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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Research article

Prevalence of stroke in children admitted with sickle cell anaemia to Mulago Hospital

Authors: Deogratias Munube, Elly Katabira, Grace Ndeezi, Moses Joloba, Samden Lhatoo, Martha Sajatovic, James K. Tumwine

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

Stroke is a major complication of sickle cell anaemia (SCA). It occurs commonly in childhood with about 10 % of children with sickle cell anaemia getting affected by this complication. In Uganda, there is paucity of data on the prevalence of stroke in children admitted in a tertiary institution. We determined the prevalence of stroke amongst children with SCA admitted to Mulago National Referral Hospital in Uganda and described the ir co-morbidities.

Methods

We conducted a retrospective record review of children with SCA admitted from August 2012 to August 2014 to the Paediatric Haematology Ward of Mulago Hospital in Kampala, Uganda. The target population was SCA children age 6 months-17 years of age. A descriptive analysis was used to summarize the demographic characteristics and clinical diagnosis.

Results

There were 2,176 children with SCA admitted who were included in this study. There were 147 children with stroke. Their mean age 6.1, (SD 3), with a male to female ratio was 1:1 (71 males and 76 females). The M: F ratio of non-stroke children was 1.1:1 (1084 males and 945 females) with a mean age of 5.2, (SD 3). The prevalence of stroke was 6.8 % (147 of 2176). Amongst the children with stroke, 72.1 % (106 of 147) had co-morbidities which included severe anaemia 21.7 % (23 of 106), bacteraemia and vaso-occlusive crisis 17 % (18 of 106), pneumonia 8.4 % (9 of 106) and malaria 6.6 % (7 of 106).

Conclusion

The prevalence of stroke in hospitalized Ugandan children with SCA was 6.8 %. Children with stroke were often admitted with other medical conditions such as severe anaemia, bacteraemia and vaso-occlusion.
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Literature
1.
*Husayn*i a-HbAi, Smith GR, Cahen C, Serjeant RB, University of Manchester.: A medieval administrative and fiscal treatise from the Yemen : the Rasulid Mulakhkha*s al-fi*tan by al-*Hasan b. *Al*i al-*Husayn*i : a facsimile edition of the Arabic text together with an introduction and annotated translation. Oxford: Oxford University Press on behalf of the University of Manchester; 2006.
2.
Powars D, Wilson B, Imbus C, Pegelow C, Allen J. The natural history of stroke in sickle cell disease. Am J Med. 1978;65(3):461–71.CrossRefPubMed
3.
Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, Wethers DL, Pegelow CH, Gill FM. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91(1):288–94.PubMed
4.
Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, Abboud M, Gallagher D, Kutlar A, Nichols FT, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339(1):5–11.CrossRefPubMed
5.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014;312(10):1033–48.CrossRefPubMed
6.
Fullerton HJ, Adams RJ, Zhao S, Johnston SC. Declining stroke rates in Californian children with sickle cell disease. Blood. 2004;104(2):336–9.CrossRefPubMed
7.
Ndeezi G, Kiyaga C, Hernandez AG, Munube D, Howard TA, Ssewanyana I, Nsungwa J, Kiguli S, Ndugwa CM, Ware RE, et al. Burden of sickle cell trait and disease in the Uganda Sickle Surveillance Study (US3): a cross-sectional study. Lancet Glob Health. 2016;4(3):e195–200.CrossRefPubMed
8.
World Health Organization. Pocket book of Hospital Care for Children. Firstth ed. Honk Kong: WHO Library Cataloguing-in-Publication; 2005.
9.
World Health Organization. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin Epidemiol 1988;41(2):105–14.
10.
Njamnshi AK, Mbong EN, Wonkam A, Ongolo-Zogo P, Djientcheu VD, Sunjoh FL, Wiysonge CS, Sztajzel R, Mbanya D, Blackett KN, et al. The epidemiology of stroke in sickle cell patients in Yaounde, Cameroon. J Neurol Sci. 2006;250(1–2):79–84.CrossRefPubMed
11.
Kehinde MO, Temiye EO, Danesi MA. Neurological complications of sickle cell anemia in Nigerian Africans--a case–control study. J Natl Med Assoc. 2008;100(4):394–9.CrossRefPubMed
12.
Balkaran B, Char G, Morris JS, Thomas PW, Serjeant BE, Serjeant GR. Stroke in a cohort of patients with homozygous sickle cell disease. J Pediatr. 1992;120(3):360–6.CrossRefPubMed
13.
George IO, Frank-Briggs AI. Stroke in Nigerain children with sickle cell anaemia. Journal of Public Health and Epidemiology. 2011;3(9):407–9.
14.
Serjeant GR, Ndugwa CM. Sickle cell disease in Uganda: a time for action. East Afr Med J. 2003;80(7):384–7.PubMed
15.
Amayo EO, Owade JN, Aluoch JR, Njeru EK. Neurological complications of sickle cell anaemia at KNH: a 5 year retrospective study. East Afr Med J. 1992;69(12):660–2.PubMed
16.
Kizito ME, Mworozi E, Ndugwa C, Serjeant GR. Bacteraemia in homozygous sickle cell disease in Africa: is pneumococcal prophylaxis justified? Arch Dis Child. 2007;92(1):21–3.CrossRefPubMed
17.
Adams RJ, McKie VC, Brambilla D, Carl E, Gallagher D, Nichols FT, Roach S, Abboud M, Berman B, Driscoll C, et al. Stroke prevention trial in sickle cell anemia. Control Clin Trials. 1998;19(1):110–29.CrossRefPubMed
Metadata
Title
Prevalence of stroke in children admitted with sickle cell anaemia to Mulago Hospital
Authors
Deogratias Munube
Elly Katabira
Grace Ndeezi
Moses Joloba
Samden Lhatoo
Martha Sajatovic
James K. Tumwine
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0704-2

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