.CrossRefPubMed
4.
go back to reference Mariotti SP, Pascolini D. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96(5):614–8.CrossRefPubMed Mariotti SP, Pascolini D. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96(5):614–8.CrossRefPubMed
5.
go back to reference Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull World Health Organ. 1995;73:115–21.PubMedPubMedCentral Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull World Health Organ. 1995;73:115–21.PubMedPubMedCentral
6.
go back to reference Maberley DA, Hollands H, Chuo J, Tam G, Konkal J, Roesch M, Veselinovic A, Witzigmann M, Bassett K. The prevalence of low vision and blindness in Canada. Eye. 2006;20(3):341–6.CrossRefPubMed Maberley DA, Hollands H, Chuo J, Tam G, Konkal J, Roesch M, Veselinovic A, Witzigmann M, Bassett K. The prevalence of low vision and blindness in Canada. Eye. 2006;20(3):341–6.CrossRefPubMed
7.
go back to reference Limburg H, Barria von Bischhoffshausen F, Gomez P, Silva JC, Foster A. Review of recent surveys on blindness and visual impairment in Latin America. Br J Ophthalmol. 2008;92(3):315–9.CrossRefPubMed Limburg H, Barria von Bischhoffshausen F, Gomez P, Silva JC, Foster A. Review of recent surveys on blindness and visual impairment in Latin America. Br J Ophthalmol. 2008;92(3):315–9.CrossRefPubMed
8.
go back to reference Vijaya L, George R, Arvind H, et al. Prevalence and causes of blindness in the rural population of the Chhenai glaucoma study. Br J Ophthalmol. 2006;90:407–10.CrossRefPubMedPubMedCentral Vijaya L, George R, Arvind H, et al. Prevalence and causes of blindness in the rural population of the Chhenai glaucoma study. Br J Ophthalmol. 2006;90:407–10.CrossRefPubMedPubMedCentral
9.
go back to reference Dandona L, Dandona R, Srinivas M, et al. Blindness in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci. 2001;42:908–16.PubMed Dandona L, Dandona R, Srinivas M, et al. Blindness in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci. 2001;42:908–16.PubMed
10.
go back to reference Thulisiraj RD, Nirmalan PK, Ramakrishnan R, et al. Blindness and visual impairment in a rural south Indian population: the Aravind comprehensive eye survey. Ophthalmology. 2003;110(8):1491.CrossRef Thulisiraj RD, Nirmalan PK, Ramakrishnan R, et al. Blindness and visual impairment in a rural south Indian population: the Aravind comprehensive eye survey. Ophthalmology. 2003;110(8):1491.CrossRef
11.
go back to reference Dunzhu S, Wang FS, Courtright P, et al. Blindness and eye diseases in Tibet: findings from a randomized population based survey. Br J Ophthalmol. 2003;87:1443–8.CrossRefPubMedPubMedCentral Dunzhu S, Wang FS, Courtright P, et al. Blindness and eye diseases in Tibet: findings from a randomized population based survey. Br J Ophthalmol. 2003;87:1443–8.CrossRefPubMedPubMedCentral
12.
go back to reference Hsu WM, Cheng CY, Liu JH, Tsai SY, Chou P. Prevalence and causes of visual impairment in an elderly Chinese population in Taiwan: the Shihpai eye study. Ophthalmology. 2004;111(1):62–9.CrossRefPubMed Hsu WM, Cheng CY, Liu JH, Tsai SY, Chou P. Prevalence and causes of visual impairment in an elderly Chinese population in Taiwan: the Shihpai eye study. Ophthalmology. 2004;111(1):62–9.CrossRefPubMed
13.
go back to reference VanNewkirk MR, Weih L, McCarty CA, Taylor HR. Cause-specific Prevalence of bilateral visual impairment in Victoria, Australia: the visual impairment project. Ophthalmology. 2001;108(5):960–7.CrossRefPubMed VanNewkirk MR, Weih L, McCarty CA, Taylor HR. Cause-specific Prevalence of bilateral visual impairment in Victoria, Australia: the visual impairment project. Ophthalmology. 2001;108(5):960–7.CrossRefPubMed
14.
go back to reference Maberley DA, Hollands H, Chanq A, Adilman S, Chakraborti B, Kliever G. The prevalence of low vision and blindness in a Canadian inner city. Eye. 2007;21(4):528–33.CrossRefPubMed Maberley DA, Hollands H, Chanq A, Adilman S, Chakraborti B, Kliever G. The prevalence of low vision and blindness in a Canadian inner city. Eye. 2007;21(4):528–33.CrossRefPubMed
15.
go back to reference Salomao SR, Cinoto RW, Berezovsky A, Araujo-Filho A, Mitsuhiro MR, Mendieta L, Morales PH, Pokharel GP, Belfort R Jr, Ellwein LB. Prevalence and causes of vision impairment and blindness in older adults in Brazil: the Sao Paulo eye study. Ophthalmic Epidemiol. 2008;15(3):167–75.CrossRefPubMed Salomao SR, Cinoto RW, Berezovsky A, Araujo-Filho A, Mitsuhiro MR, Mendieta L, Morales PH, Pokharel GP, Belfort R Jr, Ellwein LB. Prevalence and causes of vision impairment and blindness in older adults in Brazil: the Sao Paulo eye study. Ophthalmic Epidemiol. 2008;15(3):167–75.CrossRefPubMed
16.
go back to reference Li J, Zhong H, Cai N, Luo T, Li J, Su X, Li X, Qiu X, Yang Y, Yuan Y, Yu M. The prevalence and causes of visual impairment in an elderly Chinese Bai ethnic rural population: the Yunnan minority eye study. Invest Ophthalmol Vis Sci. 2012;53(8):4498–504.CrossRefPubMed Li J, Zhong H, Cai N, Luo T, Li J, Su X, Li X, Qiu X, Yang Y, Yuan Y, Yu M. The prevalence and causes of visual impairment in an elderly Chinese Bai ethnic rural population: the Yunnan minority eye study. Invest Ophthalmol Vis Sci. 2012;53(8):4498–504.CrossRefPubMed
17.
go back to reference Cedrone C, Culasso F, Cesareo M, Nucci C, Palma S, Mancino R, Cerulli L. Incidence of blindness and low vision in a sample population: the Priverno eye study, Italy. Ophthalmology. 2003;110(3):584–8.CrossRefPubMed Cedrone C, Culasso F, Cesareo M, Nucci C, Palma S, Mancino R, Cerulli L. Incidence of blindness and low vision in a sample population: the Priverno eye study, Italy. Ophthalmology. 2003;110(3):584–8.CrossRefPubMed
18.
go back to reference AI-Merjan JI, Pandova MG, Al-Ghanim M, Al-Wayel A, Al-Mutairi S. Registered blindness and low vision in Kuwait. Ophthalmic Epidemiol. 2005;12(4):251–7.CrossRef AI-Merjan JI, Pandova MG, Al-Ghanim M, Al-Wayel A, Al-Mutairi S. Registered blindness and low vision in Kuwait. Ophthalmic Epidemiol. 2005;12(4):251–7.CrossRef
19.
go back to reference Tang Y, Wang X, Wang J, Huang W, Gao Y, Luo Y, Lu Y. Prevalence and causes of visual impairment in a Chinese adult population: the Taizhou eye study. Ophthalmology. 2015;122(7):1480–8.CrossRefPubMed Tang Y, Wang X, Wang J, Huang W, Gao Y, Luo Y, Lu Y. Prevalence and causes of visual impairment in a Chinese adult population: the Taizhou eye study. Ophthalmology. 2015;122(7):1480–8.CrossRefPubMed
20.
go back to reference Thapa SS, Berg RVD, Khanal S, et al. Prevalence of visual impairment, cataract surgery and awareness of cataract and glaucoma in Bhaktapur district of Nepal: the Bhaktapur glaucoma study. BMC Ophthalmol. 2011;11:2.CrossRefPubMedPubMedCentral Thapa SS, Berg RVD, Khanal S, et al. Prevalence of visual impairment, cataract surgery and awareness of cataract and glaucoma in Bhaktapur district of Nepal: the Bhaktapur glaucoma study. BMC Ophthalmol. 2011;11:2.CrossRefPubMedPubMedCentral
21.
go back to reference Rupert BRA, Gretchen SA, Richard WA, et al. Causes of vision loss worldwide, 1990–2010: a systematic Analysis. Lancet Glob Health. 2013;1:e 339–49.CrossRef Rupert BRA, Gretchen SA, Richard WA, et al. Causes of vision loss worldwide, 1990–2010: a systematic Analysis. Lancet Glob Health. 2013;1:e 339–49.CrossRef
22.
go back to reference Brilliant LB, Pokhrel RP, Grasset NC, Lepkowski JM, Kolstad A, Hawks W, Pararajasegaram SR, Brilliant GE, Gilbert S, Shrestha SR, Kuo J. Epidemiology of blindness in Nepal. Bull World Health Organ. 1985;63(2):375–86.PubMedPubMedCentral Brilliant LB, Pokhrel RP, Grasset NC, Lepkowski JM, Kolstad A, Hawks W, Pararajasegaram SR, Brilliant GE, Gilbert S, Shrestha SR, Kuo J. Epidemiology of blindness in Nepal. Bull World Health Organ. 1985;63(2):375–86.PubMedPubMedCentral
23.
go back to reference Sapkota YD, Pokharel GP, Nirmalan PK, Dulal S, Maharjan IM, Prakash K. Prevalence of blindness and cataract surgery in Gandaki zone, Nepal. Br J Ophthalmol. 2006;90:411–6.CrossRefPubMedPubMedCentral Sapkota YD, Pokharel GP, Nirmalan PK, Dulal S, Maharjan IM, Prakash K. Prevalence of blindness and cataract surgery in Gandaki zone, Nepal. Br J Ophthalmol. 2006;90:411–6.CrossRefPubMedPubMedCentral
24.
25.
go back to reference Rapid Assessment of Avoidable Blindness Survey. The Epidemiology of Blindness in Nepal. Nepal Netra Jyoti Sangh 2012;72. Rapid Assessment of Avoidable Blindness Survey. The Epidemiology of Blindness in Nepal. Nepal Netra Jyoti Sangh 2012;72.
27.
go back to reference Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa S, van Rens GHMB. Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2017;17:162.CrossRefPubMedPubMedCentral Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa S, van Rens GHMB. Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2017;17:162.CrossRefPubMedPubMedCentral
28.
go back to reference Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa S, van Rens GHMB. Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur retina study. Clin Ophthalmol. 2017;11:963–72.CrossRefPubMedPubMedCentral Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa S, van Rens GHMB. Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur retina study. Clin Ophthalmol. 2017;11:963–72.CrossRefPubMedPubMedCentral
29.
go back to reference ThapaSS RPP, Twyana SN, Shrestha MK, Paudel I, Paudyal G, Gurung R, Ruit S, Hewitt AW, Craiq JE, van Rens GHMB. Rational, methods and baseline demographics of the Bhaktapur glaucoma study. Clin Exp Ophthalmol. 2011;39:126–34.CrossRef ThapaSS RPP, Twyana SN, Shrestha MK, Paudel I, Paudyal G, Gurung R, Ruit S, Hewitt AW, Craiq JE, van Rens GHMB. Rational, methods and baseline demographics of the Bhaktapur glaucoma study. Clin Exp Ophthalmol. 2011;39:126–34.CrossRef
30.
go back to reference World Health Organization. International Statistical Classification of Diseases and Related Health Problems. 10th revision edition. Geneva:WHO, 1992. World Health Organization. International Statistical Classification of Diseases and Related Health Problems. 10th revision edition. Geneva:WHO, 1992.
32.
go back to reference Chylack LT, Wolfe JK, Singer DM, et al. The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol. 1993;111:831–6.CrossRefPubMed Chylack LT, Wolfe JK, Singer DM, et al. The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol. 1993;111:831–6.CrossRefPubMed
33.
go back to reference Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy: ETDRS report 9. Ophthalmology. 1981;98:766–85. Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy: ETDRS report 9. Ophthalmology. 1981;98:766–85.
34.
go back to reference International ARM Epidemiological Study Group. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367–74.CrossRef International ARM Epidemiological Study Group. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367–74.CrossRef
35.
36.
go back to reference Abdull MM, Sivasubramaniam S, Murthy GVS, et al. Causes of blindness and visual impairment in Nigeria. The Nigeria National Blindness and visual impairment survey. Invest Ophthalmol Vis Sci. 2009;50(9):4114–20.CrossRefPubMed Abdull MM, Sivasubramaniam S, Murthy GVS, et al. Causes of blindness and visual impairment in Nigeria. The Nigeria National Blindness and visual impairment survey. Invest Ophthalmol Vis Sci. 2009;50(9):4114–20.CrossRefPubMed
37.
go back to reference Report of World Health Organization/International diabetes federation consultation. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. World health Organization. 2006:1–50. Report of World Health Organization/International diabetes federation consultation. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. World health Organization. 2006:1–50.
38.
go back to reference Kandel RP, Sapkota YD, Sherchan A, et al. Cataract surgical outcome and predictors of outcomein Lumbini zone and Chitwan District of Nepal. Ophthalmic Epidemiol. 2010;17:276–81.CrossRefPubMed Kandel RP, Sapkota YD, Sherchan A, et al. Cataract surgical outcome and predictors of outcomein Lumbini zone and Chitwan District of Nepal. Ophthalmic Epidemiol. 2010;17:276–81.CrossRefPubMed
39.
go back to reference Varma R, Kim JS, Burkemper BS, et al. Prevalence and causes of visual impairment and blindness in Chinese American adults: the Chinese American eye study. JAMA Ophthalmol. 2016;134(7):785–93.CrossRefPubMed Varma R, Kim JS, Burkemper BS, et al. Prevalence and causes of visual impairment and blindness in Chinese American adults: the Chinese American eye study. JAMA Ophthalmol. 2016;134(7):785–93.CrossRefPubMed
40.
go back to reference Liang YB, Friedman DS, Wong TY, et al. Prevalence and causes of low vision and blindness in a rural Chinese adult population. The Handan Eye Study Ophthalmology. 2008;115:1965–72. Liang YB, Friedman DS, Wong TY, et al. Prevalence and causes of low vision and blindness in a rural Chinese adult population. The Handan Eye Study Ophthalmology. 2008;115:1965–72.
41.
go back to reference Resnikoff S, Pacolini D, Etya’ale D, et al. Global data on the visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844–51.PubMedPubMedCentral Resnikoff S, Pacolini D, Etya’ale D, et al. Global data on the visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844–51.PubMedPubMedCentral
42.
go back to reference Thapa R, Paudyal G, Shrestha MK, Gurung R, Age-related RS. Macular degeneration in Nepal. Kathmandu Univ Med J. 2011;35(3):165–9. Thapa R, Paudyal G, Shrestha MK, Gurung R, Age-related RS. Macular degeneration in Nepal. Kathmandu Univ Med J. 2011;35(3):165–9.
43.
go back to reference Klein R, Klein BEK, KLP L. Prevalence of age-related maculopathy. The beaver dam eye study. Ophthalmology. 1992;99:933–43.CrossRefPubMed Klein R, Klein BEK, KLP L. Prevalence of age-related maculopathy. The beaver dam eye study. Ophthalmology. 1992;99:933–43.CrossRefPubMed
44.
go back to reference Raman R, Pal SS, Ganesan S, Gella L, Vaitheeswaran K, Sharma T. The prevalence and risk factors for age-related macular degeneration in rural-urban India, SankaraNethralaya rural-urban age-related macular degeneration study, report no. 1. Eye. 2016;30(5):688–97.CrossRefPubMedPubMedCentral Raman R, Pal SS, Ganesan S, Gella L, Vaitheeswaran K, Sharma T. The prevalence and risk factors for age-related macular degeneration in rural-urban India, SankaraNethralaya rural-urban age-related macular degeneration study, report no. 1. Eye. 2016;30(5):688–97.CrossRefPubMedPubMedCentral
45.
go back to reference Woo JH, Sanjay S, AuEong KG. The epidemiology of age-related macular degeneration in the Indian subcontinent. Acta Ophthalmol. 2009;87(3):262–9.CrossRefPubMed Woo JH, Sanjay S, AuEong KG. The epidemiology of age-related macular degeneration in the Indian subcontinent. Acta Ophthalmol. 2009;87(3):262–9.CrossRefPubMed
46.
go back to reference Thapa R, BajimayaS BR, Paudyal G, Khanal S, Tan S, Thapa SS. Intra and inter rater agreement between an ophthalmologist and mid level ophthalmic personnel to diagnose retinal diseases based on fundus photographs at a primary eye center in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2016;16:112.CrossRefPubMedPubMedCentral Thapa R, BajimayaS BR, Paudyal G, Khanal S, Tan S, Thapa SS. Intra and inter rater agreement between an ophthalmologist and mid level ophthalmic personnel to diagnose retinal diseases based on fundus photographs at a primary eye center in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2016;16:112.CrossRefPubMedPubMedCentral
47.
go back to reference Nirmalan PK, Robin AL, Katz J, et al. Prevalence of vitreo-retinal disorders in a rural population of southern India: the Aravind comprehensive eye study. Arch Ophthalmol. 2004;122:581–6.CrossRefPubMed Nirmalan PK, Robin AL, Katz J, et al. Prevalence of vitreo-retinal disorders in a rural population of southern India: the Aravind comprehensive eye study. Arch Ophthalmol. 2004;122:581–6.CrossRefPubMed
48.
go back to reference Zadoon MZ, Dineen B, Bourne RRA, et al. Prevalence of blindness and visual impairment in Pakistan: the Pakistan National Blindness and visual impairment survey. Invest Ophthalmol Vis Sci. 2006;47:4749–55.CrossRef Zadoon MZ, Dineen B, Bourne RRA, et al. Prevalence of blindness and visual impairment in Pakistan: the Pakistan National Blindness and visual impairment survey. Invest Ophthalmol Vis Sci. 2006;47:4749–55.CrossRef
49.
go back to reference Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS. Population awareness of diabetic eye disease and age related macular degeneration in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2015;15:188.CrossRefPubMedPubMedCentral Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS. Population awareness of diabetic eye disease and age related macular degeneration in Nepal: the Bhaktapur retina study. BMC Ophthalmol. 2015;15:188.CrossRefPubMedPubMedCentral
Metadata
Title
Prevalence and causes of low vision and blindness in an elderly population in Nepal: the Bhaktapur retina study
Authors
Raba Thapa
Sanyam Bajimaya
Govinda Paudyal
Shankar Khanal
Stevie Tan
Suman S. Thapa
G. H. M. B. van Rens
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-018-0710-9

Other articles of this Issue 1/2018

BMC Ophthalmology 1/2018 Go to the issue