Skip to main content
Top
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a population-based study

Authors: Mauro Laudicella, Brendan Walsh, Elaine Burns, Paolo Li Donni, Peter C. Smith

Published in: BMC Cancer | Issue 1/2018

Login to get access

Abstract

Background

Studies on alternative routes to diagnosis stimulated successful policy interventions reducing the number of emergency diagnoses and associated mortality risk. A dearth of evidence on the costs of such interventions might prevent new policies from achieving more ambitious targets.

Methods

We conducted a retrospective cohort study on the population of colorectal (88,051), breast (90,387), prostate (96,219), and lung (97,696) cancer patients diagnosed after a GP referral or an emergency presentation and reported in the Cancer Registry of England. Resource use and survival were compared 1 year before and 5 years after diagnosis (3 years for lung), including the costs of GP referrals not converted into a positive diagnosis. Risk-adjusted statistical models were used to calculate the effect of rerouting patient’ diagnoses from emergency presentation to GP referral.

Results

Rerouting a cancer diagnosis results in a relatively small additional costs to the National Health System against additional years of life saved to the patient. The cost per year of life saved is £6456 in colorectal, £1057 in breast, −£662 in prostate (savings), and £819 in lung cancer. Reducing the overall prevalence of emergency presentations to the level achieved by the 20% of Clinical Commissioning Groups with the lowest prevalence would result in £11,481,948 against 1863 years of life saved for Colorectal, £847,750 against 889 years for breast, −£943,434 (cost savings) against 1195 years for prostate, and £609,938 against 1011 years for lung cancer.

Conclusion

Redirecting diagnoses from emergency presentation to GP referral appears an achievable target that can produce large benefits to patients against modest additional costs to the National Health System.
Appendix
Available only for authorised users
Literature
1.
go back to reference Elliss-Brookes L, McPhail S, Ives A, Greenslade M, Shelton J, Hiom S, et al. Routes to diagnosis for cancer - determining the patient journey using multiple routine data sets. Br J Cancer. 2012;107:1220–6.CrossRefPubMedPubMedCentral Elliss-Brookes L, McPhail S, Ives A, Greenslade M, Shelton J, Hiom S, et al. Routes to diagnosis for cancer - determining the patient journey using multiple routine data sets. Br J Cancer. 2012;107:1220–6.CrossRefPubMedPubMedCentral
2.
go back to reference McPhail S, Elliss-Brookes L, Shelton J, Ives A, Greenslade M, Vernon S, et al. Emergency presentation of cancer and short-term mortality. Br J Cancer. 2013;109:2027–34.CrossRefPubMedPubMedCentral McPhail S, Elliss-Brookes L, Shelton J, Ives A, Greenslade M, Vernon S, et al. Emergency presentation of cancer and short-term mortality. Br J Cancer. 2013;109:2027–34.CrossRefPubMedPubMedCentral
3.
go back to reference Sheringham JR, Georghiou T, Chitnis XA, Bardsley M. Comparing primary and secondary health-care use between diagnostic routes before a colorectal cancer diagnosis: Cohort study using linked data. Br J Cancer. 2014;111:1490–9.CrossRefPubMedPubMedCentral Sheringham JR, Georghiou T, Chitnis XA, Bardsley M. Comparing primary and secondary health-care use between diagnostic routes before a colorectal cancer diagnosis: Cohort study using linked data. Br J Cancer. 2014;111:1490–9.CrossRefPubMedPubMedCentral
5.
go back to reference Tsang C, Bottle A, Majeed A, Aylin P. Cancer diagnosed by emergency admission in England: An observational study using the general practice research database. BMC Health Serv Res. 2013;13:308.CrossRefPubMedPubMedCentral Tsang C, Bottle A, Majeed A, Aylin P. Cancer diagnosed by emergency admission in England: An observational study using the general practice research database. BMC Health Serv Res. 2013;13:308.CrossRefPubMedPubMedCentral
7.
go back to reference Renzi C, Lyratzopoulos G, Card T, Chu TPC, Macleod U, Rachet B. Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms? A longitudinal data-linkage study in England. Br J Cancer. 2016;115:866–75.CrossRefPubMedPubMedCentral Renzi C, Lyratzopoulos G, Card T, Chu TPC, Macleod U, Rachet B. Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms? A longitudinal data-linkage study in England. Br J Cancer. 2016;115:866–75.CrossRefPubMedPubMedCentral
10.
go back to reference Thorn JC, Turner EL, Hounsome L, Walsh E, Down L, Verne J, et al. Validating the use of hospital episode statistics data and comparison of costing methodologies for economic evaluation: An end-of-life case study from the cluster randomised triAl of PSA testing for prostate cancer (CAP). BMJ Open. 2016;6:e011063.CrossRefPubMedPubMedCentral Thorn JC, Turner EL, Hounsome L, Walsh E, Down L, Verne J, et al. Validating the use of hospital episode statistics data and comparison of costing methodologies for economic evaluation: An end-of-life case study from the cluster randomised triAl of PSA testing for prostate cancer (CAP). BMJ Open. 2016;6:e011063.CrossRefPubMedPubMedCentral
11.
go back to reference DH & Frontier Economics. The likely impact of earlier diagnosis of cancer on costs and benefits to the NHS. 2011. DH & Frontier Economics. The likely impact of earlier diagnosis of cancer on costs and benefits to the NHS. 2011.
12.
go back to reference Brown ML, Riley GF, Schussler N, Etzioni R. Estimating health care costs related to cancer treatment from SEER-Medicare data. Med Care. 2002;40:IV–104.CrossRefPubMed Brown ML, Riley GF, Schussler N, Etzioni R. Estimating health care costs related to cancer treatment from SEER-Medicare data. Med Care. 2002;40:IV–104.CrossRefPubMed
13.
go back to reference Yabroff KR, Lamont EB, Mariotto A, Warren JL, Topor M, Meekins A, et al. Cost of Care for Elderly Cancer Patients in the United States. J Natl Cancer Inst. 2008;100:630–41.CrossRefPubMed Yabroff KR, Lamont EB, Mariotto A, Warren JL, Topor M, Meekins A, et al. Cost of Care for Elderly Cancer Patients in the United States. J Natl Cancer Inst. 2008;100:630–41.CrossRefPubMed
14.
go back to reference Basu A, Manning WG. Estimating lifetime or episode-of-illness costs under censoring. Health Econ. 2010;19:1010–28.CrossRefPubMed Basu A, Manning WG. Estimating lifetime or episode-of-illness costs under censoring. Health Econ. 2010;19:1010–28.CrossRefPubMed
15.
go back to reference Abdel-Rahman M, Stockton D, Rachet B, Hakulinen T, Coleman MP. What if cancer survival in Britain were the same as in Europe: How many deaths are avoidable? Br J Cancer. 2009;101:S115–24.CrossRefPubMedPubMedCentral Abdel-Rahman M, Stockton D, Rachet B, Hakulinen T, Coleman MP. What if cancer survival in Britain were the same as in Europe: How many deaths are avoidable? Br J Cancer. 2009;101:S115–24.CrossRefPubMedPubMedCentral
16.
go back to reference Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, et al. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): A multicentre randomised trial. Lancet. 2013;381:1194–202.CrossRefPubMed Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, et al. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): A multicentre randomised trial. Lancet. 2013;381:1194–202.CrossRefPubMed
19.
go back to reference Hinde S, McKenna C, Whyte S, Peake MD, Callister MEJ, Rogers T, et al. Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer. Br J Cancer. 2015;113:135–41.CrossRefPubMedPubMedCentral Hinde S, McKenna C, Whyte S, Peake MD, Callister MEJ, Rogers T, et al. Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer. Br J Cancer. 2015;113:135–41.CrossRefPubMedPubMedCentral
21.
go back to reference Bending MW, Trueman P, Lowson KV, Pilgrim H, Tappenden P, Chilcott J, et al. Estimating the direct costs of bowel cancer services provided by the National Health Service in England. Int J Technol Assess Health Care. 2010;26:362–9.CrossRefPubMed Bending MW, Trueman P, Lowson KV, Pilgrim H, Tappenden P, Chilcott J, et al. Estimating the direct costs of bowel cancer services provided by the National Health Service in England. Int J Technol Assess Health Care. 2010;26:362–9.CrossRefPubMed
22.
go back to reference Pilgrim H, Tappenden P, Chilcott J, Bending M, Trueman P, Shorthouse A, et al. The costs and benefits of bowel cancer service developments using discrete event simulation. J Oper Res Soc. 2009;60:1305–14.CrossRef Pilgrim H, Tappenden P, Chilcott J, Bending M, Trueman P, Shorthouse A, et al. The costs and benefits of bowel cancer service developments using discrete event simulation. J Oper Res Soc. 2009;60:1305–14.CrossRef
24.
go back to reference Luengo-Fernandez R, Leal J, Gray A, Sullivan R. Economic burden of cancer across the European Union: A population-based cost analysis. Lancet Oncol. 2013;14:1165–74.CrossRefPubMed Luengo-Fernandez R, Leal J, Gray A, Sullivan R. Economic burden of cancer across the European Union: A population-based cost analysis. Lancet Oncol. 2013;14:1165–74.CrossRefPubMed
25.
go back to reference Nuffield Trust. Use of health and social care by people with cancer. 2014. Nuffield Trust. Use of health and social care by people with cancer. 2014.
Metadata
Title
What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a population-based study
Authors
Mauro Laudicella
Brendan Walsh
Elaine Burns
Paolo Li Donni
Peter C. Smith
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4274-0

Other articles of this Issue 1/2018

BMC Cancer 1/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine