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BMC Cancer
Published in: BMC Cancer 2/2016

Open Access 01-09-2016 | Review

In vitro models of cancer stem cells and clinical applications

Authors: Sara S. Franco, Karolina Szczesna, Maria S. Iliou, Mohammed Al-Qahtani, Ali Mobasheri, Julianna Kobolák, András Dinnyés

Published in: BMC Cancer | Special Issue 2/2016

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Abstract

Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the current non-surgical treatments can cure cancer effectively. The reason could be due to the subpopulation called “cancer stem cells” (CSCs), being defined as those cells within a tumour that have properties of stem cells: self-renewal and the ability for differentiation into multiple cell types that occur in tumours.
The phenomenon of CSCs is based on their resistance to many of the current cancer therapies, which results in tumour relapse. Although further investigation regarding CSCs is still needed, there is already evidence that these cells may play an important role in the prognosis of cancer, progression and therapeutic strategy. Therefore, long-term patient survival may depend on the elimination of CSCs. Consequently, isolation of pure CSC populations or reprogramming of cancer cells into CSCs, from cancer cell lines or primary tumours, would be a useful tool to gain an in-depth knowledge about heterogeneity and plasticity of CSC phenotypes and therefore carcinogenesis. Herein, we will discuss current CSC models, methods used to characterize CSCs, candidate markers, characteristic signalling pathways and clinical applications of CSCs. Some examples of CSC-specific treatments that are currently in early clinical phases will also be presented in this review.
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Metadata
Title
In vitro models of cancer stem cells and clinical applications
Authors
Sara S. Franco
Karolina Szczesna
Maria S. Iliou
Mohammed Al-Qahtani
Ali Mobasheri
Julianna Kobolák
András Dinnyés
Publication date
01-09-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue Special Issue 2/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2774-3
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
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