Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2015

Open Access 01-12-2015 | Research article

Effect of diabetic retinopathy and diabetes on the intraocular straylight in pseudophakic eyes

Authors: Hyung Bin Hwang, Hye Bin Yim, Sung Kun Chung

Published in: BMC Ophthalmology | Issue 1/2015

Login to get access

Abstract

Background

The aim of this study was to prove the relationship between the intraocular straylight level and diabetic retinopathy (DR) according to disease severity. Also, we aimed to evaluate whether diabetes mellitus (DM) per se could be a risk factor of increased intraocular straylight although we did not rely on a definite sign of DR in this study.

Methods

In this prospective comparative study, ninety three eyes were enrolled and divided into four groups as follows: Group 1 (26 eyes), without DR or DM; Group 2 (25 eyes), with DM but without DR; Group 3 (21 eyes), mild to moderate non-proliferative DR; and Group 4 (21 eyes), severe non-proliferative DR. To measure the intraocular straylight in an objective manner, the C-quant straylight meter was used to preoperatively and 2 months postoperatively in all patients who underwent phacoemulsification surgery. All the patients also underwent a macular optical coherence tomography and hemoglobin A1c (HbA1c) analysis. A comparison of straylight levels adjusted by age among four groups was performed postoperatively.

Results

The postoperative level of intraocular straylight was statistically significantly different among four groups (P <0.05). When adjusted for ages, Group 4 showed the highest straylight level when compared with Group 3 and the other two groups (P <0.05). Group 1 showed the lowest straylight level in comparison with Group 2 and the other two groups (P <0.05). There was no significant correlation between HbA1c level, duration of diabetes and postoperative straylight level.

Conclusions

The level of intraocular straylight at 2 months postoperatively had a tendency to increase as the severity of DR increased. Additionally, the straylight level was higher in DM patients without DR than in patients without DM. Therefore, the severity of DR seemed to influence the intraocular straylight level. Although there is no definite sign of DR, DM per se can be a risk factor for increasing intraocular straylight. In conclusion, the level of intraocular straylight seems to be a sensitive test for detecting early retinal damage secondary to DM.
Literature
1.
van den Berg TJ. Importance of pathological intraocular light scatter for visual disability. Doc Ophthalmol. 1986;61(3–4):327–33.CrossRefPubMed
2.
van den Berg TJ. Analysis of intraocular straylight, especially in relation to age. Optom Vis Sci. 1995;72(2):52–9.CrossRefPubMed
3.
Koh S, Maeda N, Ikeda C, Asonuma S, Mitamura H, Oie Y, et al. Ocular forward light scattering and corneal backward light scattering in patients with dry eye. Invest Ophthalmol Vis Sci. 2014;55(10):6601–6.CrossRefPubMed
4.
Griffiths SN, Drasdo N, Barnes DA, Sabell AG. Effect of epithelial and stromal edema on the light scattering properties of the cornea. Am J Optom Physiol Opt. 1986;63(11):888–94.CrossRefPubMed
5.
Lorente-Velazquez A, Gonzalez Mesa A, Gutierrez JR, Villa-Collar C, Nieto-Bona A. Long-term changes in straylight induced by corneal refractive therapy: a pilot study. Cont Lens Anterior Eye. 2014;37(3):144–8.CrossRefPubMed
6.
Beerthuizen JJ, Franssen L, Landesz M, van den Berg TJ. Straylight values 1 month after laser in situ keratomileusis and photorefractive keratectomy. J Cataract Refract Surg. 2007;33(5):779–83.CrossRefPubMed
7.
de Waard PW JKIJ, van den Berg TJ, de Jong PT. Intraocular light scattering in age-related cataracts. Invest Ophthalmol Vis Sci. 1992;33(3):618–25.PubMed
8.
de Vries NE, Franssen L, Webers CA, Tahzib NG, Cheng YY, Hendrikse F, et al. Intraocular straylight after implantation of the multifocal AcrySof ReSTOR SA60D3 diffractive intraocular lens. J Cataract Refract Surg. 2008;34(6):957–62.CrossRefPubMed
9.
Hofmann T, Zuberbuhler B, Cervino A, Montes-Mico R, Haefliger E. Retinal straylight and complaint scores 18 months after implantation of the AcrySof monofocal and ReSTOR diffractive intraocular lenses. J Refract Surg. 2009;25(6):485–92.PubMed
10.
Alexander KR, Fishman GA, Derlacki DJ. Intraocular light scatter in patients with retinitis pigmentosa. Vision Res. 1996;36(22):3703–9.CrossRefPubMed
11.
Grover S, Alexander KR, Choi DM, Fishman GA. Intraocular light scatter in patients with choroideremia. Ophthalmology. 1998;105(9):1641–5.CrossRefPubMed
12.
Grover S, Alexander KR, Fishman GA, Ryan J. Comparison of intraocular light scatter in carriers of choroideremia and X-linked retinitis pigmentosa. Ophthalmology. 2002;109(1):159–63.CrossRefPubMed
13.
Hyvarinen L, Laurinen P, Rovamo J. Contrast sensitivity in evaluation of visual impairment due to diabetes. Acta Ophthalmol (Copenh). 1983;61(1):94–101.CrossRef
14.
Arend O, Remky A, Evans D, Stuber R, Harris A. Contrast sensitivity loss is coupled with capillary dropout in patients with diabetes. Invest Ophthalmol Vis Sci. 1997;38(9):1819–24.PubMed
15.
Dosso AA, Bonvin ER, Morel Y, Golay A, Assal JP, Leuenberger PM. Risk factors associated with contrast sensitivity loss in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 1996;234(5):300–5.CrossRefPubMed
16.
Katz G, Levkovitch-Verbin H, Treister G, Belkin M, Ilany J, Polat U. Mesopic foveal contrast sensitivity is impaired in diabetic patients without retinopathy. Graefes Arch Clin Exp Ophthalmol. 2010;248(12):1699–703.CrossRefPubMed
17.
Franssen L, Coppens JE, van den Berg TJ. Compensation comparison method for assessment of retinal straylight. Invest Ophthalmol Vis Sci. 2006;47(2):768–76.CrossRefPubMed
18.
Cervino A, Gonzalez-Meijome JM, Linhares JM, Hosking SL, Montes-Mico R. Effect of sport-tinted contact lenses for contrast enhancement on retinal straylight measurements. Ophthalmic Physiol Opt. 2008;28(2):151–6.CrossRefPubMed
19.
IJspeert JK, de Waard PW, van den Berg TJ, de Jong PT. The intraocular straylight function in 129 healthy volunteers; dependence on angle, age and pigmentation. Vision Res. 1990;30(5):699–707.CrossRefPubMed
20.
Rodriguez-Fontal M, Kerrison JB, Alfaro DV, Jablon EP. Metabolic control and diabetic retinopathy. Curr Diabetes Rev. 2009;5(1):3–7.CrossRefPubMed
21.
Khosla PK, Talwar D, Tewari HK. Contrast sensitivity changes in background diabetic retinopathy. Can J Ophthalmol. 1991;26(1):7–11.PubMed
22.
Brinchmann-Hansen O, Bangstad HJ, Hultgren S, Fletcher R, Dahl-Jorgensen K, Hanssen KF, et al. Psychophysical visual function, retinopathy, and glycemic control in insulin-dependent diabetics with normal visual acuity. Acta Ophthalmol (Copenh). 1993;71(2):230–7.CrossRef
23.
Schultz RO, Van Horn DL, Peters MA, Klewin KM, Schutten WH. Diabetic keratopathy. Trans Am Ophthalmol Soc. 1981;79:180–99.PubMedPubMedCentral
24.
Takahashi N, Wakuta M, Morishige N, Chikama T, Nishida T, Sumii Y. Development of an instrument for measurement of light scattering at the corneal epithelial basement membrane in diabetic patients. Jpn J Ophthalmol. 2007;51(3):185–90.CrossRefPubMed
25.
Morishige N, Chikama TI, Sassa Y, Nishida T. Abnormal light scattering detected by confocal biomicroscopy at the corneal epithelial basement membrane of subjects with type II diabetes. Diabetologia. 2001;44(3):340–5.CrossRefPubMed
26.
Stitt AW, Moore JE, Sharkey JA, Murphy G, Simpson DA, Bucala R, et al. Advanced glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy. Invest Ophthalmol Vis Sci. 1998;39(13):2517–23.PubMed
27.
28.
Kanellopoulos AJ, Asimellis G, Georgiadou S. Digital pupillometry and centroid shift changes after cataract surgery. J Cataract Refract Surg. 2015;41(2):408–14.CrossRefPubMed
29.
Kanellopoulos AJ, Asimellis G. Clear-cornea cataract surgery: pupil size and shape changes, along with anterior chamber volume and depth changes. A Scheimpflug imaging study. Clin Ophthalmol. 2014;8:2141–50.CrossRefPubMedPubMedCentral
30.
Franssen L, Tabernero J, Coppens JE, van den Berg TJ. Pupil size and retinal straylight in the normal eye. Invest Ophthalmol Vis Sci. 2007;48(5):2375–82.CrossRefPubMed
31.
de Faria JM L, Katsumi O, Cagliero E, Nathan D, Hirose T. Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 2001;239(9):643–8.CrossRef
32.
Elliott DB, Bullimore MA. Assessing the reliability, discriminative ability, and validity of disability glare tests. Invest Ophthalmol Vis Sci. 1993;34(1):108–19.PubMed
33.
Michael R, van Rijn LJ, van den Berg TJ, Barraquer RI, Grabner G, Wilhelm H, et al. Association of lens opacities, intraocular straylight, contrast sensitivity and visual acuity in European drivers. Acta Ophthalmol. 2009;87(6):666–71.CrossRefPubMed
Metadata
Title
Effect of diabetic retinopathy and diabetes on the intraocular straylight in pseudophakic eyes
Authors
Hyung Bin Hwang
Hye Bin Yim
Sung Kun Chung
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2015
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-015-0120-1

Other articles of this Issue 1/2015

BMC Ophthalmology 1/2015 Go to the issue

Research article

Prevalence and risk factors of primary open-angle glaucoma in a city of Eastern China: a population-based study in Pudong New District, Shanghai

Research article

One-year outcomes of small-incision lenticule extraction (SMILE): mild to moderate myopia vs. high myopia

Research article

Living with glaucoma: a qualitative study of functional implications and patients’ coping behaviours

Research article

23-gauge transconjunctival vitrectomy in eyes with pre-existing functioning filtering blebs

Case report

Intraocular myofibroblastoma in an infant: a case report

Research article

Role of Dectin-1 in the innate immune response of rat corneal epithelial cells to Aspergillus fumigatus