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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2017

Open Access 01-12-2017 | Case report

Congenital tuberculosis in an extremely preterm infant conceived after in vitro fertilization: case report

Authors: Veronica Samedi, Stephen K. Field, Essa Al Awad, Gregory Ratcliffe, Kamran Yusuf

Published in: BMC Pregnancy and Childbirth | Issue 1/2017

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Abstract

Background

Congenital tuberculosis is a rare manifestation of tuberculosis. The diagnosis is often delayed, especially in preterm neonates because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy.

Case Presentation

We report a case of congenital tuberculosis in an infant born at 24 weeks of gestation to a mother who presented with uncontrolled seizures during preterm labor. Maternal diagnosis was initially made by placental pathology, and later confirmed by isolation of Mycobacterium tuberculosis in urine, gastric aspirates and sputum. Full screening was performed on the newborn infant, and both mother and infant were successfully treated for tuberculosis with a four drug regimen.

Conclusion

Pregnancy can exacerbate latent tuberculosis and women originating from endemic areas are especially susceptible. The best way to prevent congenital tuberculosis is to have a high index of suspicion and identify and treat tuberculosis in pregnant women.
Literature
1.
2.
3.
Bates M, Ahmed Y, Kapata N, Maeurer M, Mwaba P, Zumla A. Perspectives on tuberculosis in pregnancy. Int J Infect Dis. 2015;32:124–7.CrossRefPubMed
4.
Pillay T, Sturm AW, Khan M, Adhikari M, Moodley J, Connolly C, Moodley D, Padayatchi N, Ramjee A, Coovadia HM, et al. Vertical transmission of mycobacterium tuberculosis in KwaZulu natal: impact of HIV-1 co-infection. Int J Tuberculosis Lung Dis. 2004;8(1):59–69.
5.
Kitai I, Morris S, Kordy F, Lam R. Diagnosis and management of pediatric tuberculosis in Canada. CMAJ. 2017;9(189):E11–16.
6.
Skevaki CL, Kafetzis DA. Tuberculosis in neonates and infants: epidemiology, pathogenesis, clinical manifestations, diagnosis, and management issues. Paediatr Drugs. 2005;7(4):219–34.CrossRefPubMed
7.
Schaaf HS, Collins A, Bekker A, Davies PD. Tuberculosis at extremes of age. Respirology. 2010;15(5):747–63.CrossRefPubMed
8.
Di Comite A, Esposito S, Villani A, Stronati M, Grp IPTS. How to manage neonatal tuberculosis. J Perinatol. 2016;36(2):80–5.CrossRefPubMed
9.
Smith KC. Congenital tuberculosis: a rare manifestation of a common infection. Curr Opin Infect Dis. 2002;15(3):269–74.CrossRefPubMed
10.
Cantwell MF, Shehab ZM, Costello AM, Sands L, Green WF, Ewing Jr EP, Valway SE, Onorato IM. Brief report: congenital tuberculosis. N Engl J Med. 1994;330(15):1051–4.CrossRefPubMed
11.
Peng WS, Yang J, Liu EM. Analysis of 170 cases of congenital TB reported in the literature between 1946 and 2009. Pediatr Pulmonol. 2011;46(12):1215–24.CrossRefPubMed
12.
Tripathy SN, Tripathy SN. Infertility and pregnancy outcome in female genital tuberculosis. Int J Gynaecol Obstet. 2002;76(2):159–63.CrossRefPubMed
13.
Flibotte JJ, Lee GE, Buser GL, Feja KN, Kreiswirth BN, McSherry GD, Nolan SM, Tolan Jr RW, Zhang H. Infertility, in vitro fertilization and congenital tuberculosis. J Perinatol. 2013;33(7):565–8.CrossRefPubMed
14.
15.
Stuart RL, Lewis A, Ramsden CA, Doherty RR. Congenital tuberculosis after in-vitro fertilisation. Med J Aust. 2009;191(1):41–2.PubMed
16.
Doudier B, Mosnier E, Rovery C, Uters M, D'Ercole C, Brouqui P. Congenital tuberculosis after in vitro fertilization. Pediatr Infect Dis J. 2008;27(3):277–8.CrossRefPubMed
17.
Metadata
Title
Congenital tuberculosis in an extremely preterm infant conceived after in vitro fertilization: case report
Authors
Veronica Samedi
Stephen K. Field
Essa Al Awad
Gregory Ratcliffe
Kamran Yusuf
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2017
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-017-1256-1

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