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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2018

Open Access 01-12-2018 | Research article

Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis

Authors: Li Jiao-ling, Geng Xiu-ping, Chen Kun-shan, He Qiu-ming, Li Xiao-fen, Yang Bo-yang, Fang Qian

Published in: BMC Pregnancy and Childbirth | Issue 1/2018

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Abstract

Background

Although huge fetal hepatic hemangiomas are rare, they can cause fatal complications. The purpose of this study is to describe the imaging features and prognosis of these tumors.

Methods

Imaging data were collected for 6 patients with huge fetal hepatic hemangiomas treated at our hospital. Imaging modalities included prenatal magnetic resonance imaging and ultrasound and postnatal color Doppler ultrasound and contrast-enhanced computed tomography (CT).

Results

Among the 93,562 fetuses of 92,126 pregnant women examined at our hospital, 6 had huge hepatic hemangiomas (incidence rate, 0.64/10,000), as confirmed via postnatal color Doppler imaging and contrast-enhanced CT. Five fetuses had solitary lesions, whereas 1 (fetus 2) had multiple lesions. Four fetuses had lesions in the right liver lobe and 1 had a lesion in the left liver lobe, and 1 (fetus 2) had lesions in both lobes. All lesions showed centripetal enhancement on postnatal contrast-enhanced CT, which was more intense peripherally. Following postnatal treatment with oral propranolol, with or without dexamethasone or interventional therapy with the medical sclerosant pingyangmycin, all lesions decreased in size, with calcification plaques appearing 6 months after treatment.

Conclusions

Huge hepatic hemangiomas have typical ultrasonographic features and can be diagnosed prenatally. Treatment with propranolol, with or without dexamethasone, may result in a favorable prognosis.
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Literature
1.
Kamil D, Tepelmann J, Berg C, Heep A, Axt-Fliedner R, Gembruch U, et al. Spectrum and outcome of prenatally diagnosed fetal tumors. Ultrasound Obstet Gynecol. 2008;31(3):296–302.CrossRefPubMed
2.
3.
Mulliken JB, Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol. 2004;50(6):875–82.CrossRefPubMed
4.
Cohen MM Jr. Hemangiomas: their uses and abuses. Am J Med Genet A. 2007;143(3):235–40.CrossRef
5.
Dreyfus M, Baldauf JJ, Dadoun K, Becmeur F, Berrut F, Ritter J. Prenatal diagnosis of hepatic hemangioma. Fetal Diagn Ther. 1996;11(1):57–60.CrossRefPubMed
6.
Helmberger TK, Ros PR, Mergo PJ, Tomczak R, Reiser MF. Pediatric liver neoplasms: a radiologic-pathologic correlation. Eur Radiol. 1999;9(7):1339–47.CrossRefPubMed
7.
Pott Bartsch EM, Paek BW, Yoshizawa J, Goldstein RB, Ferrell LD, Coakley FV, et al. Giant fetal hepatic hemangioma: case report and literature review. Fetal Diagn Ther. 2003;18(1):59–64.CrossRefPubMed
8.
Chuileannain FN, Rowlands S, Sampson A. Ultrasonographic appearances of fetal hepatic hemangioma. J Ultrasound Med. 1999;18(5):379–81.CrossRefPubMed
9.
Aslan H, Dural O, Yildirim G, Acar DK. Prenatal diagnosis of a liver cavernous hemangioma. Fetal Pediatr Pathol. 2013;32(5):341–5.CrossRefPubMed
10.
Sur A, Manraj H, Lavoie PM, Lim K, Courtemanche D, Brooks P, et al. Multiple successful angioembolizations for refractory cardiac failure in a preterm with rapidly involuting congenital hemangioma. AJP Rep. 2016;6(1):99–103.CrossRef
11.
Morimura Y, Fujimori K, Ishida T, Ito A, Nomura Y, Sato A. Fetal hepatic hemangioma representing non-reassuring pattern in fetal heart rate monitoring. J Obstet Gynaecol Res. 2003;29(5):347–50.CrossRefPubMed
12.
Franchi-Abella S, Gorincour G, Avni F, Guibaud L, Chevret L, Pariente D. SFIPP-GRRIF (Société Francophone d’Imagerie Pédiatrique et Périnatale-Groupe de Recherche Radiopédiatrique en Imagerie Foetale). Hepatic haemangioma-prenatal imaging findings, complications and perinatal outcome in a case series. Pediatr Radiol. 2012;42(3):298–307.CrossRefPubMed
13.
Hou J, Wang M, Tang H, Wang Y, Huang H. Pingyangmycin sclerotherapy for infantile hemangiomas in oral and maxillofacial regions: an evaluation of 66 consecutive patients. Int J Oral Maxillofac Surg. 2011;40(11):1246–51.CrossRefPubMed
14.
Wang H. editor-in-chief. Topographic anatomy. Shelton: People’s Medical Publishing House; 2005. p. 187.
15.
16.
17.
Lutgendorf MA, Magann EF, Yousef M, Hill JB, Foster DT. Hepatic epithelial hemangioendothelioma in pregnancy. Gynecol Obstet Investig. 2009;67(4):238–40.CrossRef
18.
Gembruch U, Baschat AA, Gloeckner-Hoffmann K, Gortner L, Germer U. Prenatal diagnosis and management of fetuses with liver hemangiomata. Ultrasound Obstet Gynecol. 2002;19(5):454–60.CrossRefPubMed
19.
Dong SZ, Zhu M, Zhong YM, Yin MZ. Use of foetal MRI in diagnosing hepatic hemangioendotheliomas: a report of four cases. Eur J Radiol. 2010;75(3):301–5.CrossRefPubMed
20.
Meirowitz NB, Guzman ER, Underberg-Davis SJ, Pellegrino JE, Vintzileos AM. Hepatic hemangioendothelioma: prenatal sonographic findings and evolution of the lesion. J Clin Ultrasound. 2000;28(5):258–63.CrossRefPubMed
21.
Chou SY, Chiang HK, Chow PK, Wu CF, Liang SJ, Hsu CS. Fetal hepatic hemangioma diagnosed prenatally with ultrasonography. Acta Obstet Gynecol Scand. 2005;84(3):301–2.CrossRefPubMed
22.
Schmitz R, Heinig J, Klockenbusch W, Kiesel L, Steinhard J. Antenatal diagnosis of a giant fetal hepatic hemangioma and treatment with maternal corticosteroid. Ultraschall Med. 2009;30(3):223–6.CrossRefPubMed
23.
Morris J, Abbott J, Burrows P, Levine D. Antenatal diagnosis of fetal hepatic hemangioma treated with maternal corticosteroids. Obstet Gynecol. 1999;94(5):813–5.CrossRefPubMed
Metadata
Title
Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis
Authors
Li Jiao-ling
Geng Xiu-ping
Chen Kun-shan
He Qiu-ming
Li Xiao-fen
Yang Bo-yang
Fang Qian
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2018
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-017-1635-7

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