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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Case report

Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options

Authors: Valeriya Semenisty, Inna Naroditsky, Zohar Keidar, Gil Bar-Sela

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

Epithelioid hemangioendothelioma is a rare vascular tumor of borderline or low-grade malignancy. The lungs and liver are the two common primary organs affected. Metastatic disease was reported in more than 100 cases in the literature. However, no firm conclusions can be determined for recommended treatment options.

Case presentation

The current case presents a patient with metastatic pulmonary epithelioid hemangioendothelioma to the cervical and mediastinal lymph nodes, lungs and liver that has been treated with pazopanib for more than two years with PET avid complete metabolic response in the mediastinum and lungs, and long-lasting stable disease. Target therapies that block VEGFR have a logical base in this rare malignancy.

Conclusions

The current case is the first to report objective, long-lasting response to pazopanib.
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Metadata
Title
Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options
Authors
Valeriya Semenisty
Inna Naroditsky
Zohar Keidar
Gil Bar-Sela
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1395-6

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