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Published in: BMC Ophthalmology 1/2016

Open Access 01-12-2016 | Research article

Assessment of the prevalence and risk factors of ophthalmoplegia among diabetic patients in a large national diabetes registry cohort

Authors: Eman S. Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M. Youssef, Heba M. Ibrahim, Ahmed H. Al-Sharqawi

Published in: BMC Ophthalmology | Issue 1/2016

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Abstract

Background

There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients.

Methods

This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases. Demographic, clinical, and biochemical parameters were studied and STROBE guidelines were used to design and report the results of this study.

Results

The overall prevalence of ophthalmoplegia cases was 0.32 %, further distributed into: 53.11 %, 36.36 %, and 2.8 % for cranial nerves VI, III, IV palsies respectively. Ophthalmoplegic cases were predominantly type 2 diabetic males with older age and longer diabetes duration. The most important and significant risk factors were age ≥ 45 years, diabetes duration ≥ 10 years, male gender and presence of retinopathy and nephropathy.

Conclusions

Ophthalmoplegia is a rare entity associated mainly with type 2 diabetes. Clinicians have to consider its risk factors when screening or planning for prevention of this condition.
Literature
2.
go back to reference El Mansouri Y, Zaghloul K, Amraoui A. Oculomotor paralyses in the course of diabetes--concerning 12 cases. J Fr Ophtalmol. 2000;23(1):14–8.PubMed El Mansouri Y, Zaghloul K, Amraoui A. Oculomotor paralyses in the course of diabetes--concerning 12 cases. J Fr Ophtalmol. 2000;23(1):14–8.PubMed
3.
go back to reference Richards BW, Jones FR, Younge BR. Causes and prognosis in 4,278 cases of paralysis of the oculomotor, trochlear, and abducens cranial nerves. Am J Ophthalmol. 1992;113(5):489–96.CrossRefPubMed Richards BW, Jones FR, Younge BR. Causes and prognosis in 4,278 cases of paralysis of the oculomotor, trochlear, and abducens cranial nerves. Am J Ophthalmol. 1992;113(5):489–96.CrossRefPubMed
4.
go back to reference Greco D, Gambina F, Pisciotta M, Abrignani M, Maggio F. Clinical characteristics and associated comorbidities in diabetic patients with cranial nerve palsies. J Endocrinol Invest. 2012;35(2):146–9. doi:10.3275/7574.PubMed Greco D, Gambina F, Pisciotta M, Abrignani M, Maggio F. Clinical characteristics and associated comorbidities in diabetic patients with cranial nerve palsies. J Endocrinol Invest. 2012;35(2):146–9. doi:10.​3275/​7574.PubMed
6.
go back to reference Watanabe K, Hagura R, Akanuma Y, et al. Characteristics of cranial nerve palsies in diabetic patients. Diabetes Res ClinPract. 1990;10(1):19–27.CrossRef Watanabe K, Hagura R, Akanuma Y, et al. Characteristics of cranial nerve palsies in diabetic patients. Diabetes Res ClinPract. 1990;10(1):19–27.CrossRef
7.
go back to reference Al Saleh M, Bosley TM. Microvascular cranial nerve palsies in an Arabic population. J Neuroophthalmol. 1999;19(4):252–6.CrossRefPubMed Al Saleh M, Bosley TM. Microvascular cranial nerve palsies in an Arabic population. J Neuroophthalmol. 1999;19(4):252–6.CrossRefPubMed
8.
go back to reference Chebel S, Bouatay AB, Ammar M, Ben-Yahia S, Khairallah M, Ayed MF. Diabetes mellitus-associated ocular motor nerve palsies. Neurosciences (Riyadh). 2009;14(4):386–8. Chebel S, Bouatay AB, Ammar M, Ben-Yahia S, Khairallah M, Ayed MF. Diabetes mellitus-associated ocular motor nerve palsies. Neurosciences (Riyadh). 2009;14(4):386–8.
11.
go back to reference Chugh JP, Chouhan RS, Rathi A. Third nerve palsy: an overview. Indian J ClinPract. 2012;22(12):17–20. Chugh JP, Chouhan RS, Rathi A. Third nerve palsy: an overview. Indian J ClinPract. 2012;22(12):17–20.
14.
go back to reference Lazzaroni F, Laffi GL, Galuppi V, Scorolli L. Paralysis of oculomotor nerves in diabetes mellitus. A retrospective study of 44 cases. Rev Neurol (Paris). 1993;149(10):571–3. Lazzaroni F, Laffi GL, Galuppi V, Scorolli L. Paralysis of oculomotor nerves in diabetes mellitus. A retrospective study of 44 cases. Rev Neurol (Paris). 1993;149(10):571–3.
16.
17.
go back to reference Shih M-H, Huang F-C, Tsai R-K. Ischemic ophthalmoplegia in diabetic mellitus. Neuro-Ophthalmology. 2002;26(3):181–91.CrossRef Shih M-H, Huang F-C, Tsai R-K. Ischemic ophthalmoplegia in diabetic mellitus. Neuro-Ophthalmology. 2002;26(3):181–91.CrossRef
18.
go back to reference Cramer JA, Pugh MJ. The influence of insulin use on glycemic control: how well do adults follow prescriptions for insulin? Diabetes Care. 2005;28(1):78–83.CrossRefPubMed Cramer JA, Pugh MJ. The influence of insulin use on glycemic control: how well do adults follow prescriptions for insulin? Diabetes Care. 2005;28(1):78–83.CrossRefPubMed
19.
go back to reference Noh KM, Lee JC, Ahn YH, Hong SH, Koh JY. Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors. IUBMB Life. 1999;48(3):263–9. doi:10.1080/713803514.CrossRefPubMed Noh KM, Lee JC, Ahn YH, Hong SH, Koh JY. Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors. IUBMB Life. 1999;48(3):263–9. doi:10.​1080/​713803514.CrossRefPubMed
21.
go back to reference Ostrić M, Vrca A, Kolak I, Franolić M, Vrca NB. Cranial nerve lesion in diabetic patients. CollAntropol. 2011;35 Suppl 2:131–6. Ostrić M, Vrca A, Kolak I, Franolić M, Vrca NB. Cranial nerve lesion in diabetic patients. CollAntropol. 2011;35 Suppl 2:131–6.
22.
go back to reference Boulton AJM, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27(6):1458–86.CrossRefPubMed Boulton AJM, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27(6):1458–86.CrossRefPubMed
23.
go back to reference Kobashi R, Ohtsuki H, Hasebe S. Clinical studies of ocular motility disturbances: Part 2. Risk factors for ischemic ocular motor nerve palsy [corrected]. Jpn J Ophthalmol. 1997;41(2):115–9.CrossRefPubMed Kobashi R, Ohtsuki H, Hasebe S. Clinical studies of ocular motility disturbances: Part 2. Risk factors for ischemic ocular motor nerve palsy [corrected]. Jpn J Ophthalmol. 1997;41(2):115–9.CrossRefPubMed
Metadata
Title
Assessment of the prevalence and risk factors of ophthalmoplegia among diabetic patients in a large national diabetes registry cohort
Authors
Eman S. Al Kahtani
Rajiv Khandekar
Khalid Al-Rubeaan
Amira M. Youssef
Heba M. Ibrahim
Ahmed H. Al-Sharqawi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2016
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-016-0272-7

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