Skip to main content
Top
Published in: BMC Pregnancy and Childbirth 1/2020

Open Access 01-12-2020 | Care | Research article

Pre-existing mental health disorders affect pregnancy and neonatal outcomes: a retrospective cohort study

Authors: Kotryna Sūdžiūtė, Greta Murauskienė, Kristina Jarienė, Algirdas Jaras, Meilė Minkauskienė, Virginija Adomaitienė, Irena Nedzelskienė

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

Login to get access

Abstract

Background

This was a hospital registry-based retrospective age-matched cohort study that aimed to compare pregnancy and neonatal outcomes of women with pre-existing mental disorders with those of mentally healthy women.

Methods

A matched cohort retrospective study was carried out in the Department of Obstetrics and Gynecology, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, a tertiary health care institution. Medical records of pregnant women who gave birth from 2006 to 2015 were used. The study group was comprised of 131 pregnant women with mental disorders matched to 228 mentally healthy controls. The primary outcomes assessed were antenatal care characteristics; secondary outcomes were neonatal complications.

Results

Pregnant women with pre-existing mental health disorders were significantly more likely to have low education, be unmarried and unemployed, have a disability that led to lower working capacity, smoke more frequently, have chronic concomitant diseases, attend fewer antenatal visits, gain less weight, be hospitalized during pregnancy, spend more time in hospital during the postpartum period, and were less likely to breastfeed their newborns. The newborns of women with pre-existing mental disorders were small for gestational age (SGA) more often than those of healthy controls (12.9% vs. 7.6%, p < 0.05). No difference was found comparing the methods of delivery.

Conclusions

Women with pre-existing mental health disorders had a worse course of pregnancy. Mental illness increased the risk to deliver a SGA newborn (RR 2.055, 95% CI 1.081–3.908).
Literature
2.
go back to reference Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159(7):1080-92.PubMed Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159(7):1080-92.PubMed
3.
go back to reference Hoirisch-Clapauch S, Brenner B, Nardi AE. Adverse obstetric and neonatal outcomes in women with mental disorders. Thromb Res. 2015;135(1):60 – 3.CrossRef Hoirisch-Clapauch S, Brenner B, Nardi AE. Adverse obstetric and neonatal outcomes in women with mental disorders. Thromb Res. 2015;135(1):60 – 3.CrossRef
4.
go back to reference Judd F, Komiti A, Sheehan P, Newman L, Castle D, Everall I. Adverse obstetric and neonatal outcomes in women with severe mental illness: To what extent can they be prevented? Schizophr Res. 2014;157(1–3):305–9.PubMedCrossRef Judd F, Komiti A, Sheehan P, Newman L, Castle D, Everall I. Adverse obstetric and neonatal outcomes in women with severe mental illness: To what extent can they be prevented? Schizophr Res. 2014;157(1–3):305–9.PubMedCrossRef
5.
go back to reference Maghsoudlou S, Cnattingius S, Montgomery S, Aarabi M, Semnani S, Anna-Karin Wikström. et al. Opium use during pregnancy and infant size at birth: a cohort study. BMC Pregnancy and Childbirth. 2018;18(1)358. Maghsoudlou S, Cnattingius S, Montgomery S, Aarabi M, Semnani S, Anna-Karin Wikström. et al. Opium use during pregnancy and infant size at birth: a cohort study. BMC Pregnancy and Childbirth. 2018;18(1)358.
6.
go back to reference Kalaitzopoulos D, Chatzistergiou K, Amylidi A, Kokkinidis D, Goulis D. Effect of Methamphetamine Hydrochloride on Pregnancy Outcome. Journal of Addiction Medicine. 2018;12(3):220–6.PubMedCrossRef Kalaitzopoulos D, Chatzistergiou K, Amylidi A, Kokkinidis D, Goulis D. Effect of Methamphetamine Hydrochloride on Pregnancy Outcome. Journal of Addiction Medicine. 2018;12(3):220–6.PubMedCrossRef
7.
go back to reference Nguyen TN, Faulkner D, Frayne JS, Allen S, Hauck YL, Rock D, Rampono J. 2012.Obstetric and neonatal outcomes of pregnant women with severe mental illness ata specialist antenatal clinic.2013; 199(3): 26–9. Nguyen TN, Faulkner D, Frayne JS, Allen S, Hauck YL, Rock D, Rampono J. 2012.Obstetric and neonatal outcomes of pregnant women with severe mental illness ata specialist antenatal clinic.2013; 199(3): 26–9.
8.
go back to reference Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. BMJ Open. 2013;3(7):e003062.PubMedPubMedCentralCrossRef Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. BMJ Open. 2013;3(7):e003062.PubMedPubMedCentralCrossRef
9.
go back to reference La Merrill M, Stein CR, Landrigan P, Engel SM, Savitz DA. Prepregnancy body mass index, smoking during pregnancy, and infant birth weight. Ann Epidemiol. 2011;21(6): 413 – 20.PubMedPubMedCentralCrossRef La Merrill M, Stein CR, Landrigan P, Engel SM, Savitz DA. Prepregnancy body mass index, smoking during pregnancy, and infant birth weight. Ann Epidemiol. 2011;21(6): 413 – 20.PubMedPubMedCentralCrossRef
10.
go back to reference Chang H, Keyes K, Lee K, Choi I, Kim S, Kim K. et al. Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea. Early Human Dev. 2014;90(1):15–20.CrossRef Chang H, Keyes K, Lee K, Choi I, Kim S, Kim K. et al. Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea. Early Human Dev. 2014;90(1):15–20.CrossRef
11.
go back to reference Ehrenkranz R. Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data. Yearbook of Neonatal Perinatal Medicine. 2007;2007:34–8.CrossRef Ehrenkranz R. Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data. Yearbook of Neonatal Perinatal Medicine. 2007;2007:34–8.CrossRef
12.
go back to reference Shah P. Paternal factors and low birthweight, preterm, and small for gestational age births: a systematic review. Am J Obstet Gynecol. 2010;202(2):103–23.PubMedCrossRef Shah P. Paternal factors and low birthweight, preterm, and small for gestational age births: a systematic review. Am J Obstet Gynecol. 2010;202(2):103–23.PubMedCrossRef
14.
go back to reference Ferraro AA, Rohde LA, Polanczyk GV, Argeu A, Miguel EC, Grisi SJFE, Fleitlich-Bilyk B. The specific and combined role of domestic violence and mental health disorders during pregnancy on new-born health. BMC Pregnancy Childbirth. 2017;17:257.PubMedPubMedCentralCrossRef Ferraro AA, Rohde LA, Polanczyk GV, Argeu A, Miguel EC, Grisi SJFE, Fleitlich-Bilyk B. The specific and combined role of domestic violence and mental health disorders during pregnancy on new-born health. BMC Pregnancy Childbirth. 2017;17:257.PubMedPubMedCentralCrossRef
15.
go back to reference Howard L, Goss C, Leese M, Thornicroft G. Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth. Br J Psychiatry. 2003;182(01):63–7.PubMedCrossRef Howard L, Goss C, Leese M, Thornicroft G. Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth. Br J Psychiatry. 2003;182(01):63–7.PubMedCrossRef
16.
go back to reference Abraham M, Alramadhan S, Iniguez C. et al. A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis. PLoS One. 2017;12(2):e0170946.PubMedPubMedCentralCrossRef Abraham M, Alramadhan S, Iniguez C. et al. A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis. PLoS One. 2017;12(2):e0170946.PubMedPubMedCentralCrossRef
18.
go back to reference Inoue S, Naruse H, Yorifuji T. et al. Impact of maternal and paternal smoking on birth outcomes. J Public Health (Oxf). 2017;39(3):1–10.CrossRef Inoue S, Naruse H, Yorifuji T. et al. Impact of maternal and paternal smoking on birth outcomes. J Public Health (Oxf). 2017;39(3):1–10.CrossRef
19.
go back to reference Staneva A, Bogossian F, Pritchard M, Wittkowski A. The effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: A systematic review. Women Birth. 2015;28(3):179–93.PubMedCrossRef Staneva A, Bogossian F, Pritchard M, Wittkowski A. The effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: A systematic review. Women Birth. 2015;28(3):179–93.PubMedCrossRef
20.
go back to reference Tomita A, Labys C, Burns J. Depressive Symptoms Prior to Pregnancy and Infant Low Birth Weight in South Africa. Matern Child Health J. 2015;19(10):2179–86.PubMedPubMedCentralCrossRef Tomita A, Labys C, Burns J. Depressive Symptoms Prior to Pregnancy and Infant Low Birth Weight in South Africa. Matern Child Health J. 2015;19(10):2179–86.PubMedPubMedCentralCrossRef
21.
go back to reference Zhao L, McCauley K, Sheeran L. The interaction of pregnancy, substance use and mental illness on birthing outcomes in Australia. Midwifery. 2017;54:81–8.PubMedCrossRef Zhao L, McCauley K, Sheeran L. The interaction of pregnancy, substance use and mental illness on birthing outcomes in Australia. Midwifery. 2017;54:81–8.PubMedCrossRef
22.
go back to reference Boyle B, Garne E, Loane M, Addor M, Arriola L, Cavero-Carbonell C. et al. The changing epidemiology of Ebstein’s anomaly and its relationship with maternal mental health conditions: a European registry-based study. Cardiol Young. 2016;27(4):677–85.PubMedCrossRef Boyle B, Garne E, Loane M, Addor M, Arriola L, Cavero-Carbonell C. et al. The changing epidemiology of Ebstein’s anomaly and its relationship with maternal mental health conditions: a European registry-based study. Cardiol Young. 2016;27(4):677–85.PubMedCrossRef
23.
go back to reference Sutter-Dallay A, Bales M, Pambrun E, Glangeaud-Freudenthal N, Wisner K, Verdoux H. Impact of Prenatal Exposure to Psychotropic Drugs on Neonatal Outcome in Infants of Mothers With Serious Psychiatric Illnesses. The Journal of Clinical Psychiatry. 2015;76(07):967–73.PubMedCrossRef Sutter-Dallay A, Bales M, Pambrun E, Glangeaud-Freudenthal N, Wisner K, Verdoux H. Impact of Prenatal Exposure to Psychotropic Drugs on Neonatal Outcome in Infants of Mothers With Serious Psychiatric Illnesses. The Journal of Clinical Psychiatry. 2015;76(07):967–73.PubMedCrossRef
24.
go back to reference Vigod S, Kurdyak P, Dennis C, Gruneir A, Newman A, Seeman M. et al. Maternal and Newborn Outcomes Among Women With Schizophrenia. Obstetric Anesthesia Digest. 2015;35(2):100.CrossRef Vigod S, Kurdyak P, Dennis C, Gruneir A, Newman A, Seeman M. et al. Maternal and Newborn Outcomes Among Women With Schizophrenia. Obstetric Anesthesia Digest. 2015;35(2):100.CrossRef
25.
go back to reference Smith M, Shao L, Howell H, Lin H, Yonkers K. Perinatal Depression and Birth Outcomes in a Healthy Start Project. Matern Child Health J. 2010;15(3):401–9.CrossRef Smith M, Shao L, Howell H, Lin H, Yonkers K. Perinatal Depression and Birth Outcomes in a Healthy Start Project. Matern Child Health J. 2010;15(3):401–9.CrossRef
28.
go back to reference Dolman C, Jones I, Howard LH. Pre-conception to parenting: a systematic review and meta-synthesis of the qualitative literature on motherhood for women with severe mental illness. ArchWomens Health. 2013;16(3):173 – 96. Dolman C, Jones I, Howard LH. Pre-conception to parenting: a systematic review and meta-synthesis of the qualitative literature on motherhood for women with severe mental illness. ArchWomens Health. 2013;16(3):173 – 96.
Metadata
Title
Pre-existing mental health disorders affect pregnancy and neonatal outcomes: a retrospective cohort study
Authors
Kotryna Sūdžiūtė
Greta Murauskienė
Kristina Jarienė
Algirdas Jaras
Meilė Minkauskienė
Virginija Adomaitienė
Irena Nedzelskienė
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-020-03094-5

Other articles of this Issue 1/2020

BMC Pregnancy and Childbirth 1/2020 Go to the issue