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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Case report

Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report

Authors: Yang-Yang Shen, Hong-Wei Qin, Jian-Bo Zhang, Zhen-Dan Wang, Pang Li, Kai Pang, Bo Zhang, Sheng Li, Kai Cui

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.

Case presentation

We performed an analysis of a 66-year-old male patient’s case history, as well as conventional pathological analysis and Raman spectroscopic detection of the diaphragmatic tumor. We also analyzed the underlying causes of this condition to prevent complications and reduce misdiagnoses in future cases. The patient had a history of peritoneal fluorouracil implantation. Pathological analysis of the diaphragmatic mass revealed foreign particles, and Raman detection showed that the mass contained fluorouracil.

Conclusion

Fluorouracil implants may persist due to the high concentrations of this drug used in peritoneal chemotherapy. This finding should provide guidance and improve the application of peritoneal implants. In clinical trials, and the diagnosis of liver metastasis should be based on pathological results.
Literature
1.
Engelhard HH. The role of interstitial BCNU chemotherapy in the treatment of malignant glioma. Surg Neurol. 2000;53(5):458–64. PMID: 10874145.CrossRefPubMed
2.
Cai SJ, Wang Q, et al. Expert consensus within the extended- release specifications fluorouracil intraperitoneal chemotherapy in colorectal cancer surgery. J Gen Surg. 2011;26(6):533–5 (In Chinese).
3.
Liu H, Cui J, Jiang N, et al. Clinical observation of abdominal regional fluorouracil implants in advanced gastric cancer patients during operation. Zhonghua Wei Chang Wai Ke Za Zhi. 2014;17(7):694–7. Chinese. [PMID: 25070451].PubMed
4.
Huang Y, Nie YL, Zhang MM, et al. Fluorouracil implants for colorectal cancer: a systematic review and meta-analysis. Zhonghua Wei Chang Wai Ke Za Zhi. 2012;15(4):377–81. Chinese. [PMID: 22539386].PubMed
5.
Wang N, Chen L, Wei B, et al. Effect of delayed-release 5-fluorouracil implants on colorectal cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 2010;13(1):57–9. Chinese. [PMID: 20099164].PubMed
6.
Kehoe SM, Williams NL, Yakubu R, et al. Incidence of intestinal obstruction following intraperitoneal chemotherapy for ovarian tubal and peritoneal malignancies. Gynecol Oncol. 2009;113(2):228–32. PMID: 19254808.CrossRefPubMed
7.
An HJ, Feng M, et al. Efficacy of percutaneous implantation of tumor implants fluorouracil treatment of liver cancer. Cancer Prog. 2010;8(2):198–201. Chinese.
8.
Xiao J, Lin Y, et al. Resection of colorectal cancer in the safety and efficacy of sustained-release implants fluorouracil meta-analysis. J Gen Surg. 2011;26(4):358–9. Chinese.
9.
Hayes DF, Bast RC, Desch CE, et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst. 1996;88:1456–66. PMID: 8841020.CrossRefPubMed
10.
Kim SW, Kim SW, Song SK, et al. Gastric pseudotumoral lesion caused by a fish bone mimicking a gastric submucosal tumor. J Gastric Cancer. 2014;14(3):204–6. PMID: 25328766.CrossRefPubMedPubMedCentral
11.
Cheon JW, Kim EY, Kim KY, et al. A case of gossypiboma masquerading as a gastrointestinal stromal tumor. Clin Endosc. 2011;44(1):51–4. PMID: 22741113.CrossRefPubMedPubMedCentral
12.
Jiao Y, Shang Y, Li Q, et al. Foreign body granulomas in the left main bronchus resulting from the sutures for esophageal cancer surgery: the report of two cases. Chin Med J (Engl). 2012;125(15):2764–7 [PMID: 22931989].
13.
Junghans R, Schumann U, Finn H, et al. Foreign body granuloma of the head of the pancreas caused by a fish bone- a rare differential diagnosis in head of the pancreas tumor. Chirurg. 1999;70(12):1489–91. German. [PMID: 10637708].CrossRefPubMed
14.
Böhmer R. Regression of an inflammatory abdominal tumor after endoscopic removal of a foreign body. Z Gastroenterol. 1983;21(2):85–8. German. [PMID: 6342283].PubMed
15.
Guo XX, Yang J, et al. Clinical drug fluorouracil way analysis of implants. J Pharmacoepidemiol. 2010;19(8):441–2. Chinese.
16.
Bai DS, Jin SJ, He R, et al. Granuloma induced by sustained-release fluorouracil implants misdiagnosed as a hepatic tumor: A case report. Oncol Lett. 2014;8(2):742–4. PMID:25013494.PubMedPubMedCentral
17.
Zhang GQ. Experimental study on the safety of administration of rat peritoneal implants release agent fluorouracil. J Clin Oncol. 2011;16(7):586–92. Chinese.
Metadata
Title
Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report
Authors
Yang-Yang Shen
Hong-Wei Qin
Jian-Bo Zhang
Zhen-Dan Wang
Pang Li
Kai Pang
Bo Zhang
Sheng Li
Kai Cui
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2778-z

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