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Open Access 01-12-2017 | Case report

MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome

Authors: Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl, Sergio Ferrari

Published in: BMC Neurology | Issue 1/2017

Abstract

Background

The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis.

Case presentation

A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia. Brain magnetic resonance imaging noted a widespread involvement of the white matter associated with slight cortical and subcortical damage in absence of contrast enhancement. An extensive infectious screening resulted negative while autoimmune analysis revealed the presence of MOG-Abs, detected with live cell-based assay. After treatment with intravenous immunoglobulins a marked and prompt clinical and radiological improvement was observed.

Conclusions

To date, several areas of uncertainty still remain regarding clinical features and prognosis of subjects with MOG-Abs. The description of atypical cases is crucial, since recognition of this condition leads to prompt treatment and better prognosis, as in the case here reported.

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Title: MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome
Authors: Sara Mariotto
Salvatore Monaco
Patrick Peschl
Ilaria Coledan
Romualdo Mazzi
Romana Höftberger
Markus Reindl
Sergio Ferrari
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2017
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-017-0971-6

At a glance: The STEP trials

Springer Medicine

MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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