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BMC Cancer
Published in: BMC Cancer 1/2020

01-12-2020 | Hodgkin Lymphoma | Review

Improving outcomes after autologous transplantation in relapsed/refractory Hodgkin lymphoma: a European expert perspective

Authors: Anna Sureda, Marc André, Peter Borchmann, Maria G. da Silva, Christian Gisselbrecht, Theodoros P. Vassilakopoulos, Pier Luigi Zinzani, Jan Walewski

Published in: BMC Cancer | Issue 1/2020

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Abstract

Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. However, a considerable number of patients who receive ASCT will progress/relapse and display suboptimal post-transplant outcomes. Over recent years, a number of different strategies have been assessed to improve post-ASCT outcomes and augment HL cure rates. These include use of pre- and post-ASCT salvage therapies and post-ASCT consolidative therapy, with the greatest benefits demonstrated by targeted therapies, such as brentuximab vedotin. However, adoption of these new approaches has been inconsistent across different centers and regions.
In this article, we provide a European perspective on the available treatment options and likely future developments in the salvage and consolidation settings, with the aim to improve management of patients with HL who have a high risk of post-ASCT failure.

Conclusions

We conclude that early intervention with post-ASCT consolidation improves outcomes in patients with R/R HL who require ASCT. Future approvals of targeted agents are expected to further improve outcomes and provide additional treatment options in the coming age of personalized medicine.
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Metadata
Title
Improving outcomes after autologous transplantation in relapsed/refractory Hodgkin lymphoma: a European expert perspective
Authors
Anna Sureda
Marc André
Peter Borchmann
Maria G. da Silva
Christian Gisselbrecht
Theodoros P. Vassilakopoulos
Pier Luigi Zinzani
Jan Walewski
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2020
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-020-07561-2

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