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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

HtrA1 as a promising tissue marker in cancer: a meta-analysis

Authors: Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni, Valerio Filippo Profeta

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was performed: to compare HtrA1 expression as mRNA and protein, in cancer tissue versus non-cancer tissue and to assess overall survival in relation to low or medium-high HtrA1 tissue expression.

Methods

The PRISMA method was used for study selection. OR and HR with 95% confidence interval was used as a measure of effect size as appropriate. A random-effects model was applied to account for different sources of variation among studies. Heterogeneity across studies was assessed using Q statistic. Sensitivity analysis was conducted to check the stability of study findings. Egger’s regression method was applied to test funnel plot asymmetry.

Results

Sensitivity analysis indicated the stability of meta-analytic findings in each meta-analysis. The study found a significantly different HtrA1 expression in cancer and non-cancer tissue. The meta-analysis of the prognostic studies showed a different survival according to HtrA1 expression.

Conclusions

The present data may provide a contribution to future work directed at exploring the role of HtrA1 in tumor development and progression and at establishing whether it may be used as a promising tissue marker for some tumors.
Appendix
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Metadata
Title
HtrA1 as a promising tissue marker in cancer: a meta-analysis
Authors
Emma Altobelli
Paolo Matteo Angeletti
Manrico Morroni
Valerio Filippo Profeta
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4041-2

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