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BMC Pregnancy and Childbirth

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01-12-2020 | Sectio Ceasarea | Research article

Intraoperative cell salvage for obstetrics: a prospective randomized controlled clinical trial

Authors: Ye Liu, Xiaoguang Li, Xiangming Che, Guosheng Zhao, Mingjun Xu

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

Abstract

Background

The latest basic studies and clinical evidence have confirmed the safety and efficacy of intraoperative autologous blood cell transfusion in cardiac surgery and orthopaedics. However, in caesarean section, there are still concerns about the contamination of amniotic fluid and foetal components, and consequently the application of intraoperative autologous blood cell transfusion is not universal. Therefore, this study aimed to evaluate the clinical value of intraoperative autologous blood cell transfusion in obstetric surgery.

Methods

A prospective, randomized, controlled, feasibility study was performed in women undergoing caesarean section. One hundred sixteen participants were randomly assigned at a 1:1 ratio into either the intraoperative cell salvage group or the control group. Allogeneic blood cells were transfused into patients with haemoglobin concentrations < 80 g/dL in both the intraoperative cell salvage group and the control group.

Results

No significant differences were found between the two groups in age, weight, maternal parity, history of previous caesarean section, gestational weeks of delivery, etc. However, compared with the control group, patients in the intraoperative cell salvage group had a significantly lower amount of allogeneic blood cell transfusion, lower incidence of postoperative incision infection, delayed wound healing, perioperative allergy, adverse cardiovascular events, hypoproteinaemia and shorter hospital stay.

Conclusion

The results of this study suggest that the use of autologous blood cell transfusion is safe and effective for patients with obstetric haemorrhage. Trial registration: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional and/or National Research Committee of Beijing Obstetrics and Gynecology Hospital, Capital Medical University (2016-XJS-003-01) as well as the 1964 Helsinki Declaration and its later amendments or other comparable ethical standards. The clinical trials were registered (ChiCTR-ICC-15,007,096) on September 28, 2015.

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Title: Intraoperative cell salvage for obstetrics: a prospective randomized controlled clinical trial
Authors: Ye Liu
Xiaoguang Li
Xiangming Che
Guosheng Zhao
Mingjun Xu
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Sectio Ceasarea
Amniotic Fluid Embolism
Obstetric Surgery
Sectio Caesarea
Published in: BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-020-03138-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraoperative cell salvage for obstetrics: a prospective randomized controlled clinical trial

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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