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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Research article

Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features

Authors: Simone B. Schmidt, Jens D. Rollnik

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

Critical illness polyneuropathy (CIP) is a complex disease affecting 30–70% of critically ill patients.

Methods

Clinical (Barthel index, length of stay (LOS), morbidity, duration of mechanical ventilation, routine lab results) and neurophysiological (neurography) data of 191 patients admitted to neurological early rehabilitation and diagnosed with CIP have been analyzed retrospectively.

Results

CIP diagnosis was correct in 159 cases (83%). In this study, systemic inflammation, sepsis, systemic inflammatory response syndrome (SIRS), multiple organic failure (MOF), chronic renal failure, liver dysfunction, mechanical ventilation, diabetes, dyslipidemia and impaired ion homeostasis (hypocalcaemia, hypokalemia) were associated with CIP. Neurography, in particular of the peroneal, sural, tibial and median nerves, helped to identify CIP patients. Compound muscle action potential amplitude (r = −0.324, p < 0.05), as well as sensory (r = −0.389, p < 0.05) and motor conduction velocity (r = −0.347, p < 0.05) of the median nerve correlated with LOS in neurological early rehabilitation but not with outcome measures.

Conclusions

In most cases, diagnosis of CIP among neurological early rehabilitation patients seems to be correct. Neurography may help to verify the diagnosis and to learn more about CIP pathophysiology, but it does not allow outcome prediction. Further studies on CIP are strongly encouraged.
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Metadata
Title
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features
Authors
Simone B. Schmidt
Jens D. Rollnik
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0775-0

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