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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Case report

Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report

Authors: Lishu Yang, Lizhu Liu, Bo Han, Wei Han, Meng Zhao

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. Apatinib, a novel tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR2), has been approved for the treatment of advanced gastric cancer.

Case presentation

Herein, we report a patient with advanced angiosarcoma, who received apatinib at a daily dose of 250 to 725 mg, resulting in a partial response for three months, which may be related to Kinase Insert Domain Receptor (KDR) gene amplification.

Conclusion

Our experience reported here indicated that apatinib may be a useful therapeutic option for treatment of patients with advanced angiosarcoma.
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Metadata
Title
Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report
Authors
Lishu Yang
Lizhu Liu
Bo Han
Wei Han
Meng Zhao
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4523-2

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