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Open Access 01-12-2018 | Research article

Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever

Authors: Burak Tanyıldız, Mehmet Engin Tezcan, Baran Kandemir, Nesrin Tutaş Günaydın, Eren Göktaş, Aise Tangılntız, Aysu Karatay Arsan

Published in: BMC Ophthalmology | Issue 1/2018

Abstract

Background

The purpose of this study is to investigate whether oral colchicine has an effect on peripapillary retinal nerve fiber layer (pRNFL) thickness of familial Mediterranean fever (FMF) patients.

Methods

We conducted a cross sectional study by comparing pRNFL thickness of FMF patients on colchicine (treated group), newly diagnosed colchicine naïve FMF patients (untreated group) and healthy controls. The study included 66 FMF patients and 32 healthy control subjects. Treated FMF patients were grouped according to colchicine use, duration of use and dosage. pRNFL thickness of the patients and controls were measured by using optical coherence tomography and the measurements were compared.

Results

No statistically significant difference was found between the pRNFL thickness in untreated group, treated group and the healthy control group (all p > 0.05). No statistically significant difference was found between pRNFL thickness in the healthy control group and FMF patients grouped according to duration or dosage of colchicine use (all p > 0.05).

Conclusions

According to our study, FMF and oral colchicine use had no statistically significant effect on pRNFL thickness.

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Title: Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever
Authors: Burak Tanyıldız
Mehmet Engin Tezcan
Baran Kandemir
Nesrin Tutaş Günaydın
Eren Göktaş
Aise Tangılntız
Aysu Karatay Arsan
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-018-0698-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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