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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Authors: Olaf Schoffer, Stefanie Schülein, Gerlinde Arand, Hans Arnholdt, Dieter Baaske, Ralf C. Bargou, Nikolaus Becker, Matthias W. Beckmann, Yves Bodack, Beatrix Böhme, Tayfun Bozkurt, Regine Breitsprecher, Andre Buchali, Elke Burger, Ulrike Burger, Klaus Dommisch, Gudrun Elsner, Karin Fernschild, Ulrike Flintzer, Uwe Funke, Michael Gerken, Hubert Göbel, Norbert Grobe, Vera Gumpp, Lucie Heinzerling, Lana Raffaela Kempfer, Alexander Kiani, Monika Klinkhammer-Schalke, Sabine Klöcking, Ute Kreibich, Katrin Knabner, Peter Kuhn, Stine Lutze, Uwe Mäder, Tanja Maisel, Jan Maschke, Martin Middeke, Andreas Neubauer, Antje Niedostatek, Anabelle Opazo-Saez, Christoph Peters, Beatrice Schell, Gerhard Schenkirsch, Harald Schmalenberg, Peter Schmidt, Constanze Schneider, Birgit Schubotz, Anika Seide, Paul Strecker, Sabine Taubenheim, Matthias Wackes, Steffen Weiß, Claudia Welke, Carmen Werner, Christian Wittekind, Jörg Wulff, Heike Zettl, Stefanie J. Klug

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients.

Methods

Pooled data from 61 895 malignant melanoma patients diagnosed between 2002 and 2011 and documented in 28 German population-based and hospital-based clinical cancer registries were analysed using descriptive methods, joinpoint regression, logistic regression and relative survival.

Results

The number of annually documented cases increased by 53.2% between 2002 (N = 4 779) and 2011 (N = 7 320). There was a statistically significant continuous positive trend in the proportion of stage UICC I cases diagnosed between 2002 and 2011, compared to a negative trend for stage UICC II. No trends were found for stages UICC III and IV respectively. Age (OR 0.97, 95% CI 0.97–0.97), sex (OR 1.18, 95% CI 1.11–1.25), date of diagnosis (OR 1.05, 95% CI 1.04–1.06), ‘diagnosis during screening’ (OR 3.24, 95% CI 2.50–4.19) and place of residence (OR 1.23, 95% CI 1.16–1.30) had a statistically significant influence on the tumour stage at diagnosis. The overall 5-year relative survival for invasive cases was 83.4% (95% CI 82.8–83.9%).

Conclusions

No distinct changes in the distribution of malignant melanoma tumour stages among those aged 35 and older were seen that could be directly attributed to the introduction of skin cancer screening in 2008.
Appendix
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Metadata
Title
Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011
Authors
Olaf Schoffer
Stefanie Schülein
Gerlinde Arand
Hans Arnholdt
Dieter Baaske
Ralf C. Bargou
Nikolaus Becker
Matthias W. Beckmann
Yves Bodack
Beatrix Böhme
Tayfun Bozkurt
Regine Breitsprecher
Andre Buchali
Elke Burger
Ulrike Burger
Klaus Dommisch
Gudrun Elsner
Karin Fernschild
Ulrike Flintzer
Uwe Funke
Michael Gerken
Hubert Göbel
Norbert Grobe
Vera Gumpp
Lucie Heinzerling
Lana Raffaela Kempfer
Alexander Kiani
Monika Klinkhammer-Schalke
Sabine Klöcking
Ute Kreibich
Katrin Knabner
Peter Kuhn
Stine Lutze
Uwe Mäder
Tanja Maisel
Jan Maschke
Martin Middeke
Andreas Neubauer
Antje Niedostatek
Anabelle Opazo-Saez
Christoph Peters
Beatrice Schell
Gerhard Schenkirsch
Harald Schmalenberg
Peter Schmidt
Constanze Schneider
Birgit Schubotz
Anika Seide
Paul Strecker
Sabine Taubenheim
Matthias Wackes
Steffen Weiß
Claudia Welke
Carmen Werner
Christian Wittekind
Jörg Wulff
Heike Zettl
Stefanie J. Klug
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2963-0

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