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Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer

Authors: Jing-Jie Zhang, Hang Shu, Shuai-Shuai Hu, Yang Yu, Yi Sun, Yin Lv

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

To investigate the relationship between time elapsed since completion of radiotherapy (RT) and quality of life (QOL) of patients with breast cancer.

Methods

A total of 300 patients with breast cancer were treated at the First Affiliated Hospital of Anhui Medical University between January 2013 and April 2016. Of these, 212 patients were included in the study. Patients were divided into 4 groups based on the time elapsed since completion of RT. The generic cancer questionnaire, EORTC QLQ-30, and the breast cancer-specific questionnaire, QLQ-BR23, were used to assess the QOL.

Results

Analysis of time elapsed since completion of RT and QOL revealed changes in the scores for role function with passage of time; the third year’s scores were the highest. Pain symptoms during the 3rd and 4th years after RT were lower than those during the 1st and 2nd years after RT; scores for financial difficulties fluctuated with passage of time; perception of own body scores improved within first 3 years; sexual activity and enjoyment of sexual activity showed a significant decrease during the 2nd to 4th year post RT. Scores pertaining to concerns about future state of health showed a significant increase during the 2nd to 4th year after RT, while breast symptoms score showed fluctuations with passage of time.

Conclusions

Social function, pain symptoms, and concerns about future state of health tended to improve with passage of time after RT. Other scales showed no correlation with time elapsed since completion of RT.
Literature
2.
go back to reference Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.CrossRefPubMed Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.CrossRefPubMed
3.
go back to reference DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64:52–62.CrossRefPubMed DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64:52–62.CrossRefPubMed
4.
go back to reference Krotneva S, Reidel K, Nassif M, Trabulsi N, Mayo N, Tamblyn R, et al. Rates and predictors of consideration for adjuvant radiotherapy among high-risk breast cancer patients: a cohort study. Breast Cancer Res Treat. 2013;140:397–405.CrossRefPubMedPubMedCentral Krotneva S, Reidel K, Nassif M, Trabulsi N, Mayo N, Tamblyn R, et al. Rates and predictors of consideration for adjuvant radiotherapy among high-risk breast cancer patients: a cohort study. Breast Cancer Res Treat. 2013;140:397–405.CrossRefPubMedPubMedCentral
5.
go back to reference Ness KK, Wall MM, Oakes JM, Robison LL, Gurney JG. Physical performance limitations and participation restrictions among cancer survivors: a population-based study. Ann Epidemiol. 2006;16:197–205.CrossRefPubMed Ness KK, Wall MM, Oakes JM, Robison LL, Gurney JG. Physical performance limitations and participation restrictions among cancer survivors: a population-based study. Ann Epidemiol. 2006;16:197–205.CrossRefPubMed
6.
go back to reference Mejdahl MK, Andersen KG, Gartner R, Kroman N, Kehlet H. Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study. BMJ. 2013;346:f1865.CrossRefPubMed Mejdahl MK, Andersen KG, Gartner R, Kroman N, Kehlet H. Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study. BMJ. 2013;346:f1865.CrossRefPubMed
7.
go back to reference Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM. Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer. 2010;116:5138–49.CrossRefPubMed Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM. Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer. 2010;116:5138–49.CrossRefPubMed
8.
go back to reference Levangie PK, Drouin J. Magnitude of late effects of breast cancer treatments on shoulder function: a systematic review. Breast Cancer Res Treat. 2009;116:1–15.CrossRefPubMed Levangie PK, Drouin J. Magnitude of late effects of breast cancer treatments on shoulder function: a systematic review. Breast Cancer Res Treat. 2009;116:1–15.CrossRefPubMed
10.
go back to reference Dawes DJ, Meterissian S, Goldberg M, Mayo NE. Impact of lymphoedema on arm function and health-related quality of life in women following breast cancer surgery. J Rehabil Med. 2008;40:651–8.CrossRefPubMed Dawes DJ, Meterissian S, Goldberg M, Mayo NE. Impact of lymphoedema on arm function and health-related quality of life in women following breast cancer surgery. J Rehabil Med. 2008;40:651–8.CrossRefPubMed
11.
go back to reference Brach M, et al. ICF Core Sets for breast cancer. J Rehabil Med. 2004(44 Suppl):121-7. Brach M, et al. ICF Core Sets for breast cancer. J Rehabil Med. 2004(44 Suppl):121-7.
12.
go back to reference Brockow T, et al. Identifying the concepts contained in outcome measures of clinical trials on breast cancer using the international classification of functioning, disability and health as a reference. J Rehabil Med. 2004;36:43–8.CrossRef Brockow T, et al. Identifying the concepts contained in outcome measures of clinical trials on breast cancer using the international classification of functioning, disability and health as a reference. J Rehabil Med. 2004;36:43–8.CrossRef
13.
go back to reference Alfano CM, Smith AW, Irwin ML, Bowen DJ, Sorensen B, Reeve BB, et al. Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis. J Cancer Surviv. 2007;1:116–28.CrossRefPubMedPubMedCentral Alfano CM, Smith AW, Irwin ML, Bowen DJ, Sorensen B, Reeve BB, et al. Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis. J Cancer Surviv. 2007;1:116–28.CrossRefPubMedPubMedCentral
14.
go back to reference Gilchrist LS, Galantino ML, Wampler M, Marchese VG, Morris GS, Ness KK. A framework for assessment in oncology rehabilitation. Phys Ther. 2009;89:286–306.CrossRefPubMedPubMedCentral Gilchrist LS, Galantino ML, Wampler M, Marchese VG, Morris GS, Ness KK. A framework for assessment in oncology rehabilitation. Phys Ther. 2009;89:286–306.CrossRefPubMedPubMedCentral
15.
go back to reference Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.CrossRefPubMed Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.CrossRefPubMed
16.
go back to reference Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996;14:2756–68.CrossRefPubMed Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996;14:2756–68.CrossRefPubMed
17.
go back to reference Montazeri A. Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. J Exp Clin Cancer Res. 2008;27:32.CrossRefPubMedPubMedCentral Montazeri A. Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. J Exp Clin Cancer Res. 2008;27:32.CrossRefPubMedPubMedCentral
18.
go back to reference Chiou CJ, Chang HY, Chen IP, Wang HH. Social support and caregiving circumstances as predictors of caregiver burden in Taiwan. Arch Gerontol Geriatr. 2009;48:419–24.CrossRefPubMed Chiou CJ, Chang HY, Chen IP, Wang HH. Social support and caregiving circumstances as predictors of caregiver burden in Taiwan. Arch Gerontol Geriatr. 2009;48:419–24.CrossRefPubMed
19.
go back to reference Rim CH, Ahn SJ, Kim JH, Yoon WS, Chun M, Yang DS, et al. An assessment of quality of life for early phase after adjuvant radiotherapy in breast cancer survivors: a Korean multicenter survey (KROG 14-09). Health Qual Life Outcomes. 2017;15:96.CrossRefPubMedPubMedCentral Rim CH, Ahn SJ, Kim JH, Yoon WS, Chun M, Yang DS, et al. An assessment of quality of life for early phase after adjuvant radiotherapy in breast cancer survivors: a Korean multicenter survey (KROG 14-09). Health Qual Life Outcomes. 2017;15:96.CrossRefPubMedPubMedCentral
20.
go back to reference Sharma N, Purkayastha A. Impact of radiotherapy on psychological, financial, and sexual aspects in Postmastectomy carcinoma breast patients: a prospective study and management. Asia Pac J Oncol Nurs. 2017;4:69–76.CrossRefPubMedPubMedCentral Sharma N, Purkayastha A. Impact of radiotherapy on psychological, financial, and sexual aspects in Postmastectomy carcinoma breast patients: a prospective study and management. Asia Pac J Oncol Nurs. 2017;4:69–76.CrossRefPubMedPubMedCentral
21.
go back to reference Fantoni SQ, Peugniez C, Duhamel A, Skrzypczak J, Frimat P, Leroyer A. Factors related to return to work by women with breast cancer in northern France. J Occup Rehabil. 2010;20:49–58.CrossRefPubMed Fantoni SQ, Peugniez C, Duhamel A, Skrzypczak J, Frimat P, Leroyer A. Factors related to return to work by women with breast cancer in northern France. J Occup Rehabil. 2010;20:49–58.CrossRefPubMed
22.
go back to reference Pehlivan S, Kuzhan A, Yildirim Y, Fadiloglu C. Comfort and quality of life in patients with breast cancer undergoing radiation therapy. J BUON. 2016;21:549–55.PubMed Pehlivan S, Kuzhan A, Yildirim Y, Fadiloglu C. Comfort and quality of life in patients with breast cancer undergoing radiation therapy. J BUON. 2016;21:549–55.PubMed
23.
go back to reference Xiao C, Miller AH, Felger J, Mister D, Liu T, Torres MA. A prospective study of quality of life in breast cancer patients undergoing radiation therapy. Adv Radiat Oncol. 2016;1:10–6.CrossRefPubMedPubMedCentral Xiao C, Miller AH, Felger J, Mister D, Liu T, Torres MA. A prospective study of quality of life in breast cancer patients undergoing radiation therapy. Adv Radiat Oncol. 2016;1:10–6.CrossRefPubMedPubMedCentral
24.
go back to reference Hofso K, Bjordal K, Diep LM, Rustoen T. The relationships between demographic and clinical characteristics and quality of life during and after radiotherapy: in women with breast cancer. Qual Life Res. 2014;23:2769–77.CrossRefPubMed Hofso K, Bjordal K, Diep LM, Rustoen T. The relationships between demographic and clinical characteristics and quality of life during and after radiotherapy: in women with breast cancer. Qual Life Res. 2014;23:2769–77.CrossRefPubMed
25.
go back to reference Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302:1985–92.CrossRefPubMed Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302:1985–92.CrossRefPubMed
26.
go back to reference Hopwood P, Haviland JS, Sumo G, Mills J, Bliss JM, Yarnold JR, et al. Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised standardisation of breast radiotherapy (START) trials. Lancet Oncol. 2010;11:231–40.CrossRefPubMed Hopwood P, Haviland JS, Sumo G, Mills J, Bliss JM, Yarnold JR, et al. Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised standardisation of breast radiotherapy (START) trials. Lancet Oncol. 2010;11:231–40.CrossRefPubMed
27.
go back to reference Krishnan L, Stanton AL, Collins CA, Liston VE, Jewell WR. Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy. Cancer. 2001;91:2282–7.CrossRefPubMed Krishnan L, Stanton AL, Collins CA, Liston VE, Jewell WR. Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy. Cancer. 2001;91:2282–7.CrossRefPubMed
28.
go back to reference Peintinger F, Reitsamer R, Stranzl H, Ralph G. Comparison of quality of life and arm complaints after axillary lymph node dissection vs sentinel lymph node biopsy in breast cancer patients. Br J Cancer. 2003;89:648–52.CrossRefPubMedPubMedCentral Peintinger F, Reitsamer R, Stranzl H, Ralph G. Comparison of quality of life and arm complaints after axillary lymph node dissection vs sentinel lymph node biopsy in breast cancer patients. Br J Cancer. 2003;89:648–52.CrossRefPubMedPubMedCentral
29.
go back to reference Johnsson A, Fornander T, Rutqvist LE, Olsson M. Work status and life changes in the first year after breast cancer diagnosis. Work. 2011;38:337–46.PubMed Johnsson A, Fornander T, Rutqvist LE, Olsson M. Work status and life changes in the first year after breast cancer diagnosis. Work. 2011;38:337–46.PubMed
30.
go back to reference Casellas-Grau A, Ochoa C, Ruini C. Psychological and clinical correlates of posttraumatic growth in cancer: A systematic and critical review. Psycho-Oncology. 2017;26(12):2007–18.CrossRefPubMed Casellas-Grau A, Ochoa C, Ruini C. Psychological and clinical correlates of posttraumatic growth in cancer: A systematic and critical review. Psycho-Oncology. 2017;26(12):2007–18.CrossRefPubMed
Metadata
Title
Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer
Authors
Jing-Jie Zhang
Hang Shu
Shuai-Shuai Hu
Yang Yu
Yi Sun
Yin Lv
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4207-y

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