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BMC Cancer
Published in: BMC Cancer 1/2017

Open Access 01-12-2017 | Research article

Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

Authors: Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O’Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres, Gustavo Victoriano Sierra González

Published in: BMC Cancer | Issue 1/2017

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Abstract

Background

Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetics, which can be relevant to understand cancer genesis and select the most suitable treatment.

Methods

The classical Kolmogorov-Johnson-Mehl-Avrami as well as the modified Kolmogorov-Johnson-Mehl-Avrami models to describe unperturbed fibrosarcoma Sa-37 tumor growth are used and compared with the Gompertz modified and Logistic models. Viable tumor cells (1×105) are inoculated to 28 BALB/c male mice.

Results

Modified Gompertz, Logistic, Kolmogorov-Johnson-Mehl-Avrami classical and modified Kolmogorov-Johnson-Mehl-Avrami models fit well to the experimental data and agree with one another. A jump in the time behaviors of the instantaneous slopes of classical and modified Kolmogorov-Johnson-Mehl-Avrami models and high values of these instantaneous slopes at very early stages of tumor growth kinetics are observed.

Conclusions

The modified Kolmogorov-Johnson-Mehl-Avrami equation can be used to describe unperturbed fibrosarcoma Sa-37 tumor growth. It reveals that diffusion-controlled nucleation/growth and impingement mechanisms are involved in tumor growth kinetics. On the other hand, tumor development kinetics reveals dynamical structural transformations rather than a pure growth curve. Tumor fractal property prevails during entire TGK.
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Metadata
Title
Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?
Authors
Maraelys Morales González
Javier Antonio González Joa
Luis Enrique Bergues Cabrales
Ana Elisa Bergues Pupo
Baruch Schneider
Suleyman Kondakci
Héctor Manuel Camué Ciria
Juan Bory Reyes
Manuel Verdecia Jarque
Miguel Angel O’Farril Mateus
Tamara Rubio González
Soraida Candida Acosta Brooks
José Luis Hernández Cáceres
Gustavo Victoriano Sierra González
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2017
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-017-3159-y

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