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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Research article

Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection

Authors: Yan-Ming Zhou, Xiao-Feng Zhang, Bin Li, Cheng-Jun Sui, Jia-Mei Yang

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

Postoperative recurrence remains the major cause of death after curative resection for hepatocellular carcinoma (HCC). This study was conducted to evaluate the impact of postoperative complications on HCC recurrence after curative resection.

Methods

The postoperative outcomes of 274 HCC patients who underwent curative resection were analysed retrospectively.

Results

Of the 247 HCC patients, 103 (37.6 %) patients developed postoperative complications. The occurrence of postoperative complications was found to be associated with a significantly higher tumor recurrence (76.2 % vs. 56.6 %, P = 0.002) and a lower 5-year overall survival rate (27.7 % vs. 42.1 %; P = 0.037) as compared with those without complications. Regarding the recurrence pattern, early recurrence (≤2 years) was more frequently seen in patients with complications than that in patients without complications (54.5 % vs.38.6 %; P = 0.011). Multivariate analysis indicated that postoperative complications occurrence was an independent risk factor for early recurrence (odds ratio [OR] 2.223; 95 % confidence intervals [95 % CI] 1.161–4.258, P = 0.016) and poor overall survival (OR 1.413; 95 % CI, 1.012–1.971, P = 0.042).

Conclusions

The results of the present study indicate that the occurrence of postoperative complications is a predictive factor for HCC recurrence after curative hepatectomy, especially for early recurrence.
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Metadata
Title
Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection
Authors
Yan-Ming Zhou
Xiao-Feng Zhang
Bin Li
Cheng-Jun Sui
Jia-Mei Yang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1720-0

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