Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2015

Open Access 01-12-2015 | Research article

Central corneal sensitivity after small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a meta-analysis of comparative studies

Authors: Miao He, Wenyong Huang, Xingwu Zhong

Published in: BMC Ophthalmology | Issue 1/2015

Login to get access

Abstract

Background

The aim of this study was to evaluate central corneal sensitivity after small incision lenticule extraction (SMILE) versus femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for myopia.

Methods

Eligible studies were identified by systematically searching PubMed, the Cochrane Library, Embase and the Chinese Biomedicine Database. Central corneal sensitivity after SMILE versus FS-LASIK was assessed by the pooled weighted mean differences (WMDs) of the reduction from pre-operation levels to 1 week, 1, 3 and 6 months following the operation. The quality of the included literature was assessed by the Quality Index. Data were synthesized by Stata 12.0 SE for Windows.

Results

Five studies involving 245 patients (363 eyes; 189 eyes in the FS-LASIK group and 174 eyes in the SMILE group) were included in the meta-analysis. The pooled results showed that there were no significant differences in central corneal sensitivity between FS-LASIK and SMILE before surgery (WMD = 0 mm, 95 % CI: −0.23 to −0.23, p = 0.998). At 1 week, 1 and 3 months after surgery, the central corneal sensitivity after FS-LASIK was lower than with SMILE (WMD = −17.35 mm, 95 % CI: −26.54 to −8.16, p <0.001; WMD = −17.52 mm, 95 % CI: −25.10 to −9.94, p <0.001; WMD = −14.64 mm, 95 % CI: −20.08 to −9.21, p <0.001, respectively). However, central corneal sensitivity after FS-LASIK was similar with SMILE 6 months after surgery (WMD = −2.02 mm, 95 % CI: −4.23 to 0.19, p = 0.074).

Conclusion

Central corneal sensitivity exhibited a small decrease and a faster recovery after the SMILE procedure compared to FS-LASIK during the first three postoperative months. Corneal sensitivity after SMILE and FS-LASIK was similar at 6 months after surgery. However, these results should be interpreted with caution due to the limited number of studies.
Literature
1.
Stern D, Schoenlein RW, Puliafito CA, Dobi ET, Birngruber R, Fujimoto JG. Corneal ablation by nanosecond, picosecond, and femtosecond lasers at 532 and 625 nm. Arch Ophthalmol. 1989;107:587–92.CrossRefPubMed
2.
Slade SG. The use of the femtosecond laser in the customization of corneal flaps in laser in situ keratomileusis. CurrOpinOphthalmol. 2007;18:314–7.
3.
Ambrosio RJ, Tervo T, Wilson SE. LASIK-associated dry eye and neurotrophicepitheliopathy: pathophysiology and strategies for prevention and treatment. J Refract Surg. 2008;24:396–407.PubMed
4.
Friedlaender MH. LASIK surgery using the IntraLase femtosecond laser. IntOphthalmolClin. 2006;46:145–53.
5.
6.
Demirok A, Ozgurhan EB, Agca A, Kara N, Bozkurt E, Cankaya KI, et al. Corneal sensation after corneal refractive surgery with small incision lenticule extraction. Optom Vis Sci. 2013;90:1040–7.CrossRefPubMed
7.
Gao S, Li S, Liu L, Wang Y, Ding H, Li L, et al. Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis. PLoS One. 2014;9:e107370.CrossRefPubMedPubMedCentral
8.
Li M, Niu L, Qin B, Zhou Z, Ni K, Le Q, et al. Confocal comparison of corneal reinnervation after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK). PLoS One. 2013;8:e81435.CrossRefPubMedPubMedCentral
9.
Li M, Zhao J, Shen Y, Li T, He L, Xu H, et al. Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia. PLoS One. 2013;8:e77797.CrossRefPubMedPubMedCentral
10.
Wei S, Wang Y. Comparison of corneal sensitivity between FS-LASIK and femtosecond lenticule extraction (ReLEx flex) or small-incision lenticule extraction (ReLEx smile) for myopic eyes. Graefes Arch ClinExpOphthalmol. 2013;251:1645–54.CrossRef
11.
Jiang MS, Yuan Y, Gu ZX, Zhuang SL. Corneal confocal microscopy for assessment of diabetic peripheral neuropathy: a meta-analysis. Br J Ophthalmol. 2015.
12.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J ClinEpidemiol. 2009;62:1006–12.
13.
Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [updated March, 2011]. 2011. Available from: www.​cochrane-handbook.​org; 2011. edn: The Cochrane Collaboration.
14.
15.
Cheng JW, Cai JP, Wei RL. Meta-analysis of medical intervention for normal tension glaucoma. Ophthalmology. 2009;116:1243–9.CrossRefPubMed
16.
17.
18.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.CrossRefPubMed
19.
Toda I, Asano-Kato N, Komai-Hori Y, Tsubota K. Dry eye after laser in situ keratomileusis. Am J Ophthalmol. 2001;132:1–7.CrossRefPubMed
20.
Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001;108:1230–5.CrossRefPubMed
21.
Nassaralla BA, McLeod SD, Nassaralla JJ. Effect of myopic LASIK on human corneal sensitivity. Ophthalmology. 2003;110:497–502.CrossRefPubMed
22.
Kumano Y, Matsui H, Zushi I, Mawatari A, Matsui T, Nishida T, et al. Recovery of corneal sensation after myopic correction by laser in situ keratomileusis with a nasal or superior hinge. J Cataract Refract Surg. 2003;29:757–61.CrossRefPubMed
23.
Sekundo W, Kunert KS, Blum M. Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study. Br J Ophthalmol. 2011;95:335–9.CrossRefPubMed
24.
Zhang F, Deng S, Guo N, Wang M, Sun X. Confocal comparison of corneal nerve regeneration and keratocyte reaction between FS-LASIK, OUP-SBK, and conventional LASIK. Invest Ophthalmol Vis Sci. 2012;53:5536–44.CrossRefPubMed
25.
Micera A, Lambiase A, Puxeddu I, Aloe L, Stampachiacchiere B, Levi-Schaffer F, et al. Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healing. Exp Eye Res. 2006;83:747–57.CrossRefPubMed
26.
Sornelli F, Lambiase A, Mantelli F, Aloe L. NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells. Mol Vis. 2010;16:1439–47.PubMedPubMedCentral
27.
Nejima R, Miyata K, Tanabe T, Okamoto F, Hiraoka T, Kiuchi T, et al. Corneal barrier function, tear film stability, and corneal sensation after photorefractive keratectomy and laser in situ keratomileusis. Am J Ophthalmol. 2005;139:64–71.CrossRefPubMed
28.
Nakamura Y, Sotozono C, Kinoshita S. Inflammatory cytokines in normal human tears. Curr Eye Res. 1998;17:673–6.CrossRefPubMed
29.
Massingale ML, Li X, Vallabhajosyula M, Chen D, Wei Y, Asbell PA. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea. 2009;28:1023–7.CrossRefPubMed
30.
Ebihara N, Matsuda A, Nakamura S, Matsuda H, Murakami A. Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci. 2011;52:8549–57.CrossRefPubMed
31.
Lee SJ, Kim JK, Seo KY, Kim EK, Lee HK. Comparison of corneal nerve regeneration and sensitivity between LASIK and laser epithelialkeratomileusis (LASEK). Am J Ophthalmol. 2006;141:1009–15.CrossRefPubMed
Metadata
Title
Central corneal sensitivity after small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a meta-analysis of comparative studies
Authors
Miao He
Wenyong Huang
Xingwu Zhong
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2015
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-015-0129-5

Other articles of this Issue 1/2015

BMC Ophthalmology 1/2015 Go to the issue

Research article

Structure/Function relationship and retinal ganglion cells counts to discriminate glaucomatous damages

Technical advance

Combining macula clinical signs and patient characteristics for age-related macular degeneration diagnosis: a machine learning approach

Research article

Progression of lower and higher-order aberrations: a longitudinal study

Research article

Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis

Research article

Long-term outcomes of argon laser photocoagulation in small size cyclodialysis cleft

Research article

One year results of intravitreal ranibizumab monotherapy for retinal angiomatous proliferation: a comparative analysis based on disease stages