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Open Access 01-12-2018 | Case report

First case of AML with rare chromosome translocations: a case report of twins

Authors: Lin Wang, Yanhua Sun, Yanli Sun, Lingbin Meng, Xin Xu

Published in: BMC Cancer | Issue 1/2018

Abstract

Background

Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized.

Case presentation

Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient’s healthy sibling as a sequencing control.

Conclusion

This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15.

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Title: First case of AML with rare chromosome translocations: a case report of twins
Authors: Lin Wang
Yanhua Sun
Yanli Sun
Lingbin Meng
Xin Xu
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-018-4396-4

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