Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2017

Open Access 01-12-2017 | Research article

A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

Authors: Lina Zhang, Ling Zhuang, Chang Shi, Yanwei Miao, Weisheng Zhang, Qingwei Song, Jianyun Kang, Zhijin Lang, Xuegang Xin, Ailian Liu, Jiani Hu

Published in: BMC Cancer | Issue 1/2017

Login to get access

Abstract

Background

Solid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we report our findings on this new category of papillary carcinoma to fill the gap in MRI characterization of SPC.

Methods

This retrospective study included four pathology-confirmed in situ SPC patients. Conventional MRI, diffusion weighted imaging (DWI), and magnetic resonance spectroscopy (MRS) were performed with a 1.5 T whole-body MR scanner before surgical operation. The following characteristics of each lesion were recorded: signal intensity on T2WI/STIR and T1FSPGR, morphology, maximum lesion size, and time intensity curve (TIC) on dynamic contrast enhancement MRI (DCE-MRI), apparent diffusion coefficient (ADC) value from DWI, and Cho peak from MRS.

Results

Signal intensities of all lesions were heterogenous on T2WI/STIR and T1FSPGR. Mass enhancements were observed for all lesions with either oval or irregular shapes on DCE-MRI. The maximum lesion size ranged from 0.8 cm to 3.2 cm. All lesion margins were circumscribed, and internal enhancements were homogeneous or heterogeneous from DCE-MRI. TIC appeared with a rapid increase in initial contrast phases of all lesions. All lesions on DWI (b = 1000s/mm2) were slightly hyperintense with an ADC value range of 1.3 × 10−3 mm2/s to 1.9 × 10−3 mm2/s. Cho peak was absent at 3.2 ppm for all lesions.

Conclusions

MRI characteristics of SPC include heterogeneous signal intensity within the lesion on T2WI/STIR and T1FSPGR, mass enhancement with circumscribed margins, either oval or irregular shapes, and a rapid initial enhancement of TIC on DCE-MRI. ADC values and the absence of Cho peak may provide valuable information to distinguish SPC from other invasive breast carcinomas.
Literature
1.
Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2015;66:761–70.CrossRefPubMed
2.
Duprez R, Wilkerson PM, Lacroix-Triki M, Lambros MB, Mackay A, Hern RA, et al. Immunophenotypic and genomic characterization of papillary carcinomas of the breast. J Pathol. 2012;226:427–41.CrossRefPubMed
3.
Yang WT, Zhu XZ. The introduction of 2012 WHO classification of tumours of the breast. Zhonghua Bing Li Xue Za Zhi. 2013;42:78–80.PubMed
4.
Pal SK, Lau SK, Kruper L, Nwoye U, Garberoglio C, Gupta RK, et al. Papillary Carcinoma of the Breast: An Overview. Breast Cancer Res Treat. 2010;122:637–45.CrossRefPubMedPubMedCentral
5.
Eiada R, Chong J, Kulkarni S, Goldberg F, Muradali D. Papillary lesions of the breast: MRI, ultrasound, and mammographic appearances. AJR Am J Roentgenol. 2012;198:264–71.CrossRefPubMed
6.
Sarica O, Uluc F, Tasmali D. Magnetic resonance imaging features of papillary breast lesions. Eur J Radiol. 2014;83:524–30.CrossRefPubMed
7.
Tominaga J, Hama H, Kimura N, Takahashi S. Magnetic resonance imaging of intraductal papillomas of the breast. J Comput Assist Tomogr. 2011;35:153–7.CrossRefPubMed
8.
Leena JB, Kini RG, Amber S. Invasive (solid) papillary carcinoma of the breast: a report of two cases. J Clin Diagn Res. 2013;7:1150–1.
9.
Yoshimura N, Murakami S, Kaneko M, Sakatani A, Hirabayashi N, Takiyama W. Synchronous bilateral solid papillary carcinomas of the breast. Case Rep Surg. 2013;812129. doi:10.​1155/​2013/​812129.
10.
Yeung DK, Cheung HS, Tse GM. Human breast lesions: characterization with contrast enhanced in vivo proton MR spectroscopy initial results. Radiology. 2001;220:40–6.CrossRefPubMed
11.
Hatakenaka M, Soeda H, Yabuuchi H, Matsuo Y, Kamitani T, Oda Y, et al. Apparent diffusion coefficients of breast tumors: clinical application. Magn Reson Med Sci. 2008;7:23–9.CrossRefPubMed
12.
Linda A, Londero V, Mazzarella F, Zuiani C, Bazzocchi M. Rare breast neoplasms: is there any peculiar feature on magnetic resonance mammography? La Radiol Med. 2007;112:850–62.CrossRef
13.
Lorenzon M, Zuiani C, Linda A, Londero V, Girometti R, Bazzocchi M. Magnetic resonance imaging in patients with nipple discharge: should we recommend it? Eur Radiol. 2011;21:899–907.CrossRefPubMed
14.
Yili Z, Xiaoyan H, Hongwen D, Yun Z, Xin C, Peng W, et al. The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma. BMC Cancer. 2009;9:18–27.CrossRefPubMedPubMedCentral
15.
Kinoshita T, Yashiro N, Ihara N, Funatu H, Fukuma E, Narita M. Diffusion-weighted half-Fourier single-shot turbo spin echo imaging in breast tumors: differentiation of invasive ductal carcinoma from fibroadenoma. J Comput Assist Tomogr. 2002;26:1042–6.CrossRefPubMed
16.
Woodhams R, Kakita S, Hata H, Iwabuchi K, Umeoka S, Mountford CE, et al. Diffusion-weighted imaging of mucinous carcinoma of the breast: Evaluation of apparent diffusion coefficient and signal intensity in correlation with histologic findings. AJR Am J Roentgenol. 2009;193:260–6.CrossRefPubMed
17.
Peter S, Laurence G, David C, Boguslaw T, Luke B, Bruno G, et al. Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T. Eur Radiol. 2005;15:1037–43.CrossRef
18.
Suppiah S, Rahmat K, Mohd-Shah MN, Azlan CA, Tan LK, Aziz YF, et al. Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI. Clin Radiol. 2013;68:e502–10.CrossRefPubMed
19.
Yeung DK, Yang WT, Tse GM. Breast cancer: in vivo proton MR spectroscopy in the characterization of histopathologic subtypes and preliminary observations in axillary node metastases. Radiology. 2002;225:190–7.CrossRefPubMed
20.
Saremian J, Rosa M. Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor. Arch Pathol Lab Med. 2012;136:1308–11.CrossRefPubMed
21.
Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, et al. Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int. 2007;57:421–9.CrossRefPubMed
22.
Cui X, Wei S. Composite encapsulated papillary carcinoma and solid papillary carcinoma. Pathol Int. 2015;65:133–7.CrossRefPubMed
Metadata
Title
A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients
Authors
Lina Zhang
Ling Zhuang
Chang Shi
Yanwei Miao
Weisheng Zhang
Qingwei Song
Jianyun Kang
Zhijin Lang
Xuegang Xin
Ailian Liu
Jiani Hu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-017-3518-8

Other articles of this Issue 1/2017

BMC Cancer 1/2017 Go to the issue

Study protocol

Cerebellar mutism syndrome in children with brain tumours of the posterior fossa

Research article

Oligometastases from prostate cancer: local treatment with stereotactic body radiotherapy (SBRT)

Research article

Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients

Research article

Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis

Research article

Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

Research article

Incidence of breast cancer in Chinese women exposed to the 1959–1961 great Chinese famine
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits