Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Case report

Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report

Authors: Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho, Chae-Yong Kim

Published in: BMC Cancer | Issue 1/2018

Login to get access

Abstract

Back ground

Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-term survival, the adverse effects of RT and late sequelae in survivors are of most concern. So, recently, standard treatment protocol of combination with chemotherapy and reduced dose of RT could be widely acceptable.

Case presentation

We report a patient with germinoma who developed RT-induced glioblastoma. He was diagnosed as biopsy-proven germinoma at the age of 12. Postoperatively, he underwent RT alone without chemotherapy and remained free of tumor without recurrence during long-term follow up. However, after almost 20 year, he developed RT-induced glioblastoma.

Conclusions

Although RT has the highest priority among treatments on intracranial germinomas, RT-only therapy with full dose for germinoma can have delayed severe complications. So, chemotherapy prior to reduced dose RT is more desirable.
Literature
1.
Ogawa K, Shikama N, Toita T, Nakamura K, Uno T, Onishi H, Itami J, Kakinohana Y, Kinjo T, Yoshii Y, et al. Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. Int J Radiat Oncol Biol Phys. 2004;58(3):705–13.CrossRef
2.
Shibamoto Y, Sasai K, Oya N, Hiraoka M. Intracranial germinoma: radiation therapy with tumor volume-based dose selection. Radiology. 2001;218(2):452–6.CrossRef
3.
Yen SH, Chen YW, Huang PI, Wong TT, Ho DM, Chang KP, Liang ML, Chiou SH, Lee YY, Chen HH. Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy? Int J Radiat Oncol Biol Phys. 2010;77(4):980–7.CrossRef
4.
Elsamadicy AA, Babu R, Kirkpatrick JP, Adamson DC. Radiation-induced malignant gliomas: a current review. World Neurosurg. 2015;83(4):530–42.CrossRef
5.
Salvati M, D'Elia A, Melone GA, Brogna C, Frati A, Raco A, Delfini R. Radio-induced gliomas: 20-year experience and critical review of the pathology. J Neuro-Oncol. 2008;89(2):169–77.CrossRef
6.
Salvati M, Frati A, Russo N, Caroli E, Polli FM, Minniti G, Delfini R. Radiation-induced gliomas: report of 10 cases and review of the literature. Surg Neurol. 2003;60(1):60–7 discussion 67.CrossRef
7.
Acharya S, DeWees T, Shinohara ET, Perkins SM. Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas. Neuro-Oncology. 2015;17(5):741–6.CrossRef
8.
Jensen AW, Laack NN, Buckner JC, Schomberg PJ, Wetmore CJ, Brown PD. Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. Int J Radiat Oncol Biol Phys. 2010;77(5):1449–56.CrossRef
9.
Khatua S, Dhall G, O'Neil S, Jubran R, Villablanca JG, Marachelian A, Nastia A, Lavey R, Olch AJ, Gonzalez I, et al. Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer. 2010;55(1):42–6.PubMed
10.
Kretschmar C, Kleinberg L, Greenberg M, Burger P, Holmes E, Wharam M. Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: a report from the Children's oncology group. Pediatr Blood Cancer. 2007;48(3):285–91.CrossRef
11.
Osuka S, Tsuboi K, Takano S, Ishikawa E, Matsushita A, Tokuuye K, Akine Y, Matsumura A. Long-term outcome of patients with intracranial germinoma. J Neuro-Oncol. 2007;83(1):71–9.CrossRef
12.
Murray MJ, Bartels U, Nishikawa R, Fangusaro J, Matsutani M, Nicholson JC. Consensus on the management of intracranial germ-cell tumours. Lancet Oncol. 2015;16(9):e470–7.CrossRef
13.
Diez B, Balmaceda C, Matsutani M, Weiner HL. Germ cell tumors of the CNS in children: recent advances in therapy. Childs Nerv Syst. 1999;15(10):578–85.CrossRef
14.
Rogers SJ, Mosleh-Shirazi MA, Saran FH. Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol. 2005;6(7):509–19.CrossRef
15.
Cahan WG, Woodard HQ, et al. Sarcoma arising in irradiated bone; report of 11 cases. Cancer. 1948;1(1):3–29.CrossRef
16.
Kitanaka C, Shitara N, Nakagomi T, Nakamura H, Genka S, Nakagawa K, Akanuma A, Aoyama H, Takakura K. Postradiation astrocytoma. Report of two cases. J Neurosurg. 1989;70(3):469–74.CrossRef
17.
Nishio S, Morioka T, Inamura T, Takeshita I, Fukui M, Sasaki M, Nakamura K, Wakisaka S. Radiation-induced brain tumours: potential late complications of radiation therapy for brain tumours. Acta Neurochir. 1998;140(8):763–70.CrossRef
18.
You SH, Lyu CJ, Kim DS, Suh CO. Second primary brain tumors following cranial irradiation for pediatric solid brain tumors. Childs Nerv Syst. 2013;29(10):1865–70.CrossRef
19.
Haddock MG, Schild SE, Scheithauer BW, Schomberg PJ. Radiation therapy for histologically confirmed primary central nervous system germinoma. Int J Radiat Oncol Biol Phys. 1997;38(5):915–23.CrossRef
20.
Walter AW, Hancock ML, Pui CH, Hudson MM, Ochs JS, Rivera GK, Pratt CB, Boyett JM, Kun LE. Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's research hospital. J Clin Oncol. 1998;16(12):3761–7.CrossRef
21.
Paulino AC, Mai WY, Chintagumpala M, Taher A, Teh BS. Radiation-induced malignant gliomas: is there a role for reirradiation? Int J Radiat Oncol Biol Phys. 2008;71(5):1381–7.CrossRef
22.
Matsutani M, Japanese pediatric brain tumor study G. Combined chemotherapy and radiation therapy for CNS germ cell tumors--the Japanese experience. J Neuro-Oncol. 2001;54(3):311–6.CrossRef
23.
Eom KY, Kim IH, Park CI, Kim HJ, Kim JH, Kim K, Kim SK, Wang KC, Cho BG, Jung HW, et al. Upfront chemotherapy and involved-field radiotherapy results in more relapses than extended radiotherapy for intracranial germinomas: modification in radiotherapy volume might be needed. Int J Radiat Oncol Biol Phys. 2008;71(3):667–71.CrossRef
24.
Calaminus G, Kortmann R, Worch J, Nicholson JC, Alapetite C, Garre ML, Patte C, Ricardi U, Saran F, Frappaz D. SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuro-Oncology. 2013;15(6):788–96.CrossRef
Metadata
Title
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report
Authors
Kihwan Hwang
Kyu Sang Lee
Gheeyoung Choe
Byung-Gyu Cho
Chae-Yong Kim
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-5073-3

Other articles of this Issue 1/2018

BMC Cancer 1/2018 Go to the issue

Research article

Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening

Research article

GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma

Study protocol

The Promoting Activity in Cancer Survivors (PACES) trial: a multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors

Research article

Dynamic imaging and pathological changes in pig liver after MR-guided microwave ablation

Research article

Doctor, are you healthy? A cross-sectional investigation of oncologist burnout, depression, and anxiety and an investigation of their associated factors

Research article

Investigation of chemotherapy-induced brain structural alterations in breast cancer patients with generalized q-sampling MRI and graph theoretical analysis
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits