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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Research article

Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer

Authors: Liang Hu, Hai-Yang Chen, Jian Cai, Yu Zhang, Chen-Ye Qi, Hui Gong, Yan-Xia Zhai, Hao Fu, Guang-Zhen Yang, Chun-Fang Gao

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

Aberrant expression of serine threonine tyrosine kinase 1 (STYK1) has been reported in several human malignancies including colorectal cancer (CRC). However, the prognostic significance of STYK1 expression in CRC remains unknown.

Methods

STYK1 protein expression in paraffin-embedded CRC specimens was determined immunohistochemically. The correlation of STYK1 expression with clinicopathologic features was assessed in a cohort containing 353 patients with primary CRC. Kaplan-Meier and Cox proportional regression analyses were used to evaluate the association between STYK1 expression and patients’ survival.

Results

STYK1 expression was frequently up-regulated in CRC clinical samples at the protein levels and was significantly associated with tumor differentiation grade (p = 0.030), lymph node metastasis (p = 0.004), TNM stage (p = 0.007) and patient death (p < 0.001). Kaplan-Meier analysis indicated that patients with high intratumoral STYK1 expression had a significantly shorter disease-specific survival (DSS) than those with low expression (p < 0.001). Importantly, high levels of STYK1 protein predicted poor DSS for both stage II (p < 0.001) and stage III (p = 0.004) patients. Furthermore, multivariate analyses revealed that STYK1 protein expression was an independent prognostic indicator for both stage II (hazard ratio [HR], 2.472; p = 0.001) and stage III (HR, 2.001; p = 0.004) patients.

Conclusions

Our results suggest that increased STYK1 protein expression correlates with disease progression and metastasis and may serve as a predictor of poor survival in CRC.
Appendix
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Literature
1.
2.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.CrossRefPubMed
3.
Guo P, Huang ZL, Yu P, Li K. Trends in cancer mortality in China: an update. Ann Oncol. 2012;23(10):2755–62.CrossRefPubMed
4.
5.
Nagtegaal ID, Quirke P, Schmoll HJ. Has the new TNM classification for colorectal cancer improved care? Nat Rev Clin Oncol. 2012;9(2):119–23.CrossRef
6.
7.
8.
Liu L, Yu XZ, Li TS, Song LX, Chen PL, Suo TL, et al. A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Res. 2004;64(10):3491–9.CrossRefPubMed
9.
Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, et al. Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. Mol Biol Rep. 2003;30(2):91–6.CrossRefPubMed
10.
Chung S, Tamura K, Furihata M, Uemura M, Daigo Y, Nasu Y, et al. Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer. Cancer Sci. 2009;100(11):2109–14.CrossRefPubMed
11.
Kondoh T, Kobayashi D, Tsuji N, Kuribayashi K, Watanabe N. Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia. Exp Hematol. 2009;37(7):824–30.CrossRefPubMed
12.
Chen Y, Li YH, Chen XP, Gong LM, Zhang SP, Chang ZJ, et al. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer Res. 2005;65(23):10838–46.CrossRefPubMed
13.
Moriai R, Kobayashi D, Amachika T, Tsuji N, Watanabe N. Diagnostic relevance of overexpressed NOK mRNA in breast cancer. Anticancer Res. 2006;26(6C):4969–73.PubMed
14.
Amachika T, Kobayashi D, Moriai R, Tsuji N, Watanabe N. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. Lung Cancer. 2007;56(3):337–40.CrossRefPubMed
15.
16.
Orang AV, Safaralizadeh R, Hosseinpour Feizi MA, Somi MH. Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer. Asian Pac J Cancer Prev. 2014;15(16):6685–9.CrossRefPubMed
17.
Chen P, Li WM, Lu Q, Wang J, Yan XL, Zhang ZP, et al. Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer. BMC Cancer. 2014;14:402.CrossRefPubMedPubMedCentral
18.
Nirasawa S, Kobayashi D, Kondoh T, Kuribayashi K, Tanaka M, Yanagihara N, et al. Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. Int J Oncol. 2014;45(5):1867–74.PubMed
19.
Wang RY, Chen L, Chen HY, Hu L, Li L, Sun HY, et al. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. Gastroenterol. 2013;145(6):1436–48 e1431-1412.
20.
Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, et al. The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma. Clin Cancer Res. 2013;19(8):2014–24.CrossRefPubMed
21.
Li MH, Dong LW, Li SX, Tang GS, Pan YF, Zhang J, et al. Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. Cancer Lett. 2013;337(2):248–53.CrossRefPubMed
22.
Li W, Yu CP, Xia JT, Zhang L, Weng GX, Zheng HQ, et al. Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res. 2009;15(4):1393–9.CrossRefPubMed
23.
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298(5600):1912–34.CrossRefPubMed
24.
25.
26.
Li J, Wu F, Sheng F, Li YJ, Jin D, Ding X, et al. NOK/STYK1 interacts with GSK-3beta and mediates Ser9 phosphorylation through activated Akt. FEBS Lett. 2012;586(21):3787–92.CrossRefPubMed
27.
Webber C, Gospodarowicz M, Sobin LH, Wittekind C, Greene FL, Mason MD, et al. Improving the TNM classification: findings from a 10-year continuous literature review. Int J Cancer. 2014;135(2):371–8.CrossRefPubMed
Metadata
Title
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer
Authors
Liang Hu
Hai-Yang Chen
Jian Cai
Yu Zhang
Chen-Ye Qi
Hui Gong
Yan-Xia Zhai
Hao Fu
Guang-Zhen Yang
Chun-Fang Gao
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1285-y

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