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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Research article

Variations in and predictors of the occurrence of depressive symptoms and mood symptoms in multiple sclerosis: a longitudinal two-year study

Authors: Sverker Johansson, Kristina Gottberg, Marie Kierkegaard, Charlotte Ytterberg

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

There is limited knowledge regarding how depressive symptoms and a cluster of specific mood symptoms in people with multiple sclerosis (MS) vary over time and how they are influenced by contributing factors. Therefore, the aims of this study were a) to describe variations over 2 years in the occurrence of depressive symptoms and mood symptoms in a sample of people with MS, and b) to investigate the predictive value of sex, age, coping capacity, work status, disease severity, disease course, fatigue, cognition, frequency of social/lifestyle activities, and perceived impact of MS on health, on the occurrence of depressive symptoms and mood symptoms.

Methods

Through using a protocol of measures of functioning and perceived impact of MS on health, comprising of the Beck Depression Inventory, 219 people with MS were assessed at 0, 12 and 24 months. Predictive values were explored with Generalised Estimating Equations.

Results

Proportions with depressive symptoms varied significantly (p < 0.001) from 21 to 30 % between the three time points. Proportions with mood symptoms varied significantly (p < 0.001) from 14 to 17 % between the three time points. Weak coping capacity and reduced frequency of social/lifestyle activities predicted the occurrence of depressive symptoms and mood symptoms, as did the psychological impact of MS on health in interaction with time. For people with MS of working age, not working predicted the occurrence of depressive symptoms and mood symptoms, as did the physical impact of MS on health on the occurrence of mood symptoms.

Conclusions

The occurrence of depressive symptoms and mood symptoms in people with MS vary over a 2-year time period; almost half have depressive symptoms at least once. Health care services should develop strategies aimed at identifying people with MS who are depressed or who develop depressive symptoms. Interventions for alleviating depressive symptoms should consider the individual’s coping capacity and perceived impact of MS on health, and facilitate their ability to maintain participation in valued everyday activities.
Literature
1.
McAlpine D, Compston A. McAlpine's multiple sclerosis. Philadelphia, Pa: Churchill Livingstone/Elsevier; 2006.
2.
Klauer T, Schneider W, Zettl UK. Coping with neuroimmunological diseases. J Neurology. 2007;254 Suppl 2:II107–11.
3.
Mikula P, Nagyova I, Krokavcova M, Vitkova M, Rosenberger J, Szilasiova J, et al. Coping and its importance for quality of life in patients with multiple sclerosis. Disabil Rehabil. 2014;36:732–6.CrossRefPubMed
4.
Lynch SG, Kroencke DC, Denney DR. The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope. Mult Scler. 2001;7:411–6.CrossRefPubMed
5.
Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry. 2002;159:1862–8.CrossRefPubMed
6.
Gottberg K, Einarsson U, Fredrikson S, von Koch L, Holmqvist LW. A population-based study of depressive symptoms in multiple sclerosis in Stockholm county: association with functioning and sense of coherence. J Neurol Neurosurg Psychiatry. 2007;78:60–5.CrossRefPubMedPubMedCentral
7.
Patten SB, Beck CA, Williams JV, Barbui C, Metz LM. Major depression in multiple sclerosis: a population-based perspective. Neurology. 2003;61:1524–7.CrossRefPubMed
8.
9.
Chruzander C, Ytterberg C, Gottberg K, Einarsson U, Widen Holmqvist L, Johansson S. A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: changes in health-related quality of life and the value of different factors in predicting health-related quality of life. J Neurol Sci. 2014;339:57–63.CrossRefPubMed
10.
Koch MW, Patten S, Berzins S, Zhornitsky S, Greenfield J, Wall W, et al. Depression in multiple sclerosis: a long-term longitudinal study. Mult Scler. 2015;21:76–82.CrossRefPubMed
11.
Wood B, van der Mei IA, Ponsonby AL, Pittas F, Quinn S, Dwyer T, et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Mult Scler. 2013;19:217–24.CrossRefPubMed
12.
Huber SJ, Rammohan KW, Bornstein RA, Christy JA. Depressive symptoms are not influenced by severity of multiple sclerosis. Neuropsych Neuropsychol Behav Neurol. 1993;6:177–80.
13.
Ytterberg C, Johansson S, Andersson M, Widen Holmqvist L, von Koch L. Variations in functioning and disability in multiple sclerosis. A two-year prospective study. J Neurol. 2008;255:967–73.CrossRefPubMed
14.
Bakshi R, Shaikh ZA, Miletich RS, Czarnecki D, Dmochowski J, Henschel K, et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler. 2000;6:181–5.CrossRefPubMed
15.
Sundgren M, Maurex L, Wahlin A, Piehl F, Brismar T. Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis. Arch Clin Neuropsychol. 2013;28:144–55.CrossRefPubMed
16.
Ben Ari Shevil E, Johansson S, Ytterberg C, Bergstrom J, von Koch L. How are cognitive impairment, fatigue and signs of depression related to participation in daily life among persons with multiple sclerosis? Disabil Rehabil. 2014;36:2012–8.CrossRefPubMed
17.
Stuifbergen AK, Rogers S. Health promotion: an essential component of rehabilitation for persons with chronic disabling conditions. Adv Nurs Sci. 1997;19:1–20.CrossRef
18.
Goldman CG. The Goldman Consensus statement on depression in multiple sclerosis. Mult Scler. 2005;11:328–37.CrossRef
19.
Amato MP, Ponziani G, Rossi F, Liedl CL, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler. 2001;7:340–4.CrossRefPubMed
20.
Benedict RH, Wahlig E, Bakshi R, Fishman I, Munschauer F, Zivadinov R, et al. Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. J Neurol Sci. 2005;231:29–34.CrossRefPubMed
21.
Patten SB, Metz LM, Reimer MA. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Mult Scler. 2000;6:115–20.CrossRefPubMed
22.
Chruzander C, Johansson S, Gottberg K, Einarsson U, Fredrikson S, Holmqvist LW, et al. A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: Changes in disability and the value of different factors in predicting disability and mortality. J Neurol Sci. 2013;332:121–7.CrossRefPubMed
23.
24.
Koch MW, Glazenborg A, Uyttenboogaart M, Mostert J, De Keyser J. Pharmacologic treatment of depression in multiple sclerosis. Cochrane Database Syst Rev. 2011;(2):CD007295.
25.
Mohr DC, Carmody T, Erickson L, Jin L, Leader J. Telephone-administered cognitive behavioral therapy for veterans served by community-based outpatient clinics. J Consult Clin Psychol. 2011;79:261–5.CrossRefPubMed
26.
Thomas PW, Thomas S, Hillier C, Galvin K, Baker R. Psychological interventions for multiple sclerosis. Cochrane Database Syst Rev. 2006;(1):CD004431.
27.
Johansson S, Ytterberg C, Claesson IM, Lindberg J, Hillert J, Andersson M, et al. High concurrent presence of disability in multiple sclerosis. Associations with perceived health. J Neurol. 2007;254:767–73.CrossRefPubMed
28.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71.CrossRefPubMed
29.
Antonovsky A. The structure and properties of the sense of coherence scale. Soc Sci Med. 1993;36:725–33.CrossRefPubMed
30.
Larsson G, Kallenberg K. Sense of coherence, socioeconomic conditions and health. Eur J Publ Health. 1996;6:175–80.CrossRef
31.
Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33:1444–52.CrossRefPubMed
32.
Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121–3.CrossRefPubMed
33.
Smith A. Symbol Digit Modalities Test (SDMT). In: Lezak MD, editor. Neuropsychological assessment. New York: Oxford University Press; 1995. p. 379–81.
34.
Turnbull JC, Kersten P, Habib M, McLellan L, Mullee MA, George S. Validation of the Frenchay Activities Index in a general population aged 16 years and older. Arch Phys Med Rehabil. 2000;81:1034–8.CrossRefPubMed
35.
Wade DT, Legh-Smith J, Langton HR. Social activities after stroke: measurement and natural history using the Frenchay Activities Index. Int Rehabil Med. 1985;7:176–81.CrossRefPubMed
36.
Hobart J, Lamping D, Fitzpatrick R, Riazi A, Thompson A. The Multiple Sclerosis Impact Scale (MSIS-29): a new patient-based outcome measure. Brain. 2001;124:962–73.CrossRefPubMed
37.
Johansson S, Ytterberg C, Hillert J, Widen Holmqvist L, von Koch L. A longitudinal study of variations in and predictors of fatigue in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:454–7.CrossRefPubMed
38.
Nilsson KW, Leppert J, Simonsson B, Starrin B. Sense of coherence and psychological well-being: improvement with age. J Epidemiol Community Health. 2010;64:347–52.CrossRefPubMed
39.
Johnson KL, Yorkston KM, Klasner ER, Kuehn CM, Johnson E, Amtmann D. The cost and benefits of employment: a qualitative study of experiences of persons with multiple sclerosis. Arch Phys Med Rehabil. 2004;85:201–9.CrossRefPubMed
40.
Khan F, Ng L, Turner-Stokes L. Effectiveness of vocational rehabilitation intervention on the return to work and employment of persons with multiple sclerosis. Cochrane Database Syst Rev. 2009;(1):CD007256.
Metadata
Title
Variations in and predictors of the occurrence of depressive symptoms and mood symptoms in multiple sclerosis: a longitudinal two-year study
Authors
Sverker Johansson
Kristina Gottberg
Marie Kierkegaard
Charlotte Ytterberg
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0551-1

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