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BMC Neurology

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Open Access 01-12-2018 | Case report

Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report

Authors: Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki

Published in: BMC Neurology | Issue 1/2018

Abstract

Background

Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge.

Case presentation

A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure. Brain computed tomography showed symmetric calcifications in the bilateral basal ganglia, thalamus, cerebellar dentate nuclei, which were consistent with IBGC. Diffusion-weighted brain magnetic resonance imaging showed multiple small infarctions in the bilateral cerebral subcortical area. In the search for the cause of cerebral infarction, SPECT with acetazolamide challenge revealed heterogeneous impairment of cerebrovascular reactivity in the whole brain, despite the absence of evidence for steno-occlusive changes in proximal arteries.

Conclusion

Cerebrovascular insufficiency due to the lack of elasticity caused by microvascular calcification might have been one of the pathophysiological features of IBGC in this case. Thus, vascular calcification may cause cerebrovascular disturbance and could lead to ischemic stroke in patients with IBGC.

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Title: Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report
Authors: Takuma Nishimoto
Fumiaki Oka
Hideyuki Ishihara
Mizuya Shinoyama
Michiyasu Suzuki
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2018
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-018-1048-x

ACC 2024 Congress

Springer Medicine

Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report

Abstract

Background

Case presentation

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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