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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2019

Open Access 01-12-2019 | Fertility | Case report

Fertility preservation with successful pregnancy outcome in a patient with transplanted heart and non-Hodgkin’s lymphoma – a case report

Authors: Ana Sofia Pais, Nuno Guerra, Daniela Couto, Ana Paula Sousa, Teresa Almeida-Santos

Published in: BMC Pregnancy and Childbirth | Issue 1/2019

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Abstract

Background: Fertility preservation must be discussed with reproductive age women before cancer treatment. Heart transplantation raises complex issues in pregnancy. Pregnancy in a heart transplant woman after pelvic irradiation involves close multidisciplinary follow-up to avoid complications in the mother and the foetus. We report the first live birth in a heart transplant woman after pelvic irradiation, chemotherapy and fertility preservation.
Case presentation: A 36-year-old heart transplant woman with pelvic non-Hodgkin lymphoma spared her fertility, with cryopreservation of oocytes and embryos, before chemotherapy and pelvic irradiation. After multidisciplinary discussion and pre-conception evaluation, pregnancy was achieved. A close follow-up by a multidisciplinary team allowed a normal pregnancy without maternal or foetal complications and the delivery of a healthy infant.

Conclusions

Achieving pregnancy in heart transplant women with iatrogenic ovarian failure after oncologic treatment including pelvic irradiation is possible and can be successful. Careful and close surveillance by a multidisciplinary team is mandatory due to increased risk of maternal and foetal complications.
Literature
1.
Donnez J, Dolmans M-M. Fertility preservation in women. N Engl J Med. 2017;377(17):1657–65.CrossRef
2.
Teh WT, Stern C, Chander S, Hickey M. The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Biomed Res Int. 2014;2014.
3.
Cowan SW, Davison JM, Doria C, Moritz MJ, Armenti VT. Pregnancy after cardiac transplantation pregnancy heart transplantation. Cardiol Clin. 2012;30(3):441–52.CrossRef
4.
Abdalla M, Mancini DM. Management of Pregnancy in the post-cardiac transplant patient. Semin Perinatol. 2014;38(5):318–25.CrossRef
5.
6.
Nicolaides KH, Wright D, Syngelaki A, Wright A, Akolekar R. Fetal Medicine Foundation fetal and neonatal population weight charts. Ultrasound Obstet Gynecol. 2018;52(1):44–51.CrossRef
7.
Wo J, Viswanathan A. The impact of radiotherapy on fertility, pregnancy, and neonatal outcomes of female Cancer patients. Int J Radiat Oncol Biol Phys. 2009;73(5):1304–12.CrossRef
8.
Coscia L, Constantinescu S, Moritz M, Frank A, Ramirez C, Doria C, et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl. 2011:65–85.
9.
Ferreri A, Verona C, Bolognesi A, Taccagni G, Ponzoni M, Ferrari S. Successful pregnancy after chemo-immuno-radiation therapy for aggressive lymphoma of the uterus. Br J Haematol. 2008;142(1):141–3.CrossRef
10.
Chen C, Kaushal N, Scher DM, Doyle SM, Blanco JS, Dodwell ER. Clubfoot etiology. J Pediatr Orthop. 2018;38(8):e462–9.CrossRef
11.
Nishimura RA, Otto CM, Bonow RO, Iii JPE, Fleisher LA, Jneid H, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the Management of Patients with Valvular Heart Disease. A report of the American College of Cardiology/American Heart Association Task force on clinical practice guidelines. J Am Coll Cardiol. 2017;70(2):252–89.CrossRef
12.
Constantinescu S, Pai A, Coscia L, Davison JM, Moritz M, Armenti V. Breast-feeding after transplantation. Best Pract Res Clin Obstet Gynaecol. 2014;28:1163–73.CrossRef
13.
Mahajan N. Fertility preservation in female cancer patients: an overview. J Hum Reprod Sci. 2015;8(1):3.CrossRef
14.
Task A, Members F, Chairperson VR, Blomstro C, Renata C, France BI, et al. 2018 ESC guidelines for themanagement of cardiovascular diseases during pregnancy. Vol. 72, rev. Esp Cardiol (English ed.). 2019:161.
Metadata
Title
Fertility preservation with successful pregnancy outcome in a patient with transplanted heart and non-Hodgkin’s lymphoma – a case report
Authors
Ana Sofia Pais
Nuno Guerra
Daniela Couto
Ana Paula Sousa
Teresa Almeida-Santos
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2019
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-019-2587-x

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