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BMC Cancer

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Open Access 01-12-2017 | Research article

High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study

Authors: Alexandra Vulcan, Jonas Manjer, Bodil Ohlsson

Published in: BMC Cancer | Issue 1/2017

Abstract

Background

High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin resistance (HOMA2-IR), respectively, and to determine whether these associations were dependent on sex and cancer site.

Methods

The Malmö Diet and Cancer cardiovascular cohort comprises 6103 individuals. During 81,781 person-years of follow-up, 145 cases of CRC were identified. The hazard ratio of measured blood glucose and plasma insulin and calculated HOMA2-IR were estimated with Cox proportional hazard regression.

Results

An association was found between high levels of blood glucose and risk of CRC (HR: 1.72 for the highest compared with the lowest quartile; 95% CI: 1.05, 2.84; p_trend = 0.044), and colon cancer (HR: 1.70 for the highest compared with the lowest quartile; 95% CI: 0.87, 3.33; p_trend = 0.032). In men, an association was found between blood glucose and CRC (HR: 2.80 for the highest compared with the lowest quartile; 95% CI: 1.37, 5.70; p_trend = 0.001), and colon cancer (HR: 4.48 for the highest compared with the lowest quartile; 95% CI: 1.27, 15.84; p_trend = 0.007), but this was not found in women. No associations between plasma insulin, or HOMA2-IR, and CRC, were found.

Conclusion

High levels of blood glucose in men are associated with risk of colon cancer. The findings contribute to facilitating to identify those most in need of prevention and screening.

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Title: High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study
Authors: Alexandra Vulcan
Jonas Manjer
Bodil Ohlsson
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-017-3874-4

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