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Open Access 01-12-2015 | Study protocol

From prospective biobanking to precision medicine: BIO-RAIDs – an EU study protocol in cervical cancer

Authors: Charlotte Ngo, Sanne Samuels, Ksenia Bagrintseva, Andrea Slocker, Philippe Hupé, Gemma Kenter, Marina Popovic, Nina Samet, Patricia Tresca, Heiko von der Leyen, Eric Deutsch, Roman Rouzier, Lisa Belin, Maud Kamal, Suzy Scholl, RAIDs consortium http://www.raids-fp7.eu/

Published in: BMC Cancer | Issue 1/2015

Abstract

Background

Cervical cancer (CC) is -second to breast cancer- a dominant cause of gynecological cancer-related deaths worldwide. CC tumor biopsies and blood samples are of easy access and vital for the development of future precision medicine strategies.

Design

BIO-RAIDs is a prospective multicenter European study, presently recruiting patients in 6 EU countries. Tumor and liquid biopsies from patients with previously non-treated cervical cancer (stages IB2-IV) are collected at defined time points. Patients receive standard primary treatment according to the stage of their disease. 700 patients are planned to be enrolled. The main objectives are the discovery of -dominant molecular alterations, -signalling pathway activation, and -tumor micro-environment patterns that may predict response or resistance to treatment. An exhaustive molecular analysis is performed using 1° Next generation sequencing, 2° Reverse phase protein arrays and 3° Immuno-histochemistry.

Discussion

The clinical study BIO-RAIDs is activated in all planned countries, 170 patients have been recruited till now. This study will make an important contribution towards precision medicine treatments in cervical cancer. The results will support the development of clinical practice guidelines for cervical cancer patients to improve their prognosis and their quality of life.

Trial registration

Clinicaltrials.gov: NCT02428842, registered 10 February 2015.

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Title: From prospective biobanking to precision medicine: BIO-RAIDs – an EU study protocol in cervical cancer
Authors: Charlotte Ngo
Sanne Samuels
Ksenia Bagrintseva
Andrea Slocker
Philippe Hupé
Gemma Kenter
Marina Popovic
Nina Samet
Patricia Tresca
Heiko von der Leyen
Eric Deutsch
Roman Rouzier
Lisa Belin
Maud Kamal
Suzy Scholl
RAIDs consortium http://www.raids-fp7.eu/
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-015-1801-0

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Abstract

Background

Design

Discussion

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