Published in:
Open Access
01-12-2018 | Case report
Re-challenging immune checkpoint inhibitor in a patient with advanced non-small cell lung cancer: a case report
Authors:
Taiki Hakozaki, Yusuke Okuma, Jumpei Kashima
Published in:
BMC Cancer
|
Issue 1/2018
Login to get access
Abstract
Background
Currently, immune checkpoint (ICP) inhibitors are essential drugs for the treatment of non-small cell lung cancer (NSCLC). However, in patients previously treated with ICP inhibitors, the efficacy and safety of re-challenging the same or another ICP inhibitor remain unclear.
Case presentation
We present the case of a patient treated with nivolumab for advanced NSCLC who was previously treated with an ICP inhibitor as the first-line chemotherapy along with heavy cytotoxic chemotherapy. After the failure of five lines of chemotherapy, 3 cycles of nivolumab, as the ICP inhibitor re-challenge, the patient achieved a partial response.
Conclusions
This case might suggest that re-challenging an ICP inhibitor could be clinically active in selected patients with advanced NSCLC who progress after achieving an initial clinical benefit with an ICP inhibitor.