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Published in: BMC Ophthalmology 1/2017

Open Access 01-12-2017 | Research article

The peripheral and Central Humphrey visual field – morphological changes during aging

Authors: Paul Rutkowski, Christian Albrecht May

Published in: BMC Ophthalmology | Issue 1/2017

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Abstract

Background

To define age-related changes in the visual field by comparing ‘standard’ central and unique peripheral visual field measurements in healthy volunteers.

Methods

In a single center, retrospective, Cross-sectional, observational study, 20 volunteers with no retinal diseases or risk factors, ranging in age between 30 and 94 years (four age groups: 30’s, 50’s, 70’s, 90’s) were measured in one eye (preferentially the right one) using a Humphrey visual field 24–2 and 60–4.

Results

While the central visual field remained relatively well preserved during aging showing only a mild reduction in sensitivity, a profound loss of the peripheral visual field was observed beginning in the fifth decade of life and decreasing continuously up to the 90ies.

Conclusions

The peripheral visual field declined substantially from the 4th decade onward while the central visual field remained quite stable.
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Literature
1.
go back to reference Creuzot-Garcher C, Binquet C, Daniel S, Bretillon L, Acar N, de Lazzer A, Arnould L, Tzourio C, Bron AM, Delcourt C. The Montrachet study: study design, methodology and analysis of visual acuity and refractive errors in an elderly population. Acta Ophthalmol. 2016;94:e90–7.CrossRefPubMed Creuzot-Garcher C, Binquet C, Daniel S, Bretillon L, Acar N, de Lazzer A, Arnould L, Tzourio C, Bron AM, Delcourt C. The Montrachet study: study design, methodology and analysis of visual acuity and refractive errors in an elderly population. Acta Ophthalmol. 2016;94:e90–7.CrossRefPubMed
2.
go back to reference Matsui Y, Oikawa S, Aoki Y, Sekine M, Mitobe K. Features of the vision of elderly pedestrians when crossing a road. Stapp Car Crash J. 2014;58:233–50.PubMed Matsui Y, Oikawa S, Aoki Y, Sekine M, Mitobe K. Features of the vision of elderly pedestrians when crossing a road. Stapp Car Crash J. 2014;58:233–50.PubMed
3.
go back to reference Urwyler P, Gruber N, Müri RM, Jäger M, Bieri R, Nyffeler T, Mosimann UP, Nef T. Age-dependent visual exploration during simulated day- and night driving on a motorway: a cross-sectional study. BMC Geriatr. 2015;15:18.CrossRefPubMedPubMedCentral Urwyler P, Gruber N, Müri RM, Jäger M, Bieri R, Nyffeler T, Mosimann UP, Nef T. Age-dependent visual exploration during simulated day- and night driving on a motorway: a cross-sectional study. BMC Geriatr. 2015;15:18.CrossRefPubMedPubMedCentral
4.
go back to reference Curcio CA, Drucker DN. Retinal ganglion cells in Alzheimer’s disease and aging. Ann Neurol. 1993;33:248–57.CrossRefPubMed Curcio CA, Drucker DN. Retinal ganglion cells in Alzheimer’s disease and aging. Ann Neurol. 1993;33:248–57.CrossRefPubMed
5.
go back to reference Harman A, Abrahams B, Moore S, Hoskins R. Neuronal density in the human retinal ganglion cell layer from 16-77 years. Anat Rec. 2000;260:124–31.CrossRefPubMed Harman A, Abrahams B, Moore S, Hoskins R. Neuronal density in the human retinal ganglion cell layer from 16-77 years. Anat Rec. 2000;260:124–31.CrossRefPubMed
6.
go back to reference Cavallotti C, Artico M, Pescosolido N, Leali FM, Feher J. Age-related changes in the human retina. Can J Ophthalmol. 2004;39:61–8.CrossRefPubMed Cavallotti C, Artico M, Pescosolido N, Leali FM, Feher J. Age-related changes in the human retina. Can J Ophthalmol. 2004;39:61–8.CrossRefPubMed
7.
go back to reference Lei Y, Garrahan N, Hermann B, Fautsch MP, Johnson DH, Hernandez MR, Boulton M, Morgan JE. Transretinal degeneration in ageing human retina: a multiphoton microscopy analysis. Br J Ophthalmol. 2011;95:727–30.CrossRefPubMed Lei Y, Garrahan N, Hermann B, Fautsch MP, Johnson DH, Hernandez MR, Boulton M, Morgan JE. Transretinal degeneration in ageing human retina: a multiphoton microscopy analysis. Br J Ophthalmol. 2011;95:727–30.CrossRefPubMed
8.
9.
go back to reference Balazsi AG, Rootman J, Drance SM, Schulzer M, Douglas GR. The effect of age on the nerve fiber population of the human optic nerve. Am J Ophthalmol. 1984;97:760–6.CrossRefPubMed Balazsi AG, Rootman J, Drance SM, Schulzer M, Douglas GR. The effect of age on the nerve fiber population of the human optic nerve. Am J Ophthalmol. 1984;97:760–6.CrossRefPubMed
10.
go back to reference Mikelberg FS, Drance SM, Schulzer M, Yidegiligne HM, Weis MM. The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology. 1989;96:1325–8.CrossRefPubMed Mikelberg FS, Drance SM, Schulzer M, Yidegiligne HM, Weis MM. The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology. 1989;96:1325–8.CrossRefPubMed
11.
go back to reference Jonas JB, Schmidt AM, Müller-Bergh JA, Schlötzer-Schrehardt UM, Naumann GO. Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci. 1992;33:2012–8.PubMed Jonas JB, Schmidt AM, Müller-Bergh JA, Schlötzer-Schrehardt UM, Naumann GO. Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci. 1992;33:2012–8.PubMed
12.
go back to reference Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci. 2000;41:741–8.PubMed Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci. 2000;41:741–8.PubMed
13.
go back to reference Repka MX, Quigley HA. The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology. 1989;96:26–32.CrossRefPubMed Repka MX, Quigley HA. The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology. 1989;96:26–32.CrossRefPubMed
14.
go back to reference Parikh RS, Parikh SR, Sekhar GC, Prabakaran S, Babu JG, Thomas R. Normal age-related decay of retinal nerve fiber layer thickness. Ophthalmology. 2007;114:921–6.CrossRefPubMed Parikh RS, Parikh SR, Sekhar GC, Prabakaran S, Babu JG, Thomas R. Normal age-related decay of retinal nerve fiber layer thickness. Ophthalmology. 2007;114:921–6.CrossRefPubMed
15.
go back to reference Mwanza JC, Durbin MK, Budenz DL. Cirrus OCT normative database study group. Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the cirrus HD-OCT in healthy eyes. Am J Ophthalmol. 2011;151:514–21.CrossRefPubMedPubMedCentral Mwanza JC, Durbin MK, Budenz DL. Cirrus OCT normative database study group. Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the cirrus HD-OCT in healthy eyes. Am J Ophthalmol. 2011;151:514–21.CrossRefPubMedPubMedCentral
16.
go back to reference O'Leary N, Artes PH, Hutchison DM, Nicolela MT, Chauhan BC. Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects. Eye (Lond). 2012;26:1554–62.CrossRef O'Leary N, Artes PH, Hutchison DM, Nicolela MT, Chauhan BC. Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects. Eye (Lond). 2012;26:1554–62.CrossRef
17.
go back to reference Leung CK, Yu M, Weinreb RN, Ye C, Liu S, Lai G, Lam DS. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology. 2012;119:731–7.CrossRefPubMed Leung CK, Yu M, Weinreb RN, Ye C, Liu S, Lai G, Lam DS. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology. 2012;119:731–7.CrossRefPubMed
19.
go back to reference Brenton RS, Phelps CD. The normal visual field on the Humphrey field analyzer. Ophthalmologica. 1986;193:56–74.CrossRefPubMed Brenton RS, Phelps CD. The normal visual field on the Humphrey field analyzer. Ophthalmologica. 1986;193:56–74.CrossRefPubMed
20.
go back to reference Young WO, Stewart WC, Hunt H, Crosswell H. Static threshold variability in the peripheral visual field in normal subjects. Graefes Arch Clin Exp Ophthalmol. 1990;228:454–7.CrossRefPubMed Young WO, Stewart WC, Hunt H, Crosswell H. Static threshold variability in the peripheral visual field in normal subjects. Graefes Arch Clin Exp Ophthalmol. 1990;228:454–7.CrossRefPubMed
21.
go back to reference Midelfart A, Midelfart E, Brodtkorb E. Visual field defects in patients taking vigabatrin. Acta Ophthalmol Scand. 2000;78:580–4.CrossRefPubMed Midelfart A, Midelfart E, Brodtkorb E. Visual field defects in patients taking vigabatrin. Acta Ophthalmol Scand. 2000;78:580–4.CrossRefPubMed
22.
go back to reference Berezina TL, Khouri AS, Kolomeyer AM, Clancy PS, Fechtner RD. Peripheral visual field thresholds using Humphrey field analyzer program 60-4 in normal eyes. Eur J Ophthalmol. 2011;21:415–21.CrossRefPubMed Berezina TL, Khouri AS, Kolomeyer AM, Clancy PS, Fechtner RD. Peripheral visual field thresholds using Humphrey field analyzer program 60-4 in normal eyes. Eur J Ophthalmol. 2011;21:415–21.CrossRefPubMed
23.
go back to reference Drance SM, Berry V, Hughes A. Studies on the effects of age on the central and peripheral isopters of the visual field in normal subjects. Am J Ophthalmol. 1967;63:1667–72.CrossRefPubMed Drance SM, Berry V, Hughes A. Studies on the effects of age on the central and peripheral isopters of the visual field in normal subjects. Am J Ophthalmol. 1967;63:1667–72.CrossRefPubMed
24.
go back to reference Krey HF. Distribution of arterioles, capillaries and venules in the equatorial choroid of the human eye. Ophthalmologica. 1981;183:20–3.CrossRefPubMed Krey HF. Distribution of arterioles, capillaries and venules in the equatorial choroid of the human eye. Ophthalmologica. 1981;183:20–3.CrossRefPubMed
25.
go back to reference Okun E. Gross and microscopic pathology in autopsy eyes part II: peripheral chorioretinal atrophy. Am J Ophthalmol. 1960;50:574–83.CrossRefPubMed Okun E. Gross and microscopic pathology in autopsy eyes part II: peripheral chorioretinal atrophy. Am J Ophthalmol. 1960;50:574–83.CrossRefPubMed
26.
go back to reference Krey H. Die Morphologie der peripheren Choriocapillaris in verschiedenen Lebensaltern. Klin Mbl Augenheilk. 1975;167:295–301.PubMed Krey H. Die Morphologie der peripheren Choriocapillaris in verschiedenen Lebensaltern. Klin Mbl Augenheilk. 1975;167:295–301.PubMed
27.
go back to reference Newsome DA, Huh W, Green WR. Bruch’s membrane age-related changes vary by region. Curr Eye Res. 1987;6:1211–21.CrossRefPubMed Newsome DA, Huh W, Green WR. Bruch’s membrane age-related changes vary by region. Curr Eye Res. 1987;6:1211–21.CrossRefPubMed
28.
go back to reference Holz FG, Sheraidah G, Pauleikhoff D, Bird AC. Analysis of lipid deposits extracted from human macular and peripheral Bruch’s membrane. Arch Ophthalmol. 1994;112:402–6.CrossRefPubMed Holz FG, Sheraidah G, Pauleikhoff D, Bird AC. Analysis of lipid deposits extracted from human macular and peripheral Bruch’s membrane. Arch Ophthalmol. 1994;112:402–6.CrossRefPubMed
29.
go back to reference Curcio CA, Millican CL, Bailey T, Kruth HS. Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci. 2001;42:265–74.PubMed Curcio CA, Millican CL, Bailey T, Kruth HS. Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci. 2001;42:265–74.PubMed
30.
go back to reference Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM. The lipid composition of drusen, Bruch’s membrane, and sclera by hot stage polarizing light microscopy. Invest Ophthalmol Vis Sci. 2001;42:1592–9.PubMed Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM. The lipid composition of drusen, Bruch’s membrane, and sclera by hot stage polarizing light microscopy. Invest Ophthalmol Vis Sci. 2001;42:1592–9.PubMed
31.
go back to reference Johnson M, Dabholkar A, Huang J-D, Presley JB, Chimento MF, Curcio CA. Comparison of morphology of human macular and peripheral Bruch’s membrane in older eyes. Curr Eye Res. 2007;32:791–9.CrossRefPubMedPubMedCentral Johnson M, Dabholkar A, Huang J-D, Presley JB, Chimento MF, Curcio CA. Comparison of morphology of human macular and peripheral Bruch’s membrane in older eyes. Curr Eye Res. 2007;32:791–9.CrossRefPubMedPubMedCentral
32.
go back to reference Rutkowski P, May CA. Long-term follow-up of ocular hypertension: a plea for peripheral visual field analysis. Int J Case Studies. 2017;6(3):11–4. Rutkowski P, May CA. Long-term follow-up of ocular hypertension: a plea for peripheral visual field analysis. Int J Case Studies. 2017;6(3):11–4.
Metadata
Title
The peripheral and Central Humphrey visual field – morphological changes during aging
Authors
Paul Rutkowski
Christian Albrecht May
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2017
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-017-0522-3

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