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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Research article

Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology

Authors: Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo, Tai-An Chen

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia.

Methods

The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically.

Results

A total of 72 patients, including 66 males and 6 females, with mean age of 54.6 ± 11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95 %: 3.81–72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95 %, 78.43 %, 60.71 %, 90.91 %, and 79.17 %, respectively, which were significantly better than other two established NBI criteria (p < 0.001).

Conclusions

Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia.
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Metadata
Title
Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology
Authors
Shih-Wei Yang
Yun-Shien Lee
Liang-Che Chang
Cheng-Cheng Hwang
Cheng-Ming Luo
Tai-An Chen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1422-7

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