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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Review

Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

Authors: Bjørn A. Nexø, Sara B. Jensen, Kari K. Nissen, Bettina Hansen, Magdalena J. Laska

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).

Results

The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.

Conclusion

We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.
Literature
1.
Nexø BA, Christensen T, Frederiksen J, Møller-Larsen A, Oturai AB, Villesen P, et al. The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. PLoS One. 2011;6:e16652.CrossRefPubMedPubMedCentral
2.
Nissen KK, Laska MJ, Hansen B, Terkelsen T, Villesen P, Bahrami S, et al. Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle. BMC Neurol. 2013;13:111.CrossRefPubMedPubMedCentral
3.
Nexø BA, Villesen P, Nissen KK, Lindegaard HM, Rossing P, Petersen T, Tarnow L, Hansen B, Jensen SB, Bahrami S, Lajer M, Schmidt KLM, Parving HH, Junker P, Laska MJ. Are human endogenous retroviruses triggers of autoimmune diseases? Unveiling associations of three diseases and viral loci. Immunol Res. 2016;64:55–63.CrossRefPubMedPubMedCentral
4.
Nexø BA, Hansen B, Nissen KK, Gundestrup L, Terkelsen T, Villesen P, et al. Restriction genes for retroviruses influence the risk of multiple sclerosis. PLoS One. 2013;8:e74063.CrossRefPubMedPubMedCentral
5.
Laska MJ, Brudek T, Nissen KK, Christensen T, Møller-Larsen A, Petersen T, et al. Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis. J Virol. 2012;86:3713–22.CrossRefPubMedPubMedCentral
6.
Hansen B, Oturai AB, Harbo HF, Celius EG, Nissen KK, Laska MJ, et al. Genetic association of multiple sclerosis with the endogenous retrovirus HERV-Fc1: Analysis of disease subtypes. PLoS ONE. 2011;6:e26438.CrossRefPubMedPubMedCentral
7.
de la Hera B, Varadé J, García-Montojo M, Alcina A, Fedetz M, Alloza I, et al. Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis. PLoS One. 2014;9:e90182.CrossRefPubMedPubMedCentral
8.
de la Hera B, Varadé J, García-Montojo M, Lamas JR, de la Encarnación A, Arroyo R, et al. Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis. PLoS One. 2013;8:e62090.CrossRefPubMedPubMedCentral
9.
Schmidt KLM, Vangsted AJ, Hansen B, Vogel UB, Hermansen NEU, Jensen SB, et al. Synergy of two human endogenous retroviruses in Multiple Myeloma. Leuk Res. 2015;39:1125.CrossRefPubMed
10.
Hayward WS, Neel BG, Astrin SM. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leucosis. Nature. 1981;290(5806):475–80.CrossRefPubMed
11.
Cuypers HT, Selten G, Quint W, Zijlstra M, Maandag ER, Boelens W, et al. Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984;37:141–50.CrossRefPubMed
12.
Johansen JN, Vartdal F, Desmarais C, Tutturen AE, de Souza GA, Lossius A, et al. Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome. Clin Immunol. 2015;160:211–25.CrossRefPubMed
13.
Jolicoeur P, Nicolaiew N, DesGroseillers L, Rassart E. Molecular cloning of infectious viral DNA from ecotropic neurotropic wild mouse retrovirus. J Virol. 1983;45:1159–63.PubMedPubMedCentral
14.
Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de Thé G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2(8452):407–10.CrossRefPubMed
15.
16.
Henzy JE, Johnson WE. Pushing the endogenous envelope. Phil Trans B. 2013;368:1626.CrossRef
17.
Nexø BA, Pedersen L, Sørensen HT, Koch-Henriksen N. Treatment of HIV and risk of multiple sclerosis. Epidemiology. 2013;24:331–2.CrossRefPubMed
18.
Gold J, Goldacre R, Maruszak H, Giovannoni G, Yeates D, Goldacre M. HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study. J Neurol Neurosurg Psychiatry. 2015;86(1):9–12.CrossRefPubMedPubMedCentral
19.
Chin JH. Multiple sclerosis and HIV-1 infection: case report of a HIV controller. J Neurovirol. 2015;21:464–7.CrossRefPubMed
20.
Maruszak H, Brew BJ, Giovannoni G, Gold J. Could antiretroviral drugs be effective in multiple sclerosis? A case report. Eur J Neurol. 2011;18:e110–1.CrossRefPubMed
21.
Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476:214–9.CrossRefPubMedPubMedCentral
22.
Garson JA, Tuke PW, Giraud P, Paranhos-Baccala G, Perron H. Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis. Lancet. 1998;351:33.CrossRefPubMed
Metadata
Title
Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
Authors
Bjørn A. Nexø
Sara B. Jensen
Kari K. Nissen
Bettina Hansen
Magdalena J. Laska
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0580-9

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