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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Research article

Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study

Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo, Zhen Hong, the Shanghai Aging Study (SAS)

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association between olfactory identification (OI) and cognitive function among community-dwelling elderly in China.

Methods

OI of each participant was measured by the 12-item identification tests from Sniffin’ Sticks Screening test (SSST-12). Participants with mild cognitive impairment (MCI) were diagnosed by Petersen criteria. We used the logistic regression analysis to explore the association between OI scores and cognitive function by adjusting potential confounders.

Results

Among 1782 non-demented participants, 345 (19.4 %) participants were diagnosed as MCI. The mean OI score for participants with MCI [7.1 (SD 2.3)] was significantly lower than that for those with normal cognition [8.2 (SD 2.0), P < 0.0001]. After adjusted for age, gender, education, lifestyles, medical history, Apolipoprotein E genotype, lower OI score was found to be an independent influence factor related to MCI (OR 1.19, 95 % CI 1.11–1.27).

Conclusions

Our study suggests that poor OI may be associated with MCI in elderly population. Further prospective studies may confirm the OI as a reliable and early marker predicting the decline of cognitive function.
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Metadata
Title
Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study
Authors
Xiaoniu Liang
Ding Ding
Qianhua Zhao
Qihao Guo
Jianfeng Luo
Zhen Hong
the Shanghai Aging Study (SAS)
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0725-x

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