Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Nurse-led group consultation intervention reduces depressive symptoms in men with localised prostate cancer: a cluster randomised controlled trial

Authors: Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda

Published in: BMC Cancer | Issue 1/2016

Login to get access

Abstract

Background

Radiotherapy for localised prostate cancer has many known and distressing side effects. The efficacy of group interventions for reducing psychological morbidity is lacking. This study investigated the relative benefits of a group nurse-led intervention on psychological morbidity, unmet needs, treatment-related concerns and prostate cancer-specific quality of life in men receiving curative intent radiotherapy for prostate cancer.

Methods

This phase III, two-arm cluster randomised controlled trial included 331 men (consent rate: 72 %; attrition: 5 %) randomised to the intervention (n = 166) or usual care (n = 165). The intervention comprised four group and one individual consultation all delivered by specialist uro-oncology nurses. Primary outcomes were anxious and depressive symptoms as assessed by the Hospital Anxiety and Depression Scale. Unmet needs were assessed with the Supportive Care Needs Survey-SF34 Revised, treatment-related concerns with the Cancer Treatment Scale and quality of life with the Expanded Prostate Cancer Index −26. Assessments occurred before, at the end of and 6 months post-radiotherapy. Primary outcome analysis was by intention-to-treat and performed by fitting a linear mixed model to each outcome separately using all observed data.

Results

Mixed models analysis indicated that group consultations had a significant beneficial effect on one of two primary endpoints, depressive symptoms (p = 0.009), and one of twelve secondary endpoints, procedural concerns related to cancer treatment (p = 0.049). Group consultations did not have a significant beneficial effect on generalised anxiety, unmet needs and prostate cancer-specific quality of life.

Conclusions

Compared with individual consultations offered as part of usual care, the intervention provides a means of delivering patient education and is associated with modest reductions in depressive symptoms and procedural concerns. Future work should seek to confirm the clinical feasibility and cost-effectiveness of group interventions.

Trial registration

Australian and New Zealand Clinical Trials Registry ANZCTRN012606000​184572. 1 March 2006.
Literature
1.
Smith DP, King MT, Egger S, Berry MP, Stricker PD, Cozzi P, et al. Quality of life 3 years after diagnosis of localised prostate cancer: population based cohort study. BMJ. 2009;339:b4817.CrossRefPubMedPubMedCentral
2.
Steginga SK, Occhipinti S, Dunn J, Gardiner RA, Heathcote P, Yaxley J. The supportive care needs of men with prostate cancer (2000). Psychooncology. 2001;10(1):66–75.CrossRefPubMed
3.
Little D, Kuban D, Levy L, Zagars G, Pollack A. Quality of life questionnaire results 2 and 3 years after radiotherapy for prostate cancer. Urology. 2003;62:707–13.CrossRefPubMed
4.
Carlson LE, Angen M, Cullum J, Goodey E, Koopmans J, Lamont L, et al. High levels of untreated distress and fatigue in cancer patients. Br J Cancer. 2004;90(12):2297–304.PubMedPubMedCentral
5.
Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S. The prevalence of psychological distress by cancer site. Psychooncology. 2001;10(1):19–28.CrossRefPubMed
6.
Korfage IJ, Essink-Bot ML, Janssens AC, Schröder FH, de Koning HJ. Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-up. Br J Cancer. 2006;94:1093–8.CrossRefPubMedPubMedCentral
7.
Sharifi N, Gulley JL, Dahut WL. Androgen deprivation therapy for prostate cancer. JAMA. 2005;294(2):238–44.CrossRefPubMed
8.
Baade PD, Youlden DR, Krnjacki LJ. International epidemiology of prostate cancer: geographical distribution and secular trends. Mol Nutr Food Res. 2009;53(2):171–84.CrossRefPubMed
9.
Chambers SK, Pinnock C, Lepore SJ, Hughes S, O’Connell DL. A systematic review of psychosocial interventions for men with prostate cancer and their partners. Patient Educ Couns. 2011;85(2):e75–88.CrossRefPubMed
10.
Penedo FJ, Dahn JR, Molton I, Gonzalez JS, Kinsinger D, Roos BA, et al. Cognitive-behavioral stress management improves stress-management skills and quality of life in men recovering from treatment of prostate carcinoma. Cancer. 2004;100(1):192–200.CrossRefPubMed
11.
Penedo FJ, Molton I, Dahn JR, Shen BJ, Kinsinger D, Traeger L, et al. A randomized clinical trial of group-based cognitive-behavioral stress management in localized prostate cancer: development of stress management skills improves quality of life and benefit finding. Ann Behavl Med. 2006;31(3):261–70.CrossRef
12.
Penedo FJ, Traeger L, Dahn J, Molton I, Gonzalez JS, Schneiderman N, et al. Cognitive behavioral stress management intervention improves quality of life in Spanish monolingual hispanic men treated for localized prostate cancer: results of a randomized controlled trial. Int J Behav Med. 2007;14(3):164–72.CrossRefPubMed
13.
Boonzaier A, Schubach K, Troup K, Pollard A, Aranda S, Schofield P. Development of a psychoeducational intervention for men with prostate cancer. J Psychosoc Oncol. 2009;27(1):136–53.CrossRefPubMed
14.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–70.CrossRefPubMed
15.
Roth AJ, Kornblith AB, Batel-Copel L, Peabody E, Scher HI, Holland JC. Rapid screening for psychologic distress in men with prostate carcinoma: a pilot study. Cancer. 1998;82(10):1904–8.CrossRefPubMed
16.
Schofield P, Gough K, Ugalde A, Carey M, Aranda S, Sanson-Fisher R. Cancer Treatment Survey (CaTS): development and validation of a new instrument to measure patients’ preparation for chemotherapy and radiotherapy. Psychooncology. 2012;21(3):307–15.CrossRefPubMed
17.
Schofield P, Gough K, Lotfi-Jam K, Aranda S. Validation of the Supportive Care Needs Survey—short form 34 with a simplified response format in men with prostate cancer. Psychooncology 2011:n/a-n/a.
18.
Wei JT, Dunn RL, Litwin MS, Sandler HM, Sanda MG. Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology. 2000;56(6):899–905.CrossRefPubMed
19.
Eldridge SM, Ashby D, Kerry S. Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method. Int J Epidemiol. 2006;35(5):1292–300.CrossRefPubMed
20.
Campbell MJ, Donner A, Klar N. Developments in cluster randomized trials and Statistics in Medicine. Stat Med. 2007;26(1):2–19.CrossRefPubMed
21.
Hox J. Multilevel analysis: Techniques and applications. Mahwah, NJ: Lawrence Erlbaum Associates; 2002.
22.
Yancy WS, Almirall D, Maciejewski ML, Kolotkin RL, McDuffie JR, Westman EC. Effects of two weight-loss diets on health-related quality of life. Qual Life Res. 2009;18:281–9.CrossRefPubMed
23.
Rasbash J, Charlton C, Browne WJ, Healy M, Cameron B. MLwiN Version 2.1. Bristol, UK: Centre for Multilevel Modelling, University of Bristol; 2009.
24.
Carmack Taylor CL, Demoor C, Smith MA, Dunn AL, Basen-Engquist K, Nielsen I, et al. Active for life after cancer: a randomized trial examining a lifestyle physical activity program for prostate cancer patients. Psychooncology. 2006;15(10):847–62.CrossRefPubMed
25.
Lepore SJ, Helgeson VS, Eton DT, Schulz R. Improving quality of life in men with prostate cancer: a randomized controlled trial of group education interventions. Health Psychol. 2003;22(5):443–52.CrossRefPubMedPubMedCentral
26.
27.
Sharpley CF, Bitsika V, Christie DH. Do prostate cancer patients suffer more from depressed mood or anhedonia? Psychooncology. 2013;22:1718–23.CrossRefPubMed
28.
Aranda S, Jefford M, Yates P, Gough K, Seymour J, Francis P, et al. Impact of a novel nurse-led prechemotherapy education intervention (ChemoEd) on patient distress, symptom burden, and treatment-related information and support needs: results from a randomised, controlled trial. Ann Oncol. 2012;23(1):222–31.CrossRefPubMed
29.
Zhang AY, Strauss GJ, Siminoff LA. Effects of combined pelvic floor muscle exercise and a support group on urinary incontinence and quality of life of postprostatectomy patients. Oncol Nurs Forum. 2007;34(1):47–53.CrossRefPubMed
30.
Linden W, Girgis A. Psychological treatment outcomes for cancer patients: what do meta-analyses tell us about distress reduction? Psychooncology. 2012;21(4):343–50.CrossRefPubMed
Metadata
Title
Nurse-led group consultation intervention reduces depressive symptoms in men with localised prostate cancer: a cluster randomised controlled trial
Authors
Penelope Schofield
Karla Gough
Kerryann Lotfi-Jam
Rebecca Bergin
Anna Ugalde
Paul Dudgeon
Wallace Crellin
Kathryn Schubach
Farshard Foroudi
Keen Hun Tai
Gillian Duchesne
Rob Sanson-Fisher
Sanchia Aranda
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2687-1

Other articles of this Issue 1/2016

BMC Cancer 1/2016 Go to the issue

Research article

Thoracic perfusion of recombinant human endostatin (Endostar) combined with chemotherapeutic agents versus chemotherapeutic agents alone for treating malignant pleural effusions: a systematic evaluation and meta-analysis

Research article

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia

Research article

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: pilot data exchange and analyses

Research article

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Research article

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma

Research article

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits