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BMC Cancer
Published in: BMC Cancer 1/2017

Open Access 01-12-2017 | Research article

What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

Authors: Ricardo G. Becker, Lauro J. Gregianin, Carlos R. Galia, Reynaldo Jesus-Garcia Filho, Eduardo A. Toller, Gerardo Badell, Suely A. Nakagawa, Alexandre David, André M. Baptista, Eduardo S. Yonamime, Osvaldo A. Serafini, Valter Penna, Julie Francine C. Santos, Algemir L. Brunetto, On behalf of the Brazilian Collaborative Study Group of Ewing Family of Tumors – EWING1 and the Brazilian Society of Pediatric Oncology – SOBOPE

Published in: BMC Cancer | Issue 1/2017

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Abstract

Background

Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1).

Methods

Seventy-three patients with localized Ewing sarcoma of bone aged < 30 years were included. The treating physicians defined the modality of local control based on the recommendations of the coordinating center and the patient and tumor characteristics. Possible associations of local control modality with local failure (LF), disease-free survival (DFS), event-free survival (EFS), overall survival (OS), and clinical characteristics were analyzed.

Results

Mean patient age was 12.8 years (range, 2 to 25 years) and median follow-up time was 4.5 years (range, 2.3 to 6.7 years). Forty-seven patients underwent surgery, 13 received radiotherapy, and 13 received both. The 5-year EFS, OS, and DFS for all patients was 62.1%, 63.3%, and 73.1%, respectively. The 5-year cumulative incidence (CI) of LF was 7.6% for surgery, 11.1% for radiotherapy, and 0% for postoperative radiotherapy (PORT) (p = 0.61). The 5-year EFS was 71.7% for surgery, 30.8% for radiotherapy, and 64.1% for PORT (p = 0.009).

Conclusions

There was a significant effect of local control modality on EFS and OS in the study. Surgery and PORT modalities yielded very close results. The group treated with radiotherapy alone had considerably worse outcomes. This may be confounded by greater risk factors in these patients. There was no significant effect of local control modality on the CI of LF and DFS.
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Metadata
Title
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1
Authors
Ricardo G. Becker
Lauro J. Gregianin
Carlos R. Galia
Reynaldo Jesus-Garcia Filho
Eduardo A. Toller
Gerardo Badell
Suely A. Nakagawa
Alexandre David
André M. Baptista
Eduardo S. Yonamime
Osvaldo A. Serafini
Valter Penna
Julie Francine C. Santos
Algemir L. Brunetto
On behalf of the Brazilian Collaborative Study Group of Ewing Family of Tumors – EWING1 and the Brazilian Society of Pediatric Oncology – SOBOPE
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-017-3391-5

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